Around 1 in 5 people diagnosed with cancer in the UK take part in a clinical trial.
A study looking at genetic testing in ovarian cancer (GTEOC)
Please note - this trial is no longer recruiting patients. We hope to add results when they are available.
This study is looking at whether it would be acceptable and practical to test women for inherited gene changes after they have been diagnosed with common types of cancer of the ovary.
We know that some women develop cancer of the ovary because they have
Women are usually only offered gene testing (genetic testing) if they have a strong family history of ovarian cancer, or breast cancer, or both. But this approach misses some women. In this study, researchers will look for inherited gene changes in the most common types of ovarian cancer. If everyone diagnosed with these types of ovarian cancer was screened for inherited gene changes, it could help the relatives of those who were found to have a gene change. This is because they may carry the same gene change and have a greater risk of ovarian and breast cancer, but not be aware of it.
The team will recruit women who have recently been diagnosed with cancer of the ovary, cancer of the fallopian tube or primary peritoneal cancer. Everyone will give a sample of blood or spit (saliva), so that the study team can test for inherited gene changes. The aim of this study is to see how acceptable and practical it is to offer genetic testing to women when they are diagnosed with ovarian cancer.
Who can enter
You may be able to enter this study if you live in the East Anglia area and you
- Have been diagnosed with either cancer of the ovary , primary peritoneal cancer or fallopian tube cancer in the last 12 months
- Are at least 18 years old
You cannot enter this study if you would not be able to understand what it involves for any reason.
This pilot study will recruit about 400 women. When you join the study the team will send you a
The team will test DNA in your sample for changes to genes called BRCA1 and BRCA2, which are strongly related to ovarian and breast cancer. If they find an inherited change, they will arrange to see you at an NHS genetics clinic. There you will be able to discuss in more detail what this means for you.
If they don’t find any changes, they will write back to you and your doctors. They will then test your sample for changes to other genes that have been linked with ovarian cancer. If these next tests show a gene change, you will also have an appointment to discuss it at an NHS genetics clinic.
The team will ask if you would fill out some more short questionnaires. These will ask about how you felt about the genetic testing. They will also ask for your permission to check information from the NHS and the National Cancer Registration Service each year to see how you are getting on.
They may also ask if they can keep in touch with you to let you know about any future research they may be doing.
You give your study blood sample at your next routine blood test. You may need to make an extra visit to hospital to discuss your blood or saliva test results.
You may find out that you have an inherited change to one of your genes. This may mean that you have a higher risk of getting other cancers (especially breast cancer) than people without this inherited change. Or, the team may find a change that they do not fully understand at the moment. If either of these happen, they will talk to you about what they have found. The NHS genetics service will also fully support you and offer you information and advice.
You may have a bruise where you gave your blood sample.
How to join a clinical trial
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Dr Marc Tischkowitz
Cambridge University Hospitals NHS Foundation Trust
NIHR Clinical Research Network: Cancer
Target Ovarian Cancer