A trial looking at everolimus for neuroendocrine tumours (RADIANT 4)

Cancer type:

Neuroendocrine tumour (NET)

Status:

Results

Phase:

Phase 3

This trial looked at everolimus (Afinitor) to treat neuroendocrine tumours (NETs) of the digestive system or lungs.

More about this trial

Neuroendocrine tumours (NETs) are a rare group of cancers that develop in the neuroendocrine system. Some make extra hormones and cause symptoms, and others don’t.

This trial was for people who had a NET of the digestive system Open a glossary item or lungs that didn’t make extra hormones. These are non functioning NETs.

Everolimus is a type of biological therapy called a cancer growth blocker. We know from research that everolimus helps treat NETs that affect other parts of the body.

The aim of this trial was to find if everolimus could help people with non functioning NETs of the digestive system or lungs.

Summary of results

The team found that everolimus did help people with non functioning NETs of the digestive system or lungs.

This was a phase 3 trial. It was a double blinded randomised trial. Neither the people who took part or their doctor could choose which group they were in. And they also didn’t know which group they were in.

302 people took part.

  • 205 had everolimus
  • 97 had a dummy drug (placebo Open a glossary item)

Diagram showing trial results randomisation

The researchers looked at the average length of time it took for the NET to start growing again. They found it was:

  • 11 months for those who had everolimus
  • just under 4 months for those who had the dummy drug

The most severe side effects of everolimus were:

  • sore mouth
  • diarrhoea
  • infections
  • a drop in red blood cells
  • an increased level of sugar in the blood

The trial team concluded that everolimus significantly improved the length of time it took before the NET started to grow again.

The researchers are still following up these people to find out if everolimus increased the length of time people live after treatment. When these results become available we will update this summary. 

We have based this summary on information from the research team. The information they sent us has been reviewed by independent specialists (peer reviewed Open a glossary item) and published in a medical journal. The figures we quote above were provided by the trial team who did the research. We have not analysed the data ourselves.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Dr Juan Valle

Supported by

Experimental Cancer Medicine Centre (ECMC)
NIHR Clinical Research Network: Cancer
Novartis

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:

9478

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Wendy took part in a new trial studying the possible side effect of hearing loss

A picture of Wendy

"I was delighted to take part in a clinical trial as it has the potential to really help others in the future.”

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