A study to understand how women with ovarian cancer feel when having chemotherapy to control symptoms

Please note - this trial is no longer recruiting patients. We hope to add results when they are available.

Cancer type:

Ovarian cancer





This study is looking at changes in symptoms of ovarian cancer during and after a course of chemotherapy aimed at controlling symptoms.

If you have had chemotherapy to treat ovarian cancer, but it has come back or continued to grow, your doctor will offer you more chemotherapy to treat your symptoms and maintain or improve your quality of life Open a glossary item. This chemotherapy is called palliative Open a glossary item chemotherapy.

We know that chemotherapy may improve symptoms such as loss of appetite, tiredness and bowel problems. But researchers in this study are interested in how women feel during palliative chemotherapy for ovarian cancer, and whether they feel their symptoms improve while they are having treatment. They would also like to find out if there are any factors that might predict how well women are likely to do on palliative chemotherapy.

Women taking part will fill out questionnaires asking about quality of life before, during and after treatment, to see how symptoms may improve and change during this time. They hope that this information will in future help women and the health professionals caring for them make the best decisions when thinking about having chemotherapy to control symptoms of ovarian cancer.

Who can enter

You may be able to enter this study if you

  • Have cancer of the ovary, fallopian tube cancer or primary peritoneal cancer
  • Have had treatment but your cancer continued to grow while you were on the treatment or has come back within 6 months of finishing it
  • Are due to start a second or third course of chemotherapy in the next 2 weeks
  • Are able to complete questionnaires on your own
  • Are at least 18 years old

You cannot enter this study if you are in bed or chair all the time and need complete care (performance status 4).

Trial design

This study will recruit about 800 women internationally. 120 women will be taking part in the UK.

When you join the study, and every 6 to 8 weeks while you are on the study, your doctor will see you and will let the study team have information on any tests or investigations you have as part of your treatment. You will also fill out a booklet of questionnaires before, during and after your course of treatment. The questionnaires will ask you about

  • Your quality of life
  • Problems you have had
  • Symptoms
  • How you cope
  • The support you have outside of your medical care (social support)

These questionnaires are called quality of life questionnaires. They should take about 20 to 30 minutes to complete each time.

The research nurse will also collect information from your medical records about your condition and the care you have for your cancer. They will continue to collect this after your treatment finishes.

Hospital visits

You see the study team, fill out your questionnaires and may have further assessments

  • When you join the study
  • Before each cycle of treatment
  • Every 3 to 4 weeks after you finish treatment, for as long as your condition is stable

These appointments are planned to be at the same time as your routine hospital appointments and treatment as far as possible.

Side effects

You should not have any side effects as a result of taking part in this study.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Dr Anne Lanceley

Supported by

Experimental Cancer Medicine Centre (ECMC)
NIHR Clinical Research Network: Cancer
Target Ovarian Cancer
University College London (UCL)

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:

Oracle 9977

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Charlie took part in a trial to try new treatments

A picture of Charlie

“I think it’s really important that people keep signing up to these type of trials to push research forward.”

Last reviewed:

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