A trial looking at a new way to help diagnose lung cancer

Please note - this trial is no longer recruiting patients. We hope to add results when they are available.

Cancer type:

Lung cancer





This trial is looking at a computer model called ‘fuzzy logic’ to see if it can help diagnose lung cancer.

There are different tests to diagnose lung cancer, including

  • Looking for cancer cells in a sample of sputum or lung tissue (histology)
  • Scans such as a chest X-ray or CT scan
  • Testing blood samples

But some of these tests are invasive and doctors are keen to find other ways of diagnosing lung cancer. One way is to look more closely at blood samples.

Tumour markers are substances produced by cancer cells and found in the blood. Doctors are hoping to put lots of information about different tumour markers into the ‘fuzzy logic’ computer programme. This should help them to see more clearly any patterns linking certain markers to certain lung cancers. This may help them to diagnose lung cancer more accurately in future.

If you are suitable for this trial your doctor will ask you if you would like to take part. You will not have any direct benefit from taking part in this trial, and it is unlikely to change your treatment plan in any way. But the results of the trial will be used to help people with lung cancer in the future.

Who can enter

You can enter this trial if

  • You have non cancerous (benign) lung disease
  • You are having an examination of your airways (bronchoscopy) to find out if you have lung cancer or benign lung disease
  • You have recently been diagnosed with lung cancer

You cannot enter this trial if you have had any other type of cancer before.

Trial design

Doctors hope to recruit 1,000 people into this trial. There will be 6 groups.

If you have non cancerous (benign) lung disease you will be in group 1. If you have been diagnosed with lung cancer, you will be in one of the other 5 groups, depending on

  • Which type of lung cancer you have
  • What stage it is
  • How well you are (your ‘performance status’)

Everyone taking part in the trial will give 1 or 2 blood samples (depending on when you last had a blood test).

Doctors will put the information from each trial blood sample into the computer. The more results there are in the computer from each group, the more accurate the diagnosis should be.

Hospital visits

All groups will have up to 2 blood tests in total. One is a routine test, and the other is for the trial.

If you haven’t had a routine test recently, your doctor will tell you when to have this (usually in the month before the trial sample is taken). If you have had a routine blood test recently, you may only need to have a trial sample taken. For the trial sample

  • If you are having a bronchoscopy, you will have the trial blood test when you go back to hospital for the result
  • If you are not waiting for a bronchoscopy your doctor will let you know the best time to have your blood test

Side effects

As the trial simply involves a blood test, doctors do not expect there to be any side effects.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Dr P Lorigan

Supported by

Experimental Cancer Medicine Centre (ECMC)
MeDis Research Ltd

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:

Oracle 840

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Over 60,000 cancer patients enrolled on clinical trials in the UK last year.

Last reviewed:

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