Hydroxycarbamide is a chemotherapy treatment. It might also be known by a brand name, Hydrea.
It is a treatment for:
- chronic myeloid leukaemia (CML)
- polycythaemia vera (PCV)
- essential thrombocythemia (ET)
- cervical cancer (cancer of the neck of the womb)
For cervical cancer, you usually have it in combination with radiotherapy.
How it works
Hydroxycarbamide is one of a group of chemotherapy drugs known as anti metabolites. These drugs stop cells making and repairing DNA. Cancer cells need to make and repair DNA in order to grow and multiply.
How you have it
Hydroxycarbamide comes as capsules that you swallow whole, with a glass of water. You can empty the contents of the capsules into a glass of water if you have difficulty swallowing capsules. Then drink it all straight away. Don't leave any behind in the glass.
You can take hydroxycarbamide with or without food.
Taking your capsules
You should take the right dose, not more or less.
Talk to your specialist or advice line before you stop taking a cancer drug.
If you take more hydroxycarbamide than you should
Contact your doctor or nurse straight away.
If you forget to take hydroxycarbamide
Do not take the missed dose and take your next dose at the usual time. Do not take a double dose to make up for the forgotten dose.
When you have it
You usually have hydroxycarbamide as a course of several cycles of treatment. Sometimes there might be a break between cycles.
You can have hydroxycarbamide in combination with radiotherapy. When this happens, you usually start taking hydroxycarbamide 7 days before the radiotherapy treatment.
You have blood tests before and during your treatment. They check your levels of blood cells and other substances in the blood. They also check how well your liver and kidneys are working.
We haven't listed all the side effects. It's very unlikely that you will have all of these side effects, but you might have some of them at the same time.
How often and how severe the side effects are can vary from person to person. They also depend on what other treatments you're having. For example, your side effects could be worse if you're also having other drugs or radiotherapy.
When to contact your team
Your doctor, nurse or pharmacist will go through the possible side effects. They will monitor you closely during treatment and check how you are at your appointments. Contact your advice line as soon as possible if:
- you have severe side effects
- your side effects aren’t getting any better
- your side effects are getting worse
Early treatment can help manage side effects better.
Risk of bruising and bleeding
This is due to a drop in the number of platelets in your blood. These blood cells help the blood to clot when we cut ourselves. You may have nosebleeds or bleeding gums after brushing your teeth. Or you may have lots of tiny red spots or bruises on your arms or legs (known as petechia).
Risk of infection
Increased risk of getting an infection is due to a drop in white blood cells. Symptoms include a change in temperature, aching muscles, headaches, feeling cold and shivery and generally unwell. You might have other symptoms depending on where the infection is.
Infections can sometimes be life threatening. You should contact your advice line urgently if you think you have an infection.
Breathless and looking pale
You might be breathless and look pale due to a drop in red blood cells. This is called anaemia.
Loss of appetite
You might lose your appetite for various reasons when you are having cancer treatment. Sickness, taste changes or tiredness can put you off food and drinks.
Inflammation of the pancreas
This drug can cause inflammation of the pancreas (pancreatitis). Tell your doctor straight away if you have sudden and severe pain in your tummy (abdomen).
Feeling or being sick
Feeling or being sick is usually well controlled with anti sickness medicines. Avoiding fatty or fried foods, eating small meals and snacks, drinking plenty of water, and relaxation techniques, can all help.
It is important to take anti sickness medicines as prescribed even if you don’t feel sick. It is easier to prevent sickness rather than treating it once it has started.
Diarrhoea or constipation
Tell your doctor or nurse if you have diarrhoea or constipation. They can give you medicine to help.
Mouth sores and ulcers can be painful. Keep your mouth and teeth clean; drink plenty of fluids; avoid acidic foods such as oranges, lemons and grapefruits; chew gum to keep the mouth moist and tell your doctor or nurse if you have ulcers.
Inflammation of the lining of the gut and bowel
This can cause bleeding from your back passage when pooing and blood in your poo. It can also be very painful. Contact your advice line or tell your doctor or nurse if you have any of these symptoms.
Tummy (abdominal) discomfort or pain
Tell your treatment team if you have this. They can check the cause and give you medicine to help.
You could lose all your hair. This includes your eyelashes, eyebrows, underarm, leg and sometimes pubic hair. Your hair will usually grow back once treatment has finished but it is likely to be softer. It may grow back a different colour or be curlier than before.
Skin and nail changes
Skin and nail problems include a skin rash, dry skin, itching and darker skin. Your nails may also become brittle, dry, change colour or develop ridges. This usually goes back to normal when you finish treatment.
Sore weak muscles
Your muscles might feel sore, weak and tired especially when climbing stairs, walking or getting out of a chair.
Problems passing urine
You might find it painful and difficult to pass urine. Contact your advice line or tell your doctor or nurse if this happens.
An increased level of certain substances in the blood
You might have an increased level of creatinine, urea and uric acid in the blood. You have regular blood tests to check these.
If you get a high temperature, let your health care team know straight away. Ask them if you can take paracetamol to help lower your temperature.
You might feel cold for no apparent reason. Chills can also happen when you have a high temperature
Having no energy or strength
This is usually mild. You can do things to help yourself, including some gentle exercise. It’s important not to push yourself too hard and eat a well balanced diet.
Talk to your doctor or nurse if this effect is stopping you from doing your usual daily activities.
Occasional side effects
These side effects happen in between 1 and 10 out of every 100 people (1 to 10%). You might have one or more of them. They include:
- skin ulcers especially on your legs
- skin cancer
- feeling disorientated and having hallucinations
- fits (convulsions), dizziness, headaches and feeling drowsy
- damage to the nerves in your hands and feet causing pain, tingling or numbness
- changes to your lungs included fluid on the lung and inflammation causing shortness of breath
- changes or damage to your liver
Coping with side effects
We have more information about side effects and tips on how to cope with them.
What else do I need to know?
Other medicines, food and drink
Cancer drugs can interact with some other medicines and herbal products. Tell your doctor or pharmacist about any medicines you are taking. This includes vitamins, herbal supplements and over the counter remedies.
This drug contains lactose (milk sugar). If you have an intolerance to lactose, contact your doctor before taking this medicine.
Check with your doctor to see if drinking alcohol may harm you while having this treatment.
Loss of fertility
You may not be able to become pregnant or father a child after treatment with this drugs. Talk to your doctor before starting treatment if you think you may want to have a baby in the future.
Men might be able to store sperm before starting treatment. And women might be able to store eggs or ovarian tissue. But these services are not available in every hospital, so you would need to ask your doctor about this.
Contraception and pregnancy
This drug may harm a baby developing in the womb. It is important not to become pregnant or father a child while you are having treatment with this drug and for at least 3 months afterwards. Talk to your doctor or nurse about effective contraception before starting treatment.
Don’t breastfeed during this treatment because the drug may come through into your breast milk.
Treatment for other conditions
Always tell other doctors, nurses, pharmacists or dentists that you’re having this treatment if you need treatment for anything else, including teeth problems.
Don’t have immunisations with live vaccines while you’re having treatment and for up to 12 months afterwards. The length of time depends on the treatment you are having. Ask your doctor or pharmacist how long you should avoid live vaccinations.
In the UK, live vaccines include rubella, mumps, measles, BCG, yellow fever and the shingles vaccine (Zostavax).
- have other vaccines, but they might not give you as much protection as usual
- have the flu vaccine (as an injection)
Contact with others who have had immunisations - You can be in contact with other people who have had live vaccines as injections. Avoid close contact with people who have recently had live vaccines taken by mouth (oral vaccines) such as the oral typhoid vaccine.
If your immune system is severely weakened, you should avoid contact with children who have had the flu vaccine as a nasal spray. This is for 2 weeks following their vaccination.
Babies have the live rotavirus vaccine. The virus is in the baby’s poo for about 2 weeks and could make you ill if your immunity is low. Get someone else to change their nappies during this time if you can. If this isn't possible, wash your hands well after changing their nappy.
More information about this treatment
For further information about this treatment go to the electronic Medicines Compendium (eMC) website.
You can report any side effect you have to the Medicines Health and Regulatory Authority (MHRA) as part of their Yellow Card Scheme.