Around 1 in 5 people diagnosed with cancer in the UK take part in a clinical trial.
A study looking at individual and targeted radiotherapy for non small cell lung cancer
Please note - this trial is no longer recruiting patients. We hope to add results when they are available.
This study is looking at a more individual and targeted way of giving radiotherapy to treat non small cell lung cancer. The study is for people who have lung cancer that can’t be removed with surgery. This study is supported by Cancer Research UK.
More about this trial
Intensity modulated radiotherapy (IMRT) is a type of radiotherapy that doctors can use to target the cancer better. They can give a higher dose of radiotherapy to the cancer while giving as little as possible to nearby organs. The researchers will also work out the dose of radiotherapy on an individual basis.
About a month after completing chemotherapy you will have radiotherapy twice a day.
The aims of this study are to find out
- If it is practical to give an individual dose of radiotherapy that is more targeted
- What the side effects are
- If this treatment can stop lung cancer from continuing to grow or coming back
- If the treatment can help people with lung cancer to live longer
Who can enter
You may be able to enter this study if you
- Have non small cell lung cancer that can’t be removed with surgery (stage 3)
- Have had at least 2 treatments of
- Are able to have radiotherapy and start treatment within 5 weeks of having your last chemotherapy treatment
- Are well enough to be up and about for at least half the day (performance status 0, 1 or 2)
- Are at least 18 years old
You cannot enter this study if you are able to have chemotherapy at the same time as radiotherapy (
You have radiotherapy twice a day for up to 4½ weeks. Each treatment takes about 15 minutes. Each day you have a 6 hour break between treatments. You can go home during the break if you live close enough. If you stay at the hospital, you can use the hospital facilities which may include a cafeteria, relaxation room or gardens. The staff can advise you about this.
You see the doctor and have some tests before taking part in this study. These include
- A physical examination
- Blood tests
- Heart trace (
- Breathing tests (
lung function tests)
- CT scan
- Bone scan (if needed)
- PET-CT scan
- CT scan or MRI scan of your brain (if needed)
After treatment you see the doctor each week until any side effects have gone. You then see them
- A month later
- At 4 months and 8 months
- At the end of the first year
- Every 6 months for another 4 years
At each visit you have a physical examination. You have a CT scan every 4 months for 2 years after treatment.
How to join a clinical trial
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Professor Corinne Faivre-Finn
British Lung Foundation
Cancer Research UK
Experimental Cancer Medicine Centre (ECMC)
NIHR Clinical Research Network: Cancer
The Christie NHS Foundation Trust