A study looking at blood vessel cells in the bloodstreams of women having chemotherapy for ovarian, primary peritoneal or fallopian tube cancer

Cancer type:

Ovarian cancer

Status:

Results

Phase:

Other

This study looked at cells that have broken away from blood vessels Open a glossary item as a possible way of monitoring 

  • ovarian cancer
  • primary peritoneal cancer
  • fallopian tube cancer

More about this trial

Cancers need a blood supply to help them grow and survive. So growing cancers encourage the growth of new blood vessels. This is called angiogenesis.

New drugs (anti angiogenics) are being developed that will block this process. But they don’t work for everyone. At the moment the only way doctors can tell if these drugs are working is by looking at a CT scan after you’ve had treatment. They need to develop other tests that show if anti angiogenics are working earlier than this.

A way to do this may be by looking at damaged blood vessel lining cells that are released into the bloodstream. These lining cells are called endothelial cells, so those in the bloodstream are called circulating endothelial cells (CECs).

Researchers have found that increased numbers of CECs in people with cancer may be a sign (biomarker) that new blood vessels are being formed. If the number of CECs drops during treatment, it could show that anti angiogenic treatment is working.  

Researchers wanted to measure this when people were having a chemotherapy called paclitaxel. Paclitaxel blocks blood vessel growth. They wanted to look at the effect of paclitaxel chemotherapy on the number of CECs.

If they could see that paclitaxel reduces the number of CECs, this could also be a way of measuring how well other anti angiogenic drugs are working in future.

They will also wanted to look for other related biomarkers Open a glossary item in these blood samples, and see how all these link to how well the treatment works. 

Summary of results

The researchers were unable to get enough people to take part. So there will be no results for this study. 

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Professor Gordon Jayson

Supported by

Experimental Cancer Medicine Centre (ECMC)
The Christie NHS Foundation Trust

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Last review date

CRUK internal database number:

Oracle 5928

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Wendy took part in a new trial studying the possible side effect of hearing loss

A picture of Wendy

"I was delighted to take part in a clinical trial as it has the potential to really help others in the future.”

Last reviewed:

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