A study looking at 2 new treatments for prostate cancer that does not respond to hormone therapy

Cancer type:

Prostate cancer

Status:

Results

Phase:

Phase 2

This study wanted to see if 2 drugs for diabetes and high cholesterol helped to reduce PSA levels in prostate cancer when hormone therapy was no longer working.

More about this trial

Doctors often use hormone therapy to treat prostate cancer. This treatment usually works well for a few years. But the cancers often become resistant to hormone therapy at some stage.

When this happens you may not have symptoms. But your PSA Open a glossary itemwill increase. This shows that your prostate cancer is becoming more active. Doctors may then use other treatments including steroids or chemotherapy. But these treatments often have unpleasant side effects.

Researchers wanted to see if 2 drugs designed to treat other conditions, would help to stabilise or lower the PSA.

These drugs do not have such severe side effects as steroids or chemotherapy. Pioglitazone treats diabetes, but is still safe if you are not diabetic. Fenofibrate treats high cholesterol. 

The aims of this study were to:

  • see how these drugs affect PSA levels in men with symptom free hormone resistant prostate cancer
  • find out more about the side effects
  • see how these drugs affected quality of life Open a glossary item

Summary of results

The study team have told us that this trial closed early because they found it difficult to get enough men to take part. This means that they have not been able to do a full analysis of the results.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Dr Jonathan Shamash

Supported by

Barts Health NHS Trust
Experimental Cancer Medicine Centre (ECMC)
Orchid Cancer Appeal

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:

2614

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Keith took part in a trial looking into hormone therapy

A picture of Keith

"Health wise I am feeling great. I am a big supporter of trials - it allows new treatments and drugs to be brought in.”

Last reviewed:

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