A study looking at individual and targeted radiotherapy for non small cell lung cancer

Please note - this trial is no longer recruiting patients. We hope to add results when they are available.

Cancer type:

Lung cancer
Non small cell lung cancer





This study is looking at a more individual and targeted way of giving radiotherapy to treat non small cell lung cancer. The study is for people who have lung cancer that can’t be removed with surgery. This study is supported by Cancer Research UK.

More about this trial

When doctors can’t use surgery to remove non small cell lung cancer, they generally treat it with chemotherapy and radiotherapy.

Intensity modulated radiotherapy (IMRT) is a type of radiotherapy that doctors can use to target the cancer better. They can give a higher dose of radiotherapy to the cancer while giving as little as possible to nearby organs. The researchers will also work out the dose of radiotherapy on an individual basis.

About a month after completing chemotherapy you will have radiotherapy twice a day.

The aims of this study are to find out

  • If it is practical to give an individual dose of radiotherapy that is more targeted
  • What the side effects are
  • If this treatment can stop lung cancer from continuing to grow or coming back
  • If the treatment can help people with lung cancer to live longer

Who can enter

You may be able to enter this study if you

  • Have non small cell lung cancer that can’t be removed with surgery (stage 3)
  • Have had at least 2 treatments of platinum chemotherapy Open a glossary item
  • Are able to have radiotherapy and start treatment within 5 weeks of having your last chemotherapy treatment
  • Are well enough to be up and about for at least half the day (performance status 0, 1 or 2)
  • Are at least 18 years old

You cannot enter this study if you are able to have chemotherapy at the same time as radiotherapy (chemoradiation Open a glossary item) to treat your non small cell lung cancer.

Trial design

This is a pilot study. It will recruit 35 people. Everyone will have their radiotherapy individually planned.

You have radiotherapy twice a day for up to 4½ weeks. Each treatment takes about 15 minutes. Each day you have a 6 hour break between treatments. You can go home during the break if you live close enough. If you stay at the hospital, you can use the hospital facilities which may include a cafeteria, relaxation room or gardens. The staff can advise you about this.

Hospital visits

You see the doctor and have some tests before taking part in this study. These include

  • A physical examination
  • Blood tests
  • Heart trace (ECG Open a glossary item)
  • Breathing tests (lung function tests Open a glossary item)
  • CT scan
  • Bone scan (if needed)
  • PET-CT scan
  • CT scan or MRI scan of your brain (if needed)

After treatment you see the doctor each week until any side effects have gone. You then see them

  • A month later
  • At 4 months and 8 months
  • At the end of the first year
  • Every 6 months for another 4 years

At each visit you have a physical examination. You have a CT scan every 4 months for 2 years after treatment.

Side effects

The most common side effects of radiotherapy to the chest can include

We have information about radiotherapy for lung cancer.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Professor Corinne Faivre-Finn

Supported by

British Lung Foundation
Cancer Research UK
Experimental Cancer Medicine Centre (ECMC)
NIHR Clinical Research Network: Cancer
The Christie NHS Foundation Trust

Other information

This is Cancer Research UK trial number CRUK/12/035.

We have more information about the work of Professor Corinne Faivre-Finn.

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:


Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Around 1 in 5 people take part in clinical trials

3 phases of trials

Around 1 in 5 people diagnosed with cancer in the UK take part in a clinical trial.

Last reviewed:

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