A study looking at developing new treatments for cancers of the blood (MMTA Study)

Cancer type:

Blood cancers
Leukaemia
Lymphoma
Myeloma

Status:

Open

Phase:

Other

This study is looking at developing new treatments for myeloma, lymphoma, leukaemia and some other blood cancers in the laboratory.

More about this trial

Myeloma, lymphoma and leukaemia are all types of blood cancers.

  • Leukaemia Open a glossary item is blood cancer of the white blood cells
  • Lymphoma Open a glossary item is a blood cancer of the lymphatic system
  • Myeloma Open a glossary item is a blood cancer that develops from cells in the bone marrow called plasma cells

In this study, doctors want to use some of the cells from your blood and bone marrow to test the new treatment in the laboratory.

They also want blood and bone marrow from healthy volunteers who do not have a blood cancer

The aims of this study are to:

  • find out if the new drugs in the laboratory kill blood cancer cells
  • develop a new test to help treat myeloma in the future

Who can enter

You may be able to enter this trial if you:

  • are having your blood cancer  treatment at Imperial College Healthcare NHS Trust, London
  • have a blood cancer that includes myeloma, leukaemia, lymphoma, and myelodysplastic syndrome
  • Are at least 18 years old

You might be able to join as a healthy volunteer if you do not have a blood cancer, are at least 18 years old and the following also apply. 

You cannot enter this trial if you:

  • have any other illness that would make you unsuitable for the study
  • are pregnant or breastfeeding

Trial design

This study will recruit 500 people with blood cancer and 100 people without.

Everybody taking part will have a blood test and bone marrow test once a year for 5 years.

Hospital visits

If you have blood cancer, there are no extra hospital visits as part of this trial. You give blood and bone marrow samples when you see the doctor as part of your routine care.

If you are a healthy volunteer the doctors will organise your visit at a time convenient for you.

Side effects

Side effects of bone marrow tests include discomfort and bruising at your biopsy site. You may need some mild painkillers to take home or the doctor may suggest you take paracetamol. Very rarely you may also have bleeding, infection and pain.

You may have a small bruise where you had your blood test.

Location

London
Middlesex
Uxbridge

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Professor Guido Franzoso

Supported by

Imperial College Healthcare NHS Trust
Medical Research Council (MRC)
NIHR Clinical Research Network: Cancer

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:

9347

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Over 60,000 cancer patients enrolled on clinical trials in the UK last year.

Last reviewed:

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