A trial looking at treatment for Ewing's sarcoma family of tumours (Euro Ewing 2012)

Cancer type:

Children's cancers
Ewing's sarcoma




Phase 3

This trial is looking at treatment for the Ewing’s sarcoma family of tumours. Cancer Research UK supports this study.

This study is for both adults and children. We use the term ‘you’ in this summary, but of course if you are a parent, we are referring to your child.


More about this trial

Treatment for the Ewing’s sarcoma family of tumours  Open a glossary itemusually includes chemotherapy. You may have treatment that includes the drugs vincristineifosfamidedoxorubicin and etoposide. Doctors call this VIDE. Or you may have vincristine, doxorubicin, cyclophosphamide, ifosfamide and etoposide, which is called VDC/IE.

This is to shrink the cancer before having surgery. If the doctor can’t completely remove your sarcoma with surgery, you may also have radiotherapy.

As with any cancer there is a risk that your sarcoma may come back or start to grow again. To try and reduce this risk doctors give more chemotherapy after surgery.

In this trial the researchers want to compare VIDE with VDC/IE to find out which is best to use before surgery. They also want to compare different types of chemotherapy after surgery to find out which is the best.

Who can enter

You may be able to join this trial if all of the following apply.

You cannot join this trial if any of these apply.

  • You have already had treatment for your cancer, apart from surgery
  • You have another type of cancer
  • You are not able to have any of the drugs used in this trial
  • You are pregnant or breastfeeding

Trial design

This is an international phase 3 trial. The researchers need about 600 people to join the trial.

There are 2 parts in this trial. After the 1st part of the trial, if you don’t want to continue with the 2nd part you don’t have to.

Before starting treatment, you have a central line put in. This is a plastic tube that goes into a large vein near your heart. You have your drugs through it and blood samples can be taken from it.

The first part of this trial is randomised

Euro Ewing 2012 trial diagram

After chemotherapy the trial team will assess how your sarcoma has responded. You then have surgery, radiotherapy or both.

They will then look at the risk of your sarcoma coming back or starting to grow again and put you into groups. If your sarcoma was small to start with and responded well to chemotherapy, you will be in the standard risk group. If your sarcoma was large and didn’t respond as well to chemotherapy, you will be in the high risk group.

If your sarcoma has already spread to your lungs, you will be in another group.

The second part of this trial is also randomised. You will be randomised to have chemotherapy with zoledronic acid or without zoledronic acid.

Those who had VIDE in the first part of the trial will have one of the following.

If you are in the standard risk group, you have either

For your 1st treatment only you will have ifosfamide instead of cyclophosphamide.

If you are in the high risk group, or your sarcoma has spread to the lungs, you have either

  • Vincristine, actinomycin D and ifosfamide and zoledronic acid
  • Vincristine, actinomycin D and ifosfamide

Those who had VDC/IE in the first part of the trial will have one of the following

  • Ifosfamide, etoposide, vincristine, cyclophosphamide and zoledronic acid
  • Ifosfamide, etoposide, vincristine and cyclophosphamide

If you agree to take part in this trial, the researchers will ask for a sample of your cancer, bone marrow Open a glossary item and blood from when you were diagnosed and during your treatment. If you don’t want to give the bone marrow and blood samples during treatment you don’t have to. You can still take part in the trial.

Hospital visits

You see the doctor to have some tests before taking part in this trial. These tests include

You have a physical examination and blood tests after each treatment of chemotherapy. You have the scan and heart scan as needed. You have another bone marrow test done if your sacoma had alredy spread to the bone marrow when you joined the study. 

At the end of treatment you have a MRI scan and another 6 months later if needed.

After treatment your doctor will tell you how often they need to see you.

Side effects

The most common side effects of the drugs used in this trial are

Your doctor will talk to you about the possible side effects before you agree to take part in the trial.

We have specific information on the side effects of vincristine, etoposide, actinomycin D, ifosfamide, doxorubicin, cyclophosphamide, and zoledronic acid.


Newcastle upon Tyne

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Dr Bernadette Brennan

Supported by

Cancer Research UK
Experimental Cancer Medicine Centre (ECMC)
NIHR Clinical Research Network: Cancer
University of Birmingham

Other information

This is Cancer Research UK number CRUK/11/050.

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:


Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Charlie took part in a trial to try new treatments

A picture of Charlie

“I think it’s really important that people keep signing up to these type of trials to push research forward.”

Last reviewed:

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