Uterine cancer incidence statistics

Cases

New cases of uterine cancer, 2014, UK

 

Proportion of all cases

Percentage uterine cancer is of total cancer cases, 2014, UK

 

Age

Peak rate of uterine cancer cases, 2012-2014, UK

 

Trend over time

Change in uterine cancer incidence rates since the early 1990s, UK

Uterine (womb) cancer is the fourth most common cancer in females in the UK (2014), accounting for 5% of all new cases of cancer in females.[1-4]

In 2014, there were 9,324 new cases of uterine cancer in the UK.[1-4] The crude incidence rate shows that there are 28 new uterine cancer cases for every 100,000 females in the UK.

The European age-standardised rate (AS rate) in England is significantly lower compared with Wales.[1-4] Rates do not differ significantly between the constituent countries of the UK.

Uterine Cancer (C54-C55), Number of New Cases, Crude and European Age-Standardised (AS) Incidence Rates per 100,000 Population, UK, 2014

England Wales Scotland Northern Ireland UK
Cases 7,702 549 843 230 9,324
Crude Rate 28.0 35.0 30.6 24.5 28.4
AS Rate 29.6 33.8 30.6 27.7 29.8
AS Rate - 95% LCL 28.9 30.9 28.5 24.1 29.2
AS Rate - 95% UCL 30.2 36.6 32.6 31.3 30.4

95% LCL and 95% UCL are the 95% lower and upper  confidence limits around the AS rate

For uterine cancer, like most cancer types, differences between countries largely reflect risk factor prevalence in years past.

References

  1. Data were provided by the Office for National Statistics on request, June 2016. Similar data can be found here: http://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/bulletins/cancerregistrationstatisticsengland/previousReleases.
  2. Data were provided by ISD Scotland on request, May 2016. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications/.
  3. Data were provided by the Welsh Cancer Intelligence and Surveillance Unit, Health Intelligence Division, Public Health Wales on request, June 2016. Similar data can be found here: http://www.wcisu.wales.nhs.uk.
  4. Data were provided by the Northern Ireland Cancer Registry on request, May 2016. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/.

About this data

Data is for: UK, 2014, ICD-10 C54-C55

Last reviewed:

Uterine cancer incidence is related to age, with the highest incidence rates overall being in females in their early 70s – a slightly different pattern to most cancers. In the UK in 2012-2014, on average each year almost 6 in 10 (58%) cases were diagnosed in females aged 65 and over.[1-4]

Age-specific incidence rates rise sharply from around age 40-44, peak in the 70-74 age group, and subsequently drop sharply.[1-4]

Uterine Cancer (C54-C55), Average Number of New Cases per Year and Age-Specific Incidence Rates per 100,000 Population, Females, UK, 2012-2014

For uterine cancer, like most cancer types, incidence increases with age. This largely reflects cell DNA damage accumulating over time. Damage can result from biological processes or from exposure to risk factors. A drop or plateau in incidence in the oldest age groups often indicates reduced diagnostic activity perhaps due to general ill health.

The age distribution of uterine cancer cases probably reflects hormonal changes during and after the menopause.

References

  1. Data were provided by the Office for National Statistics on request, June 2016. Similar data can be found here: http://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/bulletins/cancerregistrationstatisticsengland/previousReleases.
  2. Data were provided by ISD Scotland on request, May 2016. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications/.
  3. Data were provided by the Welsh Cancer Intelligence and Surveillance Unit, Health Intelligence Division, Public Health Wales on request, June 2016. Similar data can be found here: http://www.wcisu.wales.nhs.uk.
  4. Data were provided by the Northern Ireland Cancer Registry on request, May 2016. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/.

About this data

Data is for UK, 2012-2014, ICD-10 C54-C55

Last reviewed:

Uterine cancer age-standardised (AS) incidence rates have increased by 57% in females in the UK since the early 1990s.[1-3] Uterine cancer incidence rates increased by 3% in Great Britain between 1979-1981 and 1991-1993.[1-3]

Over the last decade in the UK (between 2003-2005 and 2012-2014), uterine cancer AS incidence rates in females have increased by 22%.[1-4]

Uterine Cancer (C54-C55), European Age-Standardised Incidence Rates, Females, UK, 1993-2014

Uterine cancer incidence rates have increased overall for all of the broad age groups in the UK since the early 1990s. The largest increase has been in females aged 70-79 with rates almost doubling by (89%) between 1993-1995 and 2012-2014.[1-3]

Uterine Cancer (C54-C55), European Age-Standardised Incidence Rates, Females, By Age, UK, 1993-2014​

For uterine cancer, like most cancer types, incidence trends largely reflect changing prevalence of risk factors and improvements in diagnosis and data recording. Recent incidence trends are influenced by risk factor prevalence in years past, and trends by age group reflect risk factor exposure in birth cohorts.

References

  1. Data were provided by the Office for National Statistics on request, June 2016. Similar data can be found here: http://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/bulletins/cancerregistrationstatisticsengland/previousReleases
  2. Data were provided by ISD Scotland on request, May 2016. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications/
  3. Data were provided by the Welsh Cancer Intelligence and Surveillance Unit, Health Intelligence Division, Public Health Wales on request, June 2016. Similar data can be found here: http://www.wcisu.wales.nhs.uk
  4. Data were provided by the Northern Ireland Cancer Registry on request, May 2016. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/

About this data

Data is for UK, 1993-2014, ICD-10 C54-C55

Last reviewed:

Overall stage at diagnosis

A high proportion (89-93%) of uterine cancer cases in England and Northern Ireland have stage at diagnosis recorded.[1,2]

Uterine cancer patients with a known stage are most commonly diagnosed at stage I (74-75%). More patients with a known stage are diagnosed at an early stage (81-83% are diagnosed at stage I or II), than a late stage (18-19% are diagnosed at stage III or IV). Between 7% and 8% of uterine cancer patients have metastases at diagnosis (stage IV).[1,2]

The stage distribution for each cancer type will reflect many factors including how the cancer type develops, the way symptoms appear, public awareness of symptoms, how quickly a person goes to see their doctor and how quickly the cancer is recognised and diagnosed by a doctor. It might also relate to whether a national screening programme that can detect early stage disease exists for that cancer type, along with the extent of uptake of that programme.

A cancer type associated with a large proportion of early stage diagnoses could be one that is more likely to be symptomatic at an earlier stage of development, with recognisable symptoms rather than more generic ones.

Uterine Cancer (C54-C55), Proportion of Cases Diagnosed at Each Stage, All Ages, England 2014, Northern Ireland 2010-2014

Data should not be compared between countries due to differences in time periods and possible differences in recording of stage at diagnosis.

Stage at diagnosis by deprivation

Late stage at diagnosis of uterine cancer is not associated with deprivation in England.[3]

Stage at diagnosis by age

Late stage at diagnosis of uterine cancer is more common in adults aged 80+ in England (26% diagnosed at stage III or IV), compared to those aged 60-79 (17% diagnosed at stage III or IV). And younger adults aged 15-59 (13% diagnosed at stage III or IV).[3]

Late stage uterine cancer is also more common in adults aged 60-79 in England (17% diagnosed at stage III or IV) compared to younger adults aged 15-59 (13% diagnosed at stage III or IV).[3]

These patterns by deprivation, age and sex are probably not explained  by other demographic differences.[4]

References

  1. National Cancer Intelligence Network. Stage Breakdown by CCG 2014. London: NCIN; 2016.
  2. Northern Ireland Cancer Registry, Queens University Belfast, Incidence by stage 2010-2014. Belfast: NICR; 2016.
  3. National Cancer Registration and Analysis Service. Routes to diagnosis of cancer by stage 2012-2013 workbook. London: NCRAS; 2016.
  4. Lyratzopoulos G, Abel G, Brown C, et al. Socio-demographic inequalities in stage of cancer diagnosis: evidence from patients with female breast, lung, colon, rectal, prostate, renal, bladder, melanoma, ovarian and endometrial cancer. Annals of Oncology, 2012:843-50.

About this data

Data is for: England 2014 ICD-10 C54, Northern Ireland 2010-2014, ICD-10 C54-C55 (overall stage at diagnosis) and England, 2012-2013, ICD-10 C54-C55 (stage at diagnosis by deprivation, age, sex, and ethnicity)

Data is not comparable between countries due to differences in time periods and possible differences in how countries record stage at diagnosis.

The proportions of patients diagnosed late only include cases with a known stage at diagnosis and are not adjusted for other demographics differences (e.g. age, sex, ethnicity) unless stated otherwise.

Last reviewed:

Most uterine cancer cases occur in the endometrium, with much smaller proportions in the myometrium, fundus uteri and isthmus uteri (2010-2012).[1-4]

A small proportion of cases did not have the specific part of the uterus recorded in cancer registry data, or overlapped more than one part.[1-4]

Cases and percentages may not sum due to rounding

References

  1. Data were provided by the Office for National Statistics on request, July 2014. Similar data can be found here: http://www.ons.gov.uk/ons/rel/vsob1/cancer-statistics-registrations--england--series-mb1-/index.html.
  2. Data were provided by ISD Scotland on request, April 2014. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications/index.asp.
  3. Data were provided by the Welsh Cancer Intelligence and Surveillance Unit on request, April 2014. Similar data can be found here: http://www.wales.nhs.uk/sites3/page.cfm?orgid=242&pid=59080.
  4. Data were provided by the Northern Ireland Cancer Registry on request, June 2014. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/CancerInformation/.
Last reviewed:

Uterine cancer incidence rates are projected to fall by 7% in the UK between 2014 and 2035, to 33 cases per 100,000 females by 2035.[1]

Uterine cancer (C54-C55), Observed and Projected Age-Standardised Incidence Rates, by Sex, UK, 1979-2035

 

It is projected that 11,576 cases of uterine cancer will be diagnosed in the UK in 2035.

References

  1. Smittenaar CR, Petersen KA, Stewart K, Moitt N. Cancer Incidence and Mortality Projections in the UK Until 2035. Brit J Cancer 2016.

About this data

Data is for: UK, 1979-2014 (observed), 2015-2035 (projected), ICD-10 C54-C55

Projections are based on observed incidence and mortality rates and therefore implicitly include changes in cancer risk factors, diagnosis and treatment. It is not possible to assess the statistical significance of changes between 2014 (observed) and 2035 (projected) figures. Confidence intervals are not calculated for the projected figures. Projections are by their nature uncertain because unexpected events in future could change the trend. It is not sensible to calculate a boundary of uncertainty around these already uncertain point estimates. Changes are described as 'increase' or 'decrease' if there is any difference between the point estimates.

More on projections methodology

Last reviewed:

The lifetime risk of developing uterine cancer is 1 in 41 for women, in 2012 in the UK.[1]

The lifetime risk for uterine cancer has been calculated on the assumption that the possibility of having more than one diagnosis of uterine cancer over the course of a lifetime is very low (‘Current Probability’ method).[2]

References

  1. Lifetime risk estimates calculated by the Statistical Information Team at Cancer Research UK. Based on data provided by the Office of National Statistics, ISD Scotland, the Welsh Cancer Intelligence and Surveillance Unit and the Northern Ireland Cancer Registry, on request, December 2013 to July 2014.
  2. Esteve J, Benhamou E and Raymond L. Descriptive epidemiology. IARC Scientific Publications No.128, Lyon, International Agency for Research on Cancer, pp 67-68 1994.
Last reviewed:

There is no evidence for an association between uterine cancer incidence and deprivation in England.[1]  England-wide data for 2006-2010 show European age-standardised incidence rates are similar for females living in the most deprived areas compared with the least deprived.[1]

Uterine Cancer (C54-C55), European Age-Standardised Incidence Rates by Deprivation Quintile, Females, England, 2006-2010

The estimated deprivation gradient in uterine cancer incidence between females living in the most and least deprived areas in England has not changed in the period 1996-2010.[1]

Last reviewed:

Age-standardised rates for White females with uterine (womb) cancer range from 16.9 to 17.7 per 100,000. Rates for Asian and Black females are similar ranging from 10.7 to 18.0 per 100,000 and 13.7 to 23.6 per 100,000 respectively.[1] There appears to be no significant variation in uterine (womb) cancer incidence by ethnicity in the UK.

Ranges are given because of the analysis methodology used to account for missing and unknown data. For uterine (womb) cancer, 27,680 cases were identified; 22% had no known ethnicity.

Last reviewed:

In the UK around 38,700 women were still alive at the end of 2006, up to ten years after being diagnosed with uterine cancer.[1]

Uterine Cancer (C54-C55), One, Five and Ten Year Cancer Prevalence, UK, 31st December 2006

1 Year Prevalence 5 Year Prevalence 10 Year Prevalence
Female 5,920 23,364 38,667

Worldwide, it is estimated that there were nearly 1.10 million women still alive in 2008, up to five years after their diagnosis.[2]

References

  1. National Cancer Intelligence Network (NCIN). One, Five and Ten Year Cancer Prevalence by Cancer Network, UK, 2006. London: NCIN; 2010.
  2. Ferlay J, Shin HR, Bray F, et al. GLOBOCAN 2008 v1.2, Cancer Incidence and Mortality Worldwide. IARC CancerBase No.10 [Internet]. Lyon, France: International Agency for Research on Cancer. 2010. Available from http://globocan.iarc.fr. Accessed May 2011.
Last reviewed:

Uterine cancer (C54 only) is the fourth most common cancer in Europe for females, and the tenth most common cancer overall, with around 99,000 new cases diagnosed in 2012 (6% of female cases and 3% of the total). In Europe (2012), the highest World age-standardised incidence rates for uterine cancer are in Macedonia; the lowest are in Greece. UK uterine cancer incidence rates are estimated to be the 20th highest in Europe.[1] These data are broadly in line with Europe-specific data available elsewhere.[2]

Uterine cancer (C54 only) is the sixth most common cancer worldwide for females, and the 14th most common cancer overall, with more than 319,000 new cases diagnosed in 2012 (5% of female cases and 2% of the total). Uterine cancer incidence rates are highest in Northern America, and lowest in South Central Asia, but this partly reflects varying data quality worldwide.[1]

Variation between countries may reflect different prevalence of risk factors, use of screening, and diagnostic methods.

References

  1. Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J, et al.Cancer incidence and mortality patterns in Europe: Estimates for 40 countries in 2012. European Journal of Cancer (2013) 49, 1374-1403.
  2. Ferlay J, Soerjomataram I, Ervik M, et al. GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11 [Internet]. Lyon, France: International Agency for Research on Cancer; 2013. Available from:http://globocan.iarc.fr, accessed December 2013.
Last reviewed:

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