Last year in the UK over 60,000 cancer patients enrolled on clinical trials aimed at improving cancer treatments and making them available to all.
A study looking at ADI PEG 20 to treat small cell lung cancer
Please note - this trial is no longer recruiting patients. We hope to add results when they are available.
This study is looking at ADI PEG 20 to treat small cell lung cancer.
Doctors can treat small cell lung cancer with chemotherapy. Unfortunately sometimes the cancer can continue to grow during treatment or come back afterwards. When this happens it is more difficult to treat.
Researchers have found a new way of destroying small cell lung cancer cells in the laboratory, by removing an
Our bodies can make arginine using a protein (a particular
The aims of this study are to find out
- How well ADI PEG 20 works for small cell lung cancer
- How safe it is
Who can enter
You may be able to enter this trial if
- You have small cell lung cancer
- You have had no more than 2 different courses of chemotherapy treatment for small cell lung cancer
- Your cancer continued to grow during your chemotherapy or came back afterwards
- Your cancer can be measured on a scan
- You have cancer cells that don’t have the enzyme needed for the treatment, or only a very tiny amount – the researchers will test for this
- You are well enough to be up and about for at least half the day (performance status 0, 1 or 2)
- You have satisfactory blood tests
- You are willing to use reliable contraception during the study
- You are at least 18 years old
You cannot enter this trial if
- You have already had ADI PEG 20
- You are allergic to any drugs that have been treated in the same way as this study drug (they have been
pegylated) - you can check this with your doctor
- Your cancer has spread to your brain or spinal cord – if you have had treatment for this and you have no symptoms you may be able to take part
- You have had radiotherapy or chemotherapy in the past 3 weeks (6 weeks for chemotherapy drugs called
- You have had an experimental drug as part of a clinical trial in the past 3 weeks
- You have fits (seizures) that aren’t controlled by medication
- You are known to be HIV positive
- You have a serious illness, infection or medical condition that could affect you taking part in this trial
- You are pregnant or breastfeeding
This is a phase 2 study. It will recruit up to 45 people. Everyone will have ADI PEG 20.
You have ADI PEG 20 as an injection into a muscle in your arm or leg every week. You continue having ADI PEG 20 as long as it is helping you.
If you agree to take part in this study, the researchers will ask for some samples of tissue of your cancer (
You see the doctor and have some tests before taking part in this study. These test include
- A physical examination
- Blood tests
- CT scan
During treatment you see the doctor every 2 weeks for a physical examination and blood tests. You have a CT scan every 4 to 8 weeks.
After treatment your doctor will talk to you about how often they want to see you.
Side effects of ADI PEG 20 include
- Redness and tenderness where you had the injection
- Risk of pain and inflammation in the big toe and foot (gout) – you will have blood tests, and treatment to prevent this if needed
- A drop in blood pressure
- Small fits where you lose awareness for a few moments (petit mal seizures) – these do not cause long term effects, and the team will be able to offer you suitable treatment
Your doctor will talk to you about the possible side effects before you agree to take part in this study.
How to join a clinical trial
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Dr Peter Szlosarek
Barts Health NHS Trust
Ludwig Institute for Cancer Research