Bone sarcoma incidence statistics

Cases

New cases of bone sarcoma, 2014, UK

 

Proportion of all cases

Percentage bone sarcoma is of total cancer cases, 2014, UK

 

Age

Peak rate of bone sarcoma cases, 2012-2014, UK

 

Trend since 1970s

Bone sarcoma incidence rates have been stable overall since the late 1970s, GB

 

Bone sarcoma accounts for less than 1% of all new cancer cases in the UK (2014). They account for less than 1% of the total in males, and less than 1% of the total in females.[1-4]

In 2014, there were 579 new cases of bone sarcoma in the UK: 305 (53%) in males and 274 (47%) in females, giving a male:female ratio of around 11:10.[1-4] The crude incidence rate Open a glossary item shows that there is 1 new case of bone sarcoma for every 100,000 males in the UK, and nearly 0.8 for every 100,000 females.

The European age-standardised incidence rates Open a glossary item (AS rates) do not differ significantly between the other constituent countries of the UK for either sex.[1-4]

Bone Sarcoma (C40-C41), Number of New Cases, Crude and European Age-Standardised (AS) Incidence Rates per 100,000 Population, Countries of the UK, 2014

England Wales Scotland Northern Ireland UK
Male Cases 250 16 34 5 305
Crude Rate 0.9 1.1 1.3 0.6 1.0
AS Rate 1.0 1.1 1.3 0.5 1.0
AS Rate - 95% LCL 0.8 0.6 0.9 0.1 0.9
AS Rate - 95% UCL 1.1 1.7 1.7 1.0 1.1
Female Cases 222 13 28 11 274
Crude Rate 0.8 0.8 1.0 1.2 0.8
AS Rate 0.8 0.8 1.0 1.2 0.8
AS Rate - 95% LCL 0.7 0.4 0.6 0.5 0.7
AS Rate - 95% UCL 0.9 1.2 1.4 1.8 0.9
Persons Cases 472 29 62 16 579
Crude Rate 0.9 0.9 1.2 0.9 0.9
AS Rate 0.9 0.9 1.1 0.9 0.9
AS Rate - 95% LCL 0.8 0.6 0.9 0.4 0.8
AS Rate - 95% UCL 1.0 1.3 1.4 1.3 1.0

95% LCL and 95% UCL are the 95% lower and upper confidence limits Open a glossary item around the AS Rate Open a glossary item

For bone sarcoma, like most cancer types, differences between countries largely reflect risk factor prevalence in years past.

References

  1. Data were provided by the Office for National Statistics on request, June 2016. Similar data can be found here: http://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/bulletins/cancerregistrationstatisticsengland/previousReleases.
  2. Data were provided by ISD Scotland on request, May 2016. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications/.
  3. Data were provided by the Welsh Cancer Intelligence and Surveillance Unit, Health Intelligence Division, Public Health Wales on request, June 2016. Similar data can be found here:  http://www.wcisu.wales.nhs.uk.
  4. Data were provided by the Northern Ireland Cancer Registry on request, May 2016. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/.

About this data

Data is for: UK, 2014, ICD-10 C40-C41

Last reviewed:

Bone sarcoma incidence is related to age, with the first peak in incidence rates being in older children and teenagers, and the second peak in older males and females. In the UK in 2012-2014, on average each year more than half (53%) of cases were diagnosed in people aged 45 and over.[1-4]

Age-specific incidence rates rise sharply from birth and peak first in older children and teenagers. Rates then drop gradually until around age 35-39 and remain stable until age 45-, before rising steadily again, with the highest rates overall in the 90+ age group for males and 85-89 age group for females. Incidence rates are significantly higher for males than females in those aged 40-44 and over and this gap is widest at the ages of 80 to 84, when the male:female ratio of age-specific incidence rates (to account for the different proportions of males to females in each age group) is around 18:10.[1-4]

Bone Sarcoma (C40-C41), Average Number of New Cases per Year and Age-Specific Incidence Rates Per 100,000 Population, UK, 2012-2014

For bone sarcoma, like most cancer types, incidence increases with age. This largely reflects cell DNA damage accumulating over time. Damage can result from biological processes or from exposure to risk factors. A drop or plateau in incidence in the oldest age groups often indicates reduced diagnostic activity perhaps due to general ill health.

References

  1. Data were provided by the Office for National Statistics on request, June 2016. Similar data can be found here: http://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/bulletins/cancerregistrationstatisticsengland/previousReleases.
  2. Data were provided by ISD Scotland on request, May 2016. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications/.
  3. Data were provided by the Welsh Cancer Intelligence and Surveillance Unit, Health Intelligence Division, Public Health Wales on request, June 2016. Similar data can be found here: http://www.wcisu.wales.nhs.uk.
  4. Data were provided by the Northern Ireland Cancer Registry on request, May 2016. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/.

About this data

Data is for UK, 2012-2014, ICD-10 C40-C41

Last reviewed:

Bone sarcoma incidence rates have remained stable in Great Britain since the late 1970s.[1-3] The trend is similar for males and females, and for both sexes there have been increases and decreases during this time.

For males, European age-standardised (AS) Open a glossary item  incidence rates remained stable overall between 1979-1981 and 2011-2013, though this includes a 15% decrease between 1979-1981 and 1992-1994, then a 19% increase between 1992-1994 and 2011-2013. For females, rates remained stable overall between 1979-1981 and 2011-2013, though this includes a 14% decrease between 1979-1981 and 1991-1993, then a 24% increase between 1991-1993 and 2011-2013.

Bone Sarcoma (C40-C41), European Age-Standardised Incidence Rates, By Sex, Great Britain, 1979-2013

ASR calculated with ESP2013. Not comparable with ASRs calculated with ESP1976.

Over the last decade in the UK (between 2002-2004 and 2011-2013), bone sarcoma AS incidence rates have remained stable, for males and females separately and for both sexes combined.[1-3,6]

Bone Sarcoma (C40-C41), European Age-Standardised Incidence Rates, By Sex, UK, 1993-2013

ASR calculated with ESP2013. Not comparable with ASRs calculated with ESP1976.

Bone sarcoma incidence trends probably reflect improvements in diagnostic techniques and data registration.[5,6]

Bone sarcoma incidence rates have remained relatively stable in most broad age groups in Great Britain since the late 1970s.[1-3] However, in people aged 25-49 and 50-59, European AS incidence rates increased by 53% and 39% respectively between 1979-1981 and 2011-2013. In the other age groups, rates have remained stable overall between 1979-1981 and 2011-2013, though in some there has been a significant decrease followed by an increase during this period.

Bone Sarcoma (C40-C41), European Age-Standardised Incidence Rates, by Age, Great Britain, 1979-2013

ASR calculated with ESP2013. Not comparable with ASRs calculated with ESP1976.

References

  1. Data were provided by the Office for National Statistics on request, July 2015. Similar data can be found here: http://www.ons.gov.uk/ons/rel/vsob1/cancer-statistics-registrations--england--series-mb1-/index.html.
  2. Data were provided by ISD Scotland on request, April 2015. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications/index.asp.
  3. Data were provided by the Welsh Cancer Intelligence and Surveillance Unit on request, February 2015. Similar data can be found here: http://www.wales.nhs.uk/sites3/page.cfm?orgid=242&pid=59080.
  4. Data were provided by the Northern Ireland Cancer Registry on request, June 2014. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/.
  5. National Cancer Intelligence Network. Bone Sarcoma Incidence and Survival: Tumours Diagnosed Between 1985 and 2009. London: NCIN; 2012.
  6. Whelan J, McTiernan A, Cooper N, et al. Incidence and survival of malignant bone sarcomas in England 1979-2007. Int J Cancer 2012;131(4):E508-17.
Last reviewed:

The largest proportion of bone sarcoma cases occur in the lower limb, with smaller proportions in the pelvic bones, and much smaller proportions in the upper limb and head (2010-2012).[1-4]

The proportion of cases in each part of the body is similar between males and females.[1-4]

A moderate proportion of cases did not have the specific location of the sarcoma recorded in cancer registry data, or overlapped more than one part.[1-4]

Cases and percentages may not sum due to rounding

References

  1. Data were provided by the Office for National Statistics on request, July 2014. Similar data can be found here:http://www.ons.gov.uk/ons/rel/vsob1/cancer-statistics-registrations--england--series-mb1-/index.html.
  2. Data were provided by ISD Scotland on request, April 2014. Similar data can be found here:http://www.isdscotland.org/Health-Topics/Cancer/Publications/index.asp.
  3. Data were provided by the Welsh Cancer Intelligence and Surveillance Unit on request, April 2014. Similar data can be found here:http://www.wales.nhs.uk/sites3/page.cfm?orgid=242&pid=59080.
  4. Data were provided by the Northern Ireland Cancer Registry on request, June 2014. Similar data can be found here:http://www.qub.ac.uk/research-centres/nicr/CancerInformation/.
Last reviewed:

Bone sarcoma incidence rates are projected to fall by 5% in the UK between 2014 and 2035, to 1 case per 100,000 people by 2035.[1] This includes an increase for females and a drop for males.

For males, bone sarcoma European age-standardised (AS) Open a glossary item incidence rates in the UK are projected to fall by 31% between 2014 and 2035, to 1 case per 100,000 by 2035.[1] For females, rates are projected to rise by 24% between 2014 and 2035, to 1 case per 100,000 by 2035.[1]

Bone sarcoma (C40-C41), Observed and Projected Age-Standardised Incidence Rates, by Sex, UK, 1979-2035

 

It is projected that 568 cases of bone sarcoma (217 in males, 351 in females) will be diagnosed in the UK in 2035.

References

  1. Smittenaar CR, Petersen KA, Stewart K, Moitt N. Cancer Incidence and Mortality Projections in the UK Until 2035. Brit J Cancer 2016.

About this data

Data is for: UK, 1979-2014 (observed), 2015-2035 (projected), ICD-10 C40-C41

Projections are based on observed incidence and mortality rates and therefore implicitly include changes in cancer risk factors, diagnosis and treatment. It is not possible to assess the statistical significance of changes between 2014 (observed) and 2035 (projected) figures. Confidence intervals are not calculated for the projected figures. Projections are by their nature uncertain because unexpected events in future could change the trend. It is not sensible to calculate a boundary of uncertainty around these already uncertain point estimates. Changes are described as"increase" or "decrease" if there is any difference between the point estimates.

More on projections methodology

Last reviewed:

The lifetime risk of developing bone sarcoma is around 1 in 1,140 for men and around 1 in 1,660 for women, in 2012 in the UK.[1]

The lifetime risk for bone sarcoma has been calculated on the assumption that the possibility of having more than one diagnosis of bone sarcoma over the course of a lifetime is very low (‘Current Probability’ method).[2]

References

  1. Lifetime risk estimates calculated by the Statistical Information Team at Cancer Research UK. Based on data provided by the Office of National Statistics, ISD Scotland, the Welsh Cancer Intelligence and Surveillance Unit and the Northern Ireland Cancer Registry, on request, December 2013 to July 2014.
  2. Esteve J, Benhamou E and Raymond L. Descriptive epidemiology. IARC Scientific Publications No.128, Lyon, International Agency for Research on Cancer, pp 67-68 1994.
Last reviewed:

There is no evidence for an association between bone sarcoma incidence and deprivation for either males or females in England.[1] England-wide data for 2006-2010 show European age standardised Open a glossary item incidence rates are similar for both males and females living in the most deprived areas compared with the least deprived.[1]

Bone Sarcoma (C40-C41), European Age-Standardised Incidence Rates by Deprivation Quintile, England, 2006-2010

The estimated deprivation gradient in bone sarcoma incidence between people living in the most and least deprived areas in England has not changed in the period 1996-2010.[1]

Last reviewed:

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