Last year in the UK over 60,000 cancer patients enrolled on clinical trials aimed at improving cancer treatments and making them available to all.
A study looking at who is more likely to have radiotherapy side effects (REQUITE)
This study is trying to work out which patients who have radiotherapy are more likely to have side effects than others. The people taking part have one of the following cancers
About half of all people diagnosed with cancer have radiotherapy as part of their treatment. Radiotherapy uses
People vary in how sensitive they are to radiation. About 5 out of every 100 patients (5%) are more at risk of having radiotherapy side effects than other people.
In recent years, researchers have been developing ways of trying to work out which people are very sensitive to radiation, before they start treatment. This includes looking for body substances they can measure (
In this study, researchers want to test these new methods and biomarkers thoroughly so that they may be used in the future.
Please note - taking part in the study will not change your treatment and it is unlikely to benefit you directly.
Who can enter
You may be able to join this study if you are over 18 and in one of the following situations
- You have been diagnosed with breast cancer or DCIS and are going to have radiotherapy to your whole breast after surgery to remove just the area of cancer
- You have been diagnosed with prostate cancer and are going to have external radiotherapy or internal radiotherapy (brachytherapy)
- You have been diagnosed with lung cancer and are going to have radiotherapy to try to cure your cancer, or a combination of chemotherapy and radiotherapy (chemoradiotherapy) or stereotactic radiotherapy
You cannot join this study if any of these apply. You
- Have cancer that has spread to another part of your body
- Have had any other type of cancer in the past apart from non melanoma skin cancer
- Have already had radiotherapy to the same part of your body that is going to be treated now
- Are going to have
- Are not well enough to take part because you have other medical problems
- Are known to have HIV or hepatitis
- Are pregnant
As well as the above, if you have breast cancer, you can’t take part if you
- Are male
- Have cancer in both breasts
- Have had surgery to remove you whole breast (a mastectomy)
- Are having chemotherapy at the same time as radiotherapy (you can take part if you had chemotherapy before surgery)
- Are having radiotherapy to only part of your breast
- Have breast implants (unless they are removed during surgery)
This is an international study taking place in many countries. The researchers need 5,300 people to take part.
If you take part, you will see a member of the research team at the beginning of your cancer treatment. They will ask you to complete some questionnaires asking about any symptoms you have and about your general wellbeing.
They will ask you to complete the same questionnaires again when your radiotherapy is finished and then at routine follow up appointments. These will be at least once a year for two years or more after your treatment.
They will also ask you to give a blood sample. If possible, they will collect the sample when you are having other blood tests as part of your standard treatment or follow up.
If you are having treatment for breast cancer, the study team may ask your permission to take photographs of your breasts at the beginning or your treatment and again 2 years later. This will help them to assess any changes to your breast. It will not be possible to identify you from the photographs as they will not include your face.
The study team will also look at your medical notes to collect information on your cancer and your treatment. All this information will be
It takes about 20 minutes each time you complete a questionnaire. You can do this during your routine hospital appointments, or you can finish filling in the questionnaire at home.
You may have a bruise where the blood sample is taken.
How to join a clinical trial
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Professor Catharine West
European Commission’s FP7 health programme
Experimental Cancer Medicine Centre (ECMC)
NIHR Clinical Research Network: Cancer
University of Manchester