"I am glad that taking part in a trial might help others on their own cancer journey.”
A study looking at a test for examining lymph nodes during surgery for a gynaecological cancer (PIONIR)
Please note - this trial is no longer recruiting patients. We hope to add results when they are available.
More about this trial
Cancer cells can spread to lymph nodes through the normal circulation of body fluid. So if you have surgery to remove a cancer, the surgeon may also remove all the lymph nodes closest to it. The only way to find out if lymph nodes contain cancer is for a
This study is looking at a new camera test to see if it can help surgeons see which lymph nodes are the first to take up fluids draining from the cancer. Doctors call these lymph nodes sentinel nodes. During surgery, the study team will inject a dye into the cancer. This dye shines brightly under infrared light, showing the surgeon which nodes are the sentinel nodes.
The aim of the study is to see if using the dye and camera lets surgeons clearly see the sentinel nodes. In future, these sentinel nodes could then be tested for cancer during surgery. But in this study everyone will have all nearby lymph nodes removed, which is standard treatment. You will not have any direct benefit from taking part in this study, and it is unlikely to change your treatment plan in any way. But the results of the study will be used to help women with a gynaecological cancer in the future.
Who can enter
You may be able to enter this study if you have any of the following cancers
- Vulval cancer (any stage apart from stage 1A1)
- Cervical cancer (stages 1A1 to 2A)
- Womb (endometrial cancer) - stages 1A (grades 2 and 3), stage 1B (grades 2 and 3) or stage 1C or you do not have any of these stages or grades but you are due to have your lymph nodes removed
and you are
- Due to have surgery to remove your cancer and lymph nodes around it
- At least 18 years old
You cannot enter this study if you
- Are pregnant
- Are allergic to shellfish or the dye used in this study – you can check this with your doctor
- Have had chemotherapy
- Have had radiotherapy or surgery to the lymph nodes the team want to look at in this study
- Are not happy for the team to tell your GP that you are taking part in this study
- Have any other condition that may affect you or the results of the study if you took part
This study will recruit up to 60 women.
Everyone will have routine surgery as planned. Once you are asleep under
They will film the procedure and take pictures of nodes before and after they are removed. You then have all nearby lymph nodes removed as normal. These are sent to the pathologist, who will check whether or not they contain cancer cells.
The study team will also ask permission to collect information from your medical notes about your cancer.
As the study procedure happens during your surgery, you will not need to make any extra hospital visits to take part.
It is possible that you may have an allergic reaction to the dye used to show up your sentinel nodes. If this happens, the staff looking after you will give you medication to treat it.
You can find out more about surgery for different women’s cancers in the individual section for each cancer type.
How to join a clinical trial
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Professor Ahmed Ahmed
Cancer Research UK
Engineering and Physical Sciences Research Council (EPSRC)
Experimental Cancer Medicine Centre (ECMC)
Oxford Cancer Imaging Centre
University of Oxford