"Health wise I am feeling great. I am a big supporter of trials - it allows new treatments and drugs to be brought in.”
A study looking at the genetic causes of prostate cancer - UK Genetic Prostate Cancer Study (UKGPCS)
More about this trial
Previous research has suggested that if a man has a family history of prostate cancer this will increase his risk of developing this disease. This study aims to increase our understanding of the genetic causes of prostate cancer.
It is hoped that the information gained from this trial will help the researchers to
- Find out how many families have a strong family history of prostate cancer
- Work out a man’s risk of developing prostate cancer if he has a family history
- Find out if a man’s family history of prostate cancer also increases his risk of developing other cancers
- Identify other faulty genes that can increase a man’s risk of developing prostate cancer (we already know about BRCA1 and BRCA2)
- Establish a storage bank of blood, saliva and tumour samples that may help future research
In the long term, the results of this study may help to find ways to diagnose prostate cancer early and to prevent prostate cancer in some men.
Who can enter
All patients with prostate cancer at the Royal Marsden Hospital are asked to become part of this study.
If you are a patient elsewhere you can enter the study if you
- Have prostate cancer and also have a first, second or third degree relative who has been diagnosed with prostate cancer and one of you was diagnosed at 65 or under OR
- Are one of three or more members on the same side of your family with prostate cancer diagnosed at any age
This study is recruiting 26,000 patients and is being run by the Royal Marsden Hospital. If you are a prostate cancer patient at the Royal Marsden Hospital you will automatically be asked to take part in this study.
If you are not a patient at the Royal Marsden and you think you may be eligible for this study, you can refer yourself. The researchers ask that you talk to your specialist (hospital consultant) first. This is because your specialist will be asked to provide details of your cancer and it’s treatment if you take part in this study.
You can refer yourself by writing to the Study Co-ordinators, explaining why you think you may be able to take part. Their address is The UK Genetic Prostate Cancer Study, Institute of Cancer Research & The Royal Marsden NHS Trust, Downs Road, Sutton, Surrey, SM2 5NG.
If you take part, you will be sent a questionnaire in the post. This will ask questions about your family, such as their names, dates of birth and any illnesses they have had. It is important to check with members of your family that they are happy for you to do this. If you are concerned about giving personal information about your relatives you may give anonymous information about them. Members of your family will never be contacted without your permission.
You will be asked for a saliva sample and you may also be asked to give a small sample of blood. If you are asked for a blood sample this may be taken at your GP surgery or hospital, depending on how your local services are arranged. The DNA from the blood and saliva samples will be stored in a DNA bank. The researchers will look at all the DNA to try to find faulty genes that may be related to prostate cancer. These results will be compared with other DNA samples. The DNA samples are taken for the purposes of this study only. This should not affect your right to apply for insurance, such as life or medical insurance.
The researchers may also ask your hospital for a sample of your cancer tissue, taken during your original prostate biopsy or operation. This sample will be stored and may be used for future studies.
There is more information about this study on the UK Genetic Prostate Cancer Study website.
Taking part in this study does not involve any extra visits to your hospital. If you are having treatment for your prostate cancer, this will not affect your medical care.
If you give a blood sample you may have some bruising in the area where this is taken. There are no other side effects associated with taking part in this study.
How to join a clinical trial
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Prof R. Eeles
Cancer Research UK
Institute of Cancer Research (ICR)
NIHR Clinical Research Network: Cancer
National Cancer Research Institute (NCRI)
National Institutes of Health (NIH)
Prof Eeles' Research Fund
Prostate Cancer UK