A study looking at developing a device to help doctors better understand about blood clots in people with cancer

Please note - this trial is no longer recruiting patients. We hope to add results when they are available.

Cancer type:

Ovarian cancer





This study is collecting tissue samples to help develop a device that can give information about what makes clots happen, and how treatment may affect blood clots developing.

Deep vein thrombosis (DVT) is a blood clot that develops in the deep veins of the body. It is also sometimes called venous thromboembolism (VTE). A blood clot can be very serious if it starts to move through your body because it can end up causing a blockage in your heart or lungs, although this is not common. Most clots can be successfully treated so it is important that you report any symptoms to your doctor or nurse immediately.

We know that people with cancer have a higher risk of blood clots. These may be caused by the cancer itself, or by treatment such as chemotherapy or surgery. Researchers in this study want to develop a device to help doctors understand more about this. The device would be able to monitor individual tumour samples, and identify factors that may show that clotting could become a problem for the patient. They also want to develop a laboratory system that can study how different cancer treatments affect the development of clots. To help them develop this device, they will collect samples of blood and tissue from women having surgery for ovarian cancer.

The main aim of this study is to try to create the best conditions possible to help maintain the ovarian cancer samples in this device, so that they can be studied for several days. You will not have any direct benefit from taking part in this study. But the results of the study will be used to help people with cancer in the future.

Who can enter

You may be able to enter this study if you

  • Have cancer of the ovary
  • Are due to have surgery to remove cancer
  • Are at least 18 years old

Trial design

This study will recruit up to 80 women.

Everyone taking part will be due to have surgery as part of their ovarian cancer treatment. This is not part of the study.

For the study you give 2 small blood samples (about 1 and a half teaspoons) before your surgery. This will be at the same time as your routine blood tests, so you won’t need to have an extra needle for these.

You also give permission for the team to take a small sample of the tissue removed during your surgery.

The team will treat your samples anonymously, so no one will be able to link the results to you.

Hospital visits

You will not need to make any extra hospital visits to take part in this study.

Side effects

You will not have any side effects as a result of taking part in this study.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Professor John Greenman

Supported by

Hull and East Yorkshire NHS Trust
NIHR Clinical Research Network: Cancer

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:

Oracle 10320

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Wendy took part in a new trial studying the possible side effect of hearing loss

A picture of Wendy

"I was delighted to take part in a clinical trial as it has the potential to really help others in the future.”

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