A trial looking at weekly chemotherapy for ovarian cancer (ICON 8)

Please note - this trial is no longer recruiting patients. We hope to add results when they are available.

Cancer type:

Ovarian cancer




Phase 3

This trial is comparing weekly chemotherapy with 3 weekly chemotherapy for ovarian cancer, fallopian tube cancer or primary peritoneal cancer. These cancers are all treated in the same way, so when we use the term ovarian cancer in this summary, we are referring to all 3. This trial is supported by Cancer Research UK.

Doctors usually treat ovarian cancer with surgery and chemotherapy. They commonly use the chemotherapy drugs carboplatin and paclitaxel (Taxol).

You usually have chemotherapy once every 3 weeks. Each 3 week period is called a cycle of treatment. You usually have 6 cycles all together. This is known as the standard treatment Open a glossary item.

In this trial, researchers want to find out if having a lower dose of chemotherapy once a week is better than the standard treatment. Some women taking part will have standard treatment, some will have carboplatin once every 3 weeks and paclitaxel once a week, some will have both drugs once a week.

Some women taking part have surgery first, followed by 6 cycles of chemotherapy. Some women have 3 cycles of chemotherapy first, then they have surgery followed by 3 more cycles of chemotherapy.

The aims of the trial are to see

  • If weekly chemotherapy is better than 3 weekly chemotherapy for women with ovarian cancer
  • Whether it causes more or fewer side effects

Who can enter

You can enter this trial if you

You cannot enter this trial if you

Trial design

This is a phase 3 trial. It will recruit about 1,500 women. It is a randomised trial. The people taking part are put into treatment groups by a computer. Neither you nor your doctor will be able to decide which group you are in.

  • Women in group 1 have standard treatment which is carboplatin and paclitaxel once every 3 weeks
  • Women in group 2 have carboplatin once every 3 weeks and a lower dose of paclitaxel once a week
  • Women in group 3 have lower doses of both carboplatin and paclitaxel once a week

You have carboplatin and paclitaxel through a drip into a vein. The exact length of time it takes to have the drugs depends on which treatment group you are in.

You may have surgery followed by 6 cycles of chemotherapy. Or you may have 3 cycles of chemotherapy followed by surgery, then 3 more cycles of chemotherapy. But everybody will have chemotherapy for a total of 18 weeks.

If you are in group 2 or group 3 and have your surgery after 3 cycles of treatment, you will not have any chemotherapy in the 3rd week of the 3rd treatment cycle. This gives you a bit longer to recover before your surgery which you have a couple of weeks later.

Everybody will be asked to fill out a questionnaire before starting treatment, at the beginning of each cycle of chemotherapy and at follow up appointments after you finish treatment. The questionnaire will ask about any side effects you have had and about how you have been feeling. This is called a quality of life study.

The trial team will ask your permission to take some blood samples during the trial, and to get a sample of tissue removed when you have (or had) surgery. Researchers will use these samples to look for substances called biomarkers. These may help in the future to work out which women would benefit most from having weekly chemotherapy.

They also want to look for biomarkers that could show that a cancer is starting to grow again before it can be seen on scans. And they want to look at how genes might affect ovarian cancer and how people respond to treatment. You don’t have to give these extra samples for research if you don’t want to. You can still take part in the trial.

Hospital visits

You will see the trial doctors and have some tests before you start chemotherapy. The tests include

Women in group 1 go to hospital once every 3 weeks to have treatment. Women in the other 2 groups go every week.

You have blood tests before each chemotherapy treatment, so women in groups 2 and 3 will have 12 extra blood tests.

You have a scan after 6 cycles of treatment and the first 186 women to join the trial will be asked to have an extra scan 9 months after they were randomised to their treatment group.

After you finish treatment, you will see the trial team

  • Every 6 weeks until 9 months after you joined the trial
  • Then every 3 months until you have been in the trial for 2 years
  • And every 6 months for 4 years after that

Side effects

The possible side effects of carboplatin and paclitaxel include

It is possible that having chemotherapy each week may make side effects more likely or more severe. But the trial doctors don’t expect it to cause any different side effects.

Some women have an allergic reaction to paclitaxel and occasionally to carboplatin. You have drugs called steroids and antihistamines before each treatment to reduce the risk of a reaction.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Dr Andrew Clamp

Supported by

Cancer Research UK
Experimental Cancer Medicine Centre (ECMC)
Medical Research Council (MRC)
NIHR Clinical Research Network: Cancer

Other information

This is Cancer Research UK trial number CRUK/10/030. 

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:

Oracle 6183

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Over 60,000 cancer patients enrolled on clinical trials in the UK last year.

Last reviewed:

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