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Buserelin (Suprefact)

Find out what buserelin is, how you have it and other important information about taking buserelin.

Buserelin is a hormone therapy drug and is also known by its brand name, Suprefact. 

It is a treatment for prostate cancer. 

How it works

Buserelin is a type of hormone therapy known as a LH (luteinising hormone) blocker. It stops the pituitary gland releasing luteinising hormone. This stops the testicles producing testosterone.

Prostate cancer depends on testosterone to grow. So buserelin can shrink the cancer or slow its growth. 

How you have it

You have buserelin as an injection under the skin. After several injections you have it as a nasal spray. 

You usually have injections under the skin (subcutaneous injection) into the stomach, thigh or top of your arm.

You might have stinging or a dull ache for a short time after this type of injection but they don't usually hurt much. The skin in the area may go red and itchy for a while.

The video below shows you how to give an injection just under your skin (subcutaneously). 

When you have it

You have it as an injection 3 times a day for 7 days. On the 8th day you start using buserelin as a nasal spray.

You spray the drug into each nostril 6 times a day. One way of remembering to do this is to use the spray before and after each meal. So you can have the treatment before and after breakfast, lunch and your evening meal. 

You continue taking the buserelin for as long as it is working. 

Tests during treatment

You have blood tests before starting treatment and during your treatment. They check your levels of testosterone every 3 months. They also check the levels of blood cells and other substances in the blood. Other tests see how well your liver and kidneys are working.

Side effects

Important information

Other medicines, foods and drink

Cancer drugs can interact with some other medicines and herbal products. Tell your doctor or pharmacist about any medicines you are taking. This includes vitamins, herbal supplements and over the counter remedies.

Treatment for other conditions

Always tell other doctors, nurses, pharmacists or dentists that you’re having this treatment if you need treatment for anything else, including teeth problems.


It is important not to father a child while you are having treatment with this drug and for a few months afterwards. This drug may harm a baby developing in the womb. Talk to your doctor or nurse about effective contraception before starting treatment. 

Other medical conditions

If you have diabetes, high blood pressure or depression, tell your doctor. All of these conditions can be affected by buserelin treatment. 

More information about this treatment

We haven't listed all the very rare side effects of this treatment. For further information see the electronic Medicines Compendium (eMC) website.

You can report any side effect you have that isn’t listed here to the Medicines Health and Regulatory Authority (MHRA) as part of their Yellow Card Scheme.

Information and help

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