A study looking at Phyllodes breast tumours

Please note - this trial is no longer recruiting patients. We hope to add results when they are available.

Cancer type:

Breast cancer





This study is looking at a rare type of tumour called Phyllodes tumour that generally occur in the breast. They can be either cancerous (malignant) or non cancerous (benign). They are usually treated with surgery and sometimes radiotherapy. These tumours do not usually come back (recur) after treatment, although they occasionally recur in some people.

The researchers will collect tumour samples and blood samples from people who have been diagnosed with a Phyllodes tumour. They will use these samples

  • To try to identify genes that may be important in the development of these tumours
  • To try to understand why some tumours come back and some do not

The results of this study will hopefully increase our understanding of Phyllodes tumours and benefit patients in the future.

Who can enter

You can enter this trial if you have been diagnosed with a Phyllodes tumour of the breast and you have had surgery to remove this, or you are due to have surgery to remove this

Trial design

This study aims to recruit 500 people with a Phyllodes tumour of the breast. The researchers will ask some people to take part who are going to have an operation to remove their Phyllodes tumour. They will also write to people who have had treatment for Phyllodes tumour in the past, asking them if they will take part.

If you are not a patient at one of the recruiting hospitals and you are interested in taking part, you may be able to. You could discuss this with your own consultant and ask them to refer you to the Chief Investigator of this study.

If you take part, the researchers will ask for your permission to collect some tissue from your tumour and some of the surrounding normal tissue. The tissue may be from a biopsy Open a glossary item or operation you are due to have, or have had in the past. They will also ask you to have a blood test. The researchers need about 2 tablespoons of blood (about 10 to 25 mls). This is in addition to blood tests that you might have as part of your treatment.

The research team will look at your tissue and blood samples to find information about the DNA and any genetic changes that might be present. They will also use some of the tissue samples to try to grow the tumour cells in the laboratory to see how the cells behave.

Hospital visits

Taking part in this study will probably not involve any extra hospital visits. The researchers will try to arrange for you to have your blood test when you are an in patient, or when you are due to go to hospital for other tests (as part of your treatment).

If you are not due to visit hospital, the research team will ask you to go to your GP surgery to have your blood test. A blood test pack will be posted out to you and you just need to give this to your GP or practice nurse.

Side effects

Taking part in this study will not affect your treatment for Phyllodes tumour and will not change your medical care in any way. You may have an extra blood test as a result of taking part. But if possible, this will be arranged so that blood is taken when you are due to have other blood tests, as part of your treatment. Your blood tests may cause some bruising to the skin.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Professor I. Tomlinson

Supported by

Department of Health

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:

Oracle 841

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Harriet wanted to try new treatments

Picture of Harriet

“I was keen to go on a clinical trial. I wanted to try new cancer treatments and hopefully help future generations.”

Last reviewed:

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