Uterine cancer incidence statistics

Cases

New cases of uterine cancer, 2013, UK

 

Proportion of all cases

Percentage uterine cancer is of total cancer cases, 2013, UK

 

Age

Age that almost 6 in 10 of uterine cancer cases are diagnosed, 2011-2013, UK

 

Trend since 1970s

Uterine cancer incidence rates have increased since the late 1970s, GB

 

Uterine (womb) cancer is the fourth most common cancer in females in the UK (2013), accounting for 5% of all new cases of cancer in females.[1-4]

In 2013, there were 9,022 new cases of uterine cancer in the UK.[1-4] The crude incidence rate Open a glossary item shows that there are 28 new uterine cancer cases for every 100,000 females in the UK.

The European age-standardised rate Open a glossary item (AS rate) in England is significantly lower compared with Wales.[1-4] Rates do not differ significantly between the constituent countries of the UK.

Uterine Cancer (C54-C55), Number of New Cases, Crude and European Age-Standardised (AS) Incidence Rates per 100,000 Population, UK, 2013

England Wales Scotland Northern Ireland UK
Cases 7,442 542 790 248 9,022
Crude Rate 27.2 34.6 28.8 26.6 27.7
AS Rate 29.0 33.7 29.0 30.3 29.3
AS Rate - 95% LCL 28.4 30.9 27.0 26.5 28.7
AS Rate - 95% UCL 29.7 36.6 31.0 34.0 29.9

95% LCL and 95% UCL are the 95% lower and upper  confidence limits around the AS rate Open a glossary item

ASR calculated with ESP2013. Not comparable with ASRs calculated with ESP1976.

Uterine cancer incidence rates vary significantly across the former cancer networks throughout the UK with higher than average rates in Wales, Yorkshire, the Midlands and Anglia and lower than average rates in Scotland, the North West, and Southern England.[5,6]

References

  1. Data were provided by the Office for National Statistics on request, July 2015. Similar data can be found here: http://www.ons.gov.uk/ons/rel/vsob1/cancer-statistics-registrations--england--series-mb1-/index.html.
  2. Data were provided by ISD Scotland on request, April 2015. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications/index.asp.
  3. Data were provided by the Welsh Cancer Intelligence and Surveillance Unit on request, February 2015. Similar data can be found here: http://www.wales.nhs.uk/sites3/page.cfm?orgid=242&pid=59080.
  4. Data were provided by the Northern Ireland Cancer Registry on request, March 2015. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/.
  5. National Cancer Intelligence Network (NCIN). Cancer Incidence and Mortality by Cancer Network, UK, 2005. London: NCIN; 2008.
  6. National Cancer Intelligence Network (NCIN). Cancer e-Atlas. Accessed January 2014.
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Uterine cancer incidence is related to age, with the highest incidence rates overall being in females in their early 70s – a slightly different pattern to most cancers. In the UK in 2011-2013, on average each year almost 6 in 10 (58%) cases were diagnosed in females aged 65 and over.[1-4]

Age-specific incidence rates rise sharply from around age 40-44, peak in the 70-74 age group, and subsequently drop sharply.[1-4]

Uterine Cancer (C54-C55), Average Number of New Cases per Year and Age-Specific Incidence Rates per 100,000 Population, Females, UK, 2011-2013

The age distribution of uterine cancer cases probably reflects hormonal changes during and after the menopause.

References

  1. Data were provided by the Office for National Statistics on request, July 2015. Similar data can be found here: http://www.ons.gov.uk/ons/rel/vsob1/cancer-statistics-registrations--england--series-mb1-/index.html.
  2. Data were provided by ISD Scotland on request, April 2015. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications/index.asp.
  3. Data were provided by the Welsh Cancer Intelligence and Surveillance Unit on request, February 2015. Similar data can be found here:http://www.wales.nhs.uk/sites3/page.cfm?orgid=242&pid=59080.
  4. Data were provided by the Northern Ireland Cancer Registry on request, March 2015. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/.
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Uterine cancer incidence rates have increased by 65% in females in Great Britain since the late 1970s.[1-3] Most of this increase has occurred since the early 1990s.

European age-standardised Open a glossary item (AS) incidence rates remained stable between 1979-1981 and 1989-1991, then increased by 60% between 1989-1991 and 2011-2013.

Uterine Cancer (C54-C55), European Age-Standardised Incidence Rates, Females, Great Britain, 1979-2013

ASR calculated with ESP2013. Not comparable with ASRs calculated with ESP1976.

Over the last decade in the UK (between 2002-2004 and 2011-2013), uterine cancer AS incidence rates in females have increased by 25%.[1-4]

Uterine Cancer (C54-C55), European Age-Standardised Incidence Rates, Females, UK, 1993-2013

ASR calculated with ESP2013. Not comparable with ASRs calculated with ESP1976.

Uterine cancer incidence trends probably reflect changing prevalence of risk factors, with recent incidence trends influenced by risk factor prevalence in years past.

Uterine cancer incidence rates have increased overall for most of the broad age groups in Great Britain since the late 1970s, with fast increases since the early 1990s, Rates in females aged 25-49 have overall remained stable, though this includes a decrease followed by an increase since the late 1990s.[1-3]

The largest increase overall has been in females aged 70-79, with European AS incidence rates Open a glossary item doubling (105% increase) between 1979-1981 and 2011-2013. Rates also increased in females aged 60-69 and 80+ between 1979-1981 and 2011-2013 (89% and 59% increases, respectively).[1,3]

Uterine Cancer (C54-C55), European Age-Standardised Incidence Rates, Females, By Age, Great Britain, 1979-2013

ASR calculated with ESP2013. Not comparable with ASRs calculated with ESP1976.

References

  1. Data were provided by the Office for National Statistics on request, July 2015. Similar data can be found here: http://www.ons.gov.uk/ons/rel/vsob1/cancer-statistics-registrations--england--series-mb1-/index.html.
  2. Data were provided by ISD Scotland on request, April 2015. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications/index.asp.
  3. Data were provided by the Welsh Cancer Intelligence and Surveillance Unit on request, February 2015. Similar data can be found here:http://www.wales.nhs.uk/sites3/page.cfm?orgid=242&pid=59080.
  4. Data were provided by the Northern Ireland Cancer Registry on request, March 2015. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/.
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Staging completeness for uterine cancer is high in England, with 91% of uterine cancers recorded with a known stage at diagnosis in 2013.[1]

Uterine Cancer (C54), Proportion of Cases Diagnosed at Each Stage, England 2013

[graph:inc_stage_uterine]

Females diagnosed with uterine cancer with a known stage most commonly present at stage I (74%), in England. More females with a known stage are diagnosed at an early stage (82% diagnosed at stage I or II) than an advanced stage (18% diagnosed at stage III or IV). More than 1 in 20 (7%) Females have metastases Open a glossary item at diagnosis (stage IV).[1]

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Most uterine cancer cases occur in the endometrium Open a glossary item, with much smaller proportions in the myometrium, fundus uteri and isthmus uteri (2010-2012).[1-4]

A small proportion of cases did not have the specific part of the uterus recorded in cancer registry data, or overlapped more than one part.[1-4]

Uterine Cancer (C54-C55), Percentage Distribution of Cases Diagnosed By Anatomical Site, UK, 2010-2012

Cancer site (ICD-10 code) Average Cases %
Isthmus Uteri (C54.0) 5 0.1%
Endometrium (C54.1) 7,969 93.8%
Myometrium (C54.2) 31 0.4%
Fundus Uteri (C54.3) 18 0.2%
Uterus, Overlapping and Unspecified (C54.9-C55) 470 5.5%
Total 8,494 100.0%

Cases and percentages may not sum due to rounding

References

  1. Data were provided by the Office for National Statistics on request, July 2014. Similar data can be found here: http://www.ons.gov.uk/ons/rel/vsob1/cancer-statistics-registrations--england--series-mb1-/index.html.
  2. Data were provided by ISD Scotland on request, April 2014. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications/index.asp.
  3. Data were provided by the Welsh Cancer Intelligence and Surveillance Unit on request, April 2014. Similar data can be found here: http://www.wales.nhs.uk/sites3/page.cfm?orgid=242&pid=59080.
  4. Data were provided by the Northern Ireland Cancer Registry on request, June 2014. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/CancerInformation/.
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The lifetime risk of developing uterine cancer is 1 in 41 for women, in 2012 in the UK.[1]

The lifetime risk for uterine cancer has been calculated on the assumption that the possibility of having more than one diagnosis of uterine cancer over the course of a lifetime is very low (‘Current Probability’ method).[2]

References

  1. Lifetime risk estimates calculated by the Statistical Information Team at Cancer Research UK. Based on data provided by the Office of National Statistics, ISD Scotland, the Welsh Cancer Intelligence and Surveillance Unit and the Northern Ireland Cancer Registry, on request, December 2013 to July 2014.
  2. Esteve J, Benhamou E and Raymond L. Descriptive epidemiology. IARC Scientific Publications No.128, Lyon, International Agency for Research on Cancer, pp 67-68 1994.
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Uterine cancer (C54 only) is the fourth most common cancer in Europe for females, and the tenth most common cancer overall, with around 99,000 new cases diagnosed in 2012 (6% of female cases and 3% of the total). In Europe (2012), the highest World age-standardised Open a glossary item incidence rates for uterine cancer are in Macedonia; the lowest are in Greece. UK uterine cancer incidence rates are estimated to be the 20th highest in Europe.[1] These data are broadly in line with Europe-specific data available elsewhere.[2]

Uterine cancer (C54 only) is the sixth most common cancer worldwide for females, and the 14th most common cancer overall, with more than 319,000 new cases diagnosed in 2012 (5% of female cases and 2% of the total). Uterine cancer incidence rates are highest in Northern America, and lowest in South Central Asia, but this partly reflects varying data quality worldwide.[1]

Variation between countries may reflect different prevalence of risk factors, use of screening, and diagnostic methods.

References

  1. Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J, et al.Cancer incidence and mortality patterns in Europe: Estimates for 40 countries in 2012. European Journal of Cancer (2013) 49, 1374-1403.
  2. Ferlay J, Soerjomataram I, Ervik M, et al. GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11 [Internet]. Lyon, France: International Agency for Research on Cancer; 2013. Available from:http://globocan.iarc.fr, accessed December 2013.
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There is no evidence for an association between uterine cancer incidence and deprivation in England.[1]  England-wide data for 2006-2010 show European age-standardised Open a glossary item incidence rates are similar for females living in the most deprived areas compared with the least deprived.[1]

Uterine Cancer (C54-C55), European Age-Standardised Incidence Rates by Deprivation Quintile, Females, England, 2006-2010

The estimated deprivation gradient in uterine cancer incidence between females living in the most and least deprived areas in England has not changed in the period 1996-2010.[1]

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Age-standardised rates Open a glossary item for White females with uterine (womb) cancer range from 16.9 to 17.7 per 100,000. Rates for Asian and Black females are similar ranging from 10.7 to 18.0 per 100,000 and 13.7 to 23.6 per 100,000 respectively.[1] There appears to be no significant variation in uterine (womb) cancer incidence by ethnicity in the UK.

Ranges are given because of the analysis methodology used to account for missing and unknown data. For uterine (womb) cancer, 27,680 cases were identified; 22% had no known ethnicity.

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In the UK around 38,700 women were still alive at the end of 2006, up to ten years after being diagnosed with uterine cancer.[1]

Uterine Cancer (C54-C55), One, Five and Ten Year Cancer Prevalence, UK, 31st December 2006

1 Year Prevalence 5 Year Prevalence 10 Year Prevalence
Female 5,920 23,364 38,667

Worldwide, it is estimated that there were nearly 1.10 million women still alive in 2008, up to five years after their diagnosis.[2]

References

  1. National Cancer Intelligence Network (NCIN). One, Five and Ten Year Cancer Prevalence by Cancer Network, UK, 2006. London: NCIN; 2010.
  2. Ferlay J, Shin HR, Bray F, et al. GLOBOCAN 2008 v1.2, Cancer Incidence and Mortality Worldwide. IARC CancerBase No.10 [Internet]. Lyon, France: International Agency for Research on Cancer. 2010. Available from http://globocan.iarc.fr. Accessed May 2011.
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