"I was delighted to take part in a clinical trial as it has the potential to really help others in the future.”
A trial looking at a type of radiotherapy called PIT in people who have had tests for a type of lung cancer called mesothelioma (PIT)
Please note - this trial is no longer recruiting patients. We hope to add results when they are available.
This trial is looking at whether treating the wound from your mesothelioma tests with radiotherapy helps to prevent or delay small cancer growths (nodules) developing in that area.
Mesothelioma is a rare form of cancer that can grow in the protective lining that covers many of the body's internal organs. It is diagnosed most often in the tissue that covers the lungs and lines the internal
One of the tests for mesothelioma of the lung includes putting a thin tube into the chest wall. The doctor can then look inside and remove samples (biopsies) or fluid. These procedures can cause cancerous skin lumps called nodules to develop along the passage (tract) where the tube was put in. You may have
Although many hospitals already give PIT, we still don’t know if the treatment works. The aim of this trial is to see whether PIT can prevent or delay nodules developing. If it does, doctors can then offer it to everyone as part of their treatment. But if it doesn’t, people will not have to go through treatment that will not help them.
Who can enter
You may be able to enter this trial if
- You have mesothelioma that started in the covering of your lung
- You cannot have surgery to remove your mesothelioma
- You are well enough to be up and about for at least half the day (performance status 0, 1 or 2)
- You have either had fluid removed from your chest and tested for mesothelioma cells or had a sample of lung tissue removed through a cut in your
chest wallusing a thoracoscopyunder local anaesthetic, a video assisted thoracoscopy, or surgery
- You are able to start radiotherapy within 6 weeks of one of these procedures, and the scar from the test can be clearly seen on your chest wall
- Your radiotherapy specialist is happy that the dose you would need is within safe levels for you
- You are willing to use reliable contraception if there is a chance that you or your partner could become pregnant
- You are at least 18 years old
You cannot enter this trial if you
- Have a tube running from your chest to drain fluid (a chest drain)
- Have had a type of surgery called an open thoracotomy
- Have already had radiotherapy to the area the trial team want to treat
- Have had chemotherapy for mesothelioma
- Have any condition that could affect the results of the trial - you can check this with your doctor
- Are pregnant or breastfeeding
This trial will recruit about 400 people. It is randomised. The people taking part will be put into one of 2 groups by a computer. Neither you nor your doctor will be able to decide which group you are in.
If you are in group 1, you will not have PIT radiotherapy.
If you are in group 2, you will have PIT radiotherapy. You have treatment once a day for 3 days. Each session will take about 15 minutes.
Taking part in this trial won’t stop you from having any other treatment you may need for your mesothelioma. If you are in group 2, you will start any other treatment a week after your PIT radiotherapy has finished.
The trial team will give you a diary to fill out regularly at home. A member of the trial team will ring you at home once a month when you are not due to come to the hospital. They will continue to phone you either until a nodule develops under your skin, or you have been in the trial for 2 years. If you do find a nodule, the team will arrange for you to come to hospital within a week for a specialist to look at it.
Before you join the trial you see the doctor and have a physical examination. You then visit the hospital after
- 6 weeks
- 3 months
- 6 months
- 12 months
You have a physical examination at these appointments, and the team will
- Ask how you are getting on day to day
- Check for any skin reaction (if you had PIT radiotherapy)
- Ask if you have any pain
- Ask about any other treatment you are having for mesothelioma
How to join a clinical trial
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Professor Corinne Faivre-Finn
Dr Neil Bayman
Experimental Cancer Medicine Centre (ECMC)
NIHR Clinical Research Network: Cancer
NIHR Research for Patient Benefit (RfPB) Programme
The Christie NHS Foundation Trust