A study looking at differences in platelets and how well they work when given as a platelet transfusion (PROmPT)

Please note - this trial is no longer recruiting patients. We hope to add results when they are available.

Cancer type:

All cancer types





This is a study to see if differences in blood cells called platelets affect how well they work when given to somebody as a transfusion Open a glossary item.

Platelets are a type of blood cell. They are very important in blood clotting and help to stop bleeding. If the number of platelets in your blood is low you may bruise easily, have nosebleeds or bleed more than usual from cuts or grazes.

The number of platelets you have may go down when you have cancer treatment such as chemotherapy. If the number of platelets you have gets very low, you may need to have platelets from a donor. You have them through a drip into a vein.

Platelets need to be ‘switched on’ to help with blood clotting. How easily platelets are switched on is called responsiveness. When they are tested in the laboratory, platelets from different donors have different levels of responsiveness. Researchers want to find out if these levels make any difference when the platelets are given to another person as a platelet transfusion.

The people taking part in this study are having platelet transfusions as part of their treatment.

Who can enter

You may be able to enter this trial if you

  • Are having treatment at Addenbrooke’s Hospital
  • Have a low platelet count and need to have platelet transfusions
  • Are at least 16 years old

You cannot enter this trial if you

  • Have a medical condition that affects how your platelets work or how your blood clots
  • Have a type of leukaemia called acute promyelocytic leukaemia
  • Have had serious bleeding problems
  • Have a large spleen Open a glossary item that your doctor can feel when they examine you
  • Have an immune response Open a glossary item that stops platelet transfusions working for you
  • Need to have platelets that are especially matched for you
  • Have had another type of cancer in the last 5 years
  • Are pregnant or breastfeeding

Trial design

If you agree to take part in this study, your doctor will let the study team know when you need to have a platelet transfusion.

They will arrange for you to have a transfusion of platelets from a donor who the researchers have tested to see if their platelets have a high level or a low level of responsiveness.

Platelets must be a suitable match for you. If there are no suitably matched study platelets available, you will have a transfusion of non study platelets as normal. The researchers will try to give you study platelets again next time you need a platelet transfusion.

A member of the study team will take a blood sample before you have the platelets. You then have 2 more blood tests - 1 hour and 24 hours after the transfusion. From these samples, the researchers will measure the increase in the number of platelets you have.

They will ask you to fill in questionnaires each day for 5 days after your platelet transfusion. The questionnaires ask about any bleeding problems you’ve had.

The researchers will also ask 30 people who have non study platelets to give blood samples and fill in questionnaires.

Hospital visits

Taking part in this trial does not involve any extra hospital visits. If you are no longer in hospital 24 hours after your platelet transfusion, a member of the study team will visit you at home to take the blood sample.

Side effects

As you would be having platelet transfusions anyway, there are no extra side effects from taking part in this study.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Dr Lorna Williamson

Supported by

NHS Blood and Transplant
National Institute for Health Research Cancer Research Network (NCRN)

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:

Oracle 10570

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Cara took part in a clinical trial

A picture of Cara

"I am glad that taking part in a trial might help others on their own cancer journey.”

Last reviewed:

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