A study to understand more about the growth and treatment of a rare type of non Hodgkin lymphoma (IELSG 26)

Please note - this trial is no longer recruiting patients. We hope to add results when they are available.

Cancer type:

High grade lymphoma
Non-Hodgkin lymphoma




Phase 2/3

This study will look at tissue samples and PET scans to learn more about a type of non Hodgkin lymphoma called ‘primary mediastinal diffuse large B cell lymphoma’ (PMBL), and the best way to treat it. This trial is supported by Cancer Research UK.

Diffuse large B cell lymphoma (DLBCL) is a type of high grade non Hodgkin lymphoma. ’Mediastinal’ means it started in the glands (lymph nodes) in the centre of the chest (the ‘mediastinum’).

Doctors often treat PMBL with chemotherapy and a monoclonal antibody called rituximab. You could have one of several chemotherapy combinations. After this, you may also have radiotherapy to your chest. Doctors want to find the best treatment plan for PMBL. Researchers will study a sample of your lymphoma tissue. They will also study PET scans taken before and after chemotherapy. The aims of this study are to

  • Understand more about PMBL and the best way to treat it
  • See if PET scans will be useful in showing how well the treatment has worked

You will not have any direct benefit from taking part in this study, and it is unlikely to change your treatment plan in any way. But the results will be used to help people with cancer in the future.

Who can enter

You can enter this study if you

  • Have a type of non Hodgkin lymphoma called ‘primary mediastinal large B cell lymphoma’ (PMBL)
  • Have a protein called ‘CD20' on your lymphoma cells
  • Have the main part of your lymphoma in the front of the part of your chest called the mediastinum Open a glossary item - you can check this with your doctor
  • Have not had treatment for lymphoma before (if you have taken steroids for one week to control symptoms you may still be able to take part - please note: you must never stop steroid treatment without talking to your doctor first)
  • Have satisfactory blood tests
  • Are well enough to take part
  • Are willing to have PET scans
  • Are willing to use reliable contraception if there is any chance that you or your partner could become pregnant
  • Are at least 18 years old

You cannot enter this study if you

  • Have had heart problems not related to your lymphoma in the 12 months before you start the study
  • Have HIV
  • Are pregnant or breastfeeding

Trial design

This study will recruit around 120 patients from centres around the world. Everyone in the study will have 2 PET scans, and give their permission for the research team to study a stored tissue sample of their lymphoma. The chemotherapy treatment you will be having is not part of the study.

You will have your first PET scan either before your first chemotherapy treatment, or within 2 weeks of starting treatment. You must not have food or sugary drink for 6 hours before the scans, as this could affect the results. You then have an injection into a vein of a radioactive drug (tracer) called FDG. The amount of radiation is very small and shouldn’t cause any side effects. An hour later you have your PET scan, which will take between 30 and 60 minutes.

You repeat the PET scan when you finish your course of chemotherapy.

The staff may give you a mild sedative Open a glossary item tablet to relax the muscles in your neck. This will make the scan clearer. The sedative may make you a little sleepy, so you should ask someone to drive you home after the scan.

The researchers will also ask if they can study a small sample of the lymphoma tissue taken before your diagnosis. The cell samples and medical information from this study will be treated anonymously, so no one will be able to link your results to you.

Hospital visits

You will make 2 extra visits to the hospital for your study PET scans.

Side effects

The dose of radiation you have with each PET scan is about the same as having a CT scan of your chest.

We have more about chemotherapy for non Hodgkin lymphoma.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Professor Peter Johnson

Supported by

Cancer Research UK
Experimental Cancer Medicine Centre (ECMC)
International Extranodal Lymphoma Study Group (IELSG)
NIHR Clinical Research Network: Cancer
University Hospital Southampton NHS Foundation Trust
University of Southampton Clinical Trials Unit

Other information

This is Cancer Research UK trial number CRUKE/06/035.

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:

Oracle 2133

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Over 60,000 cancer patients enrolled on clinical trials in the UK last year.

Last reviewed:

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