Decorative image

VIDE

Find out what VIDE is, how you have it and other important information about having VIDE.

VIDE is a combination of chemotherapy drugs made up of:

  • vincristine
  • ifosfamide
  • doxorubicin
  • etoposide

It is a treatment for a type of bone cancer called Ewing's sarcoma. 

How it works

These chemotherapy drugs destroy quickly dividing cells, such as cancer cells.

How you have it

Doxorubicin is a red fluid. All the other drugs are colourless fluids. You have the drugs into your bloodstream (intravenously). 

Drugs into your bloodstream

You have the treatment through a drip into your arm. A nurse puts a small tube (a cannula) into one of your veins and connects the drip to it.

You might need a central line. This is a long plastic tube that gives the drugs into a large vein, either in your chest or through a vein in your arm. It stays in while you’re having treatment, which may be for a few months.

When you have it

You usually have chemotherapy as cycles of treatment. You may have up to 6 cycles. Each cycle of treatment lasts 3 weeks.

So the whole course takes 18 weeks.

You have each cycle of treatment in the following way:

Day 1
  • You have vincristine as an injection into your bloodstream (intravenously) alongside a drip of salt water (saline).
  • You have doxorubicin as an injection into your bloodstream alongside a drip of salt water (saline).
  • You have etoposide as an injection into your bloodstream over 1 hour.
  • You have ifosfamide as an injection into your bloodstream over 3 hours.
  • You have a drug called mesna as a drip or as tablets – this is to stop the ifosfamide irritating your bladder and making it bleed.
Day 2
  • You have doxorubicin as an injection into your bloodstream alongside a drip of salt water (saline).
  • You have etoposide as an injection into your bloodstream over 1 hour.
  • You have ifosfamide as an injection into your bloodstream over 3 hours.
  • You have mesna as a drip or as tablets.
Day 3
  • You have doxorubicin as an injection into your bloodstream alongside a drip of salt water (saline).
  • You have etoposide as an injection into your bloodstream over 1 hour.
  • You have ifosfamide as an injection into your bloodstream over 3 hours.
  • You have mesna as a drip or as tablets.
Day 4 to day 21
  • You have no treatment.

You then start the next cycle of treatment.

After VIDE

After the course of VIDE you usually have surgery to remove the sarcoma.

Then you have more chemotherapy treatment, with either VAI or VAC combination chemotherapy.

Tests during treatment

You have blood tests before starting treatment and during your treatment. They check your levels of blood cells and other substances in the blood. They also check how well your liver and kidneys are working.

Side effects

Important information

Other medicines, foods and drink

Cancer drugs can interact with some other medicines and herbal products. Tell your doctor or pharmacist about any medicines you are taking. This includes vitamins, herbal supplements and over the counter remedies.

Pregnancy and contraception

This treatment might harm a baby developing in the womb. It is important not to become pregnant or father a child while you are having treatment and for a few months afterwards. Talk to your doctor or nurse about effective contraception before starting treatment.

Fertility

You may not be able to become pregnant or father a child after treatment with these drugs. Talk to your doctor before starting treatment if you think you may want to have a baby in the future. Men may be able to store sperm before starting treatment. Women may be able to store eggs or ovarian tissue but this is rare.

Breastfeeding

Don’t breastfeed during this treatment because the drugs may come through in your breast milk.

Treatment for other conditions

Always tell other doctors, nurses or dentists that you’re having this treatment if you need treatment for anything else, including teeth problems.

Immunisations

Don’t have immunisations with live vaccines while you’re having treatment and for at least 6 months afterwards.

In the UK, live vaccines include rubella, mumps, measles, BCG, yellow fever and Zostavax (shingles vaccine).

You can:

  • have other vaccines, but they might not give you as much protection as usual
  • have the flu vaccine
  • be in contact with other people who've had live vaccines as injections

Avoid contact with people who’ve had live vaccines taken by mouth (oral vaccines). This includes the rotavirus vaccine given to babies. The virus is in the baby’s urine for up to 2 weeks and can make you ill. So, you mustn't change their nappies for 2 weeks after their vaccination.

You also need to avoid anyone who has had oral polio or typhoid vaccination recently.

More information about this treatment

For further information about this treatment go to the electronic Medicines Compendium (eMC) website.

You can report any side effect you have to the Medicines Health and Regulatory Authority (MHRA) as part of their Yellow Card Scheme.

Last reviewed: 
27 Apr 2015
  • Electronic Medicines Compendium 
    Accessed April 2015

  • Handbook of Cancer Chemotherapy (8th edition)
    Roland K Keel
    Lippincott Williams and Wilkins, 2012

  • Immunisation against infectious disease: Chapter 6: General contraindications to vaccination
    Public Health England
    First published: March 2013 and regularly updated on the Gov.UK website

  • Network Chemotherapy Protocols (Sarcoma)

    Thames Valley Cancer Network, May 2014

Information and help

Dangoor sponsorship

About Cancer generously supported by Dangoor Education since 2010.