Around 1 in 5 people diagnosed with cancer in the UK take part in a clinical trial.
A trial looking at surgery for ovarian cancer that has come back (DESKTOP 3)
Please note - this trial is no longer recruiting patients. We hope to add results when they are available.
This trial is looking at chemotherapy and surgery for women with ovarian cancer that has come back (relapsed). This trial is supported by Cancer Research UK.
Doctors can treat ovarian cancer with surgery alone or surgery and chemotherapy. But sometimes the cancer starts to grow again. When this happens it can be more difficult to treat. Doctors usually treat ovarian cancer that has started to grow again with chemotherapy alone.
In this trial doctors want to find out if surgery and chemotherapy is better than chemotherapy alone for ovarian cancer that has come back.
The aims of this study are to find out
- If surgery and chemotherapy is better than chemotherapy alone to treat ovarian cancer that has come back
- The side effects
Who can enter
You may be able to enter this trial if you
- Have ovarian cancer known as epithelial ovarian cancer, fallopian tube cancer or primary peritoneal cancer that has come back more than 6 months after treatment with
platinum chemotherapyor have had early stage ovarian cancer that was treated with surgery alone, and the cancer has come back
- Are well enough to have surgery to remove your cancer
- Have ovarian cancer that can be removed with surgery
- Are at least 18 years old
You cannot enter this trial if you
- Have a type of ovarian cancer known as non epithelial or borderline
- Have had tummy (abdominal) surgery for any other cancer
- Have a swollen tummy of fluid known as
- Have had ovarian cancer that did not go away after treatment with
- Have any medical condition that could make it unsafe for you to take part in this trial
- Are taking any medication that could affect blood clotting, for example bevacizumab or warfarin
This is a randomised trial. The women taking part are put into 2 treatment groups by a computer. Neither you nor your doctor will be able to decide which group you are in.
Women in one group have surgery to remove the cancer followed by chemotherapy. Women in the other group have chemotherapy alone.
Your doctor will decide which chemotherapy drugs are best for you and explain about the side effects.
The trial team will ask you to fill out a questionnaire before you start treatment and then 6 and 12 months later. The questionnaire will ask about side effects and how you have been feeling. This is called a quality of life study.
You see the doctors and have some tests before you start treatment. The tests include
You see your cancer doctor and have tests often while you have treatment. These visits are not part of the trial and your doctor will explain them to you.
As part of the trial everyone has an interview with the researchers 60 days after starting chemotherapy.
They then have a blood test and physical examination
- Every 3 months for 2 years
- Every 6 months for 3 years
- Once a year after that
The most common side effects of surgery for ovarian cancer are
- Problems with wound healing
- Problems with digestion
- Blood clots (DVT)
How to join a clinical trial
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Professor David Luesley
Cancer Research UK
Cancer Research UK Clinical Trials Unit Birmingham
Experimental Cancer Medicine Centre (ECMC)
NIHR Clinical Research Network: Cancer
This is Cancer Research UK trial number CRUK/11/022