A study looking at a combination of treatments for weight and muscle loss in people with lung or pancreatic cancer (pre MENAC)

Please note - this trial is no longer recruiting patients. We hope to add results when they are available.

Cancer type:

Lung cancer
Non small cell lung cancer
Pancreatic cancer




Phase 2

This study is looking at possible treatments for a condition called cachexia, in people with non small cell lung cancer and pancreatic cancer.

If you have cancer you may find that you lose your appetite, lose weight and have extreme tiredness (fatigue). You may hear this called cachexia (pronounced kak-ex-ee-a). At the moment, there is no standard treatment for this condition.

In this study, researchers are looking at possible treatments for cachexia.  These are

  • Advice about exercise and diet
  • A supplement drink
  • A non steroidal anti inflammatory drug Open a glossary item called celecoxib

The aim of the study is to see if the combination of these treatments helps people with weight loss, lack of appetite and fatigue.

Who can enter

You may be able to enter this study if

  • You have a type of lung cancer called non small cell lung cancer Open a glossary item that is stage 3 or 4 or cancer of the pancreas that your doctors don’t think can be cured
  • You are due to start chemotherapy, with or without radiotherapy
  • You are able to care for yourself but not able to carry on with all your normal activities or do active work (Karnofsky  performance score of more than 70)
  • You are willing to use reliable contraception during the study if there is a chance that you or your partner could become pregnant
  • Your doctor thinks you would be fit enough to take part in this study for 2 months
  • You are between 18 and 75 years of age

Trial design

This is a phase 2 study. It is randomised. The people taking part are put into groups randomly. Neither you nor your doctor will be able to decide which group you are in.

If you are in group 1, you will take action to improve your physical condition over 6 weeks by

  • Having advice about the best way to make sure you eat enough food
  • Drinking a special supplement drink twice a day
  • Following advice on exercises to make your upper body and legs stronger, and being encouraged to walk for 30 minutes twice a week (you do not need to be in good physical shape to take part in this study)
  • Taking the drug celecoxib 3 times a day

During your study visits, the team will ask you questions about

  • Your quality of life Open a glossary item
  • What you eat
  • How active you are
  • Any symptoms you may have

You will also have several blood tests during the study, so that researchers can learn more about cancer and cachexia.

If you are in group 2, you will not have this extra support straight away. This is so that the study team can see if the extra support people have in group 1 makes a difference.  After 6 weeks, when the team have compared information, you will also have this extra support for the same length of time.

Doctors will also use information collected from everyone’s routine CT scans to help them in the study.

After you finish the study, you may be able to carry on having the supplement drink along with advice about diet and exercise if your doctor thinks it helped you.

Hospital visits

Whichever group you are in, you will be in the study for about 12 weeks altogether (but people in group 2 will wait for 6 weeks to start the study once they have agreed to join). During the 12 weeks, you will need to visit the hospital between 3 and 5 times to see the study doctor and nurse, and also a physiotherapist and dietitian. The first study visit will take about 2 hours, but visits after this should take less time. Where possible, the team will arrange these visits to be at the same time as your routine hospital appointments.

The study team will pay for your travel for these appointments.

Side effects

Side effects of celecoxib include

  • High blood pressure
  • Swelling or puffiness of your arms, legs or face (fluid retention)
  • Dizziness
  • Problems sleeping
  • Stomach ache
  • Diarrhoea
  • Stomach ulcer
  • Possible risk of heart problems

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Dr Barry Laird

Supported by

Beatson West of Scotland Cancer Centre
European Palliative Care Research Centre
Experimental Cancer Medicine Centre (ECMC)
NHS Greater Glasgow and Clyde
Norwegian University of Science and Technology

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:

Oracle 9882

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Cara took part in a clinical trial

A picture of Cara

"I am glad that taking part in a trial might help others on their own cancer journey.”

Last reviewed:

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