A study to find out more about the causes of lung cancer (ReSoLuCENT)

Please note - this trial is no longer recruiting patients. We hope to add results when they are available.

Cancer type:

Lung cancer





This study is collecting information to help find out more about possible causes of lung cancer that are related to your genetic make up or your surroundings.

More about this trial

There are several known risk factors for lung cancer. Smoking is the most significant. But there are other risk factors such as the environment you live or work in, or a family history. In this study, the research team will collect blood samples and information about lifestyle from people with lung cancer, and their partners and relatives.

The research team plan to study the information in the questionnaires and the genetic material (DNA) in the blood samples. They hope to find out which factors and genetic changes are important in the development of lung cancer.

The aim of this study is to set up a store of information about genetic and lifestyle factors for people with lung cancer and their partners and relatives. This will help the researchers find out more about what causes lung cancer and what doesn’t.

You won’t get any direct benefit from taking part in this trial, nor will it affect any treatment you have. But it will help to find out more about the causes of lung cancer.

Who can enter

You can enter this trial if you have lung cancer or you need to have an operation for suspected lung cancer. As well as this you can enter this trial if you

  • Are 60 years old or less, OR
  • Have a first degree relative aged 60 or less who has lung cancer, OR
  • Have two or more first or second degree relatives of any age who have lung cancer

You may be able to be in the ‘control’ group if you

  • Are the partner of someone taking part in the study, OR
  • Are a first degree relative of someone taking part in the study, and are at least 18 years old

A first degree relative is a parent, child, brother or sister. A second degree relative is an aunt, uncle, grandchild or grandparent, for example.

Trial design

This study will recruit about 2,500 people altogether. This will be about 1,000 people with lung cancer, and about 1,500 relatives or partners who don’t have lung cancer (the control group).

If you have lung cancer and are eligible to take part, a member of the research team will contact you to see if you would like to be involved.

If you agree to take part, the researchers will ask you about a number of factors in a questionnaire. They will ask you about things such as

  • Your and your family’s medical history
  • Where you live and work
  • If you smoke or drink alcohol

They will also take a blood sample. This will be stored. The research team will look at the genetic material in the laboratory at a later date. They would also like to look at your medical notes to get precise information about your diagnosis and treatment.

The research team will ask you if you have a partner or any relatives that may be interested in taking part in this study. If so, they would also like to ask them a few questions and take a blood sample.

Hospital visits

You will fill out the questionnaire with the research nurse either at the hospital or at home. They will take the blood sample at the same time. Apart from that, you won’t have to make any extra trips to the hospital as part of this trial.

If you have lung cancer, your treatment and hospital appointments will carry on as usual.

Side effects

As there are no treatments involved in this trial, there are no side effects. You may get a small bruise when the blood sample is taken.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Professor P Woll

Supported by

Experimental Cancer Medicine Centre (ECMC)
NIHR Clinical Research Network: Cancer
Weston Park Hospital Cancer Research Trust Fund

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:


Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Cara took part in a clinical trial

A picture of Cara

"I am glad that taking part in a trial might help others on their own cancer journey.”

Last reviewed:

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