Chemotherapy uses anti cancer (cytotoxic) drugs to destroy cancer cells. Find out about chemotherapy for advanced stomach cancer.
Advanced stomach cancer is a cancer that began in the stomach and has spread to another part of the body.
Chemotherapy for advanced stomach cancer can relieve the symptoms. It can also control the cancer and improve your quality of life for a time. But it can’t cure the disease.
The drugs circulate throughout the body in the bloodstream. They can reach the cancer cells wherever they are in the body.
Your doctor will make a plan for your treatment. How often you have treatment depends on this plan. Your doctor might change what chemotherapy you have depending on your side effects.
Usually you have a combination of 2 or 3 drugs, the most common types are:
- cisplatin and capecitabine (XP)
- epirubicin, cisplatin and capecitabine (ECX)
- epirubicin,cisplatin,fluorouracil (ECF)
- epirubicin, oxaliplatin and capecitabine (EOX)
- epirubicin, carboplatin, capecitabine (ECarboX)
- paclitaxal and carboplatin
Other drugs you may have include:
For advanced stomach cancer with HER2 protein, you may have:
- trastuzumab (Herceptin) and XP (cisplatin and capecitabine)
- trastuzumab (Herceptin) and cisplatin and 5-FU
Trastuzumab is a type of biological therapy. These treatments interfere with the way cells work. They can boost the body's immune system to help fight off or destroy cancer cells, or they can block signals telling cells to grow.
You have most of these drugs into your bloodstream through a drip into your arm. A nurse puts a small tube into one of your veins and connects the drip to it.
Or you might need a central line. This is a long plastic tube that gives the drugs into a large vein, either in your chest or through a vein in your arm. It stays in while you’re having treatment, which may be for a few months.
You have capecitabine and Lonsurf as tablets.
Whether you have a full or empty stomach can affect how much of a drug gets into your bloodstream.
You should take the right dose, no more, no less. Never stop taking a cancer drug without talking to your specialist first.
You usually have treatment into your bloodstream at the cancer day clinic. You might sit in a chair for a few hours so it’s a good idea to take newspapers, books or electronic devices to help to pass the time. You can usually bring a friend or family member with you.
You have some types of chemotherapy over several days. You might be able to have some drugs through a small portable pump that you take home.
For some types of chemotherapy you have to stay in a hospital ward. This could be overnight or for a couple of days.
Clare Disney (nurse): Hello, my name is Clare and this is a cancer day unit.
So when you arrive and you’ve reported into with the receptionist, one of the nurses will call you through when your treatment is ready, sit you down and go through all the treatment with you.
Morning, Iris. My name is Clare. I am the nurse who is going to be looking after you today. We’re going to start by putting a cannula in the back of your hand and giving you some anti sickness medication. And then I am going to come back to you and talk through the chemotherapy with you and the possible side effects you may experience throughout your treatment. Is that okay?
Before you have each treatment you’ll need to have a blood test to check your bloods are okay. And you’ll also be reviewed by one of the doctors to make sure you’re fit and well for your treatment. Sometimes you’ll have the blood test taken on the day of your treatment; other times you’ll have it the day before your treatment when you see the doctor.
Each chemotherapy is made up for each individual patient, depending on the type of cancer they have and where it is and depending their height, weight and blood results.
So, depending on where your cancer is some people have their chemotherapy drug, their cancer drug by drip, some will have an injection and other people will have tablets.
So, Iris, your chemotherapy is going to be given to you in what we call cycles and the cycles are given every three weeks for a period of six cycles. So, you will be coming in for approximately five months for your chemotherapy.
Depending on where your cancer is and what type of cancer you have will be dependent on how often you come in for treatment. An example of a treatment cycle would be for you to come in on Day 1, Day 8 and Day 15 then to have a week’s break before you come back again for Day 1 treatment.
Depending on the type of treatment that you are having we will also give you some anti sickness tablets to take alongside your chemotherapy and also some drugs to prevent any reactions if that’s appropriate.
All chemotherapy is given over different time periods so it’s best to check with your nurse about how long you are likely to be in the unit for. This can range from anything up to an hour to an all day treatment slot so please be prepared to bring along some bits to keep you occupied books and music.
So, before you go home it’s important to make sure you have got the tablets you need to go home with your anti sickness medications and any other symptom control tablets that you may require. Also, to make sure that you’ve got the telephone numbers for the oncology unit to phone if you have a temperature or you are experiencing any other symptoms at home that you need to ask advice about.
So, please make sure when you leave the unit that you’ve got all the information you require and if you’ve got any questions at all don’t hesitate to ask the nurse who will be able to answer them for you.
Before your next cycle of treatment you will come in and see the doctor in the clinic room, you’ll have a blood test and an examination to make sure you are fit and well for treatment you will then come back the following day or later on that week for treatment.
When you have it
You usually have chemotherapy every 3 weeks. Each 3 week period is called a cycle. You may have between 3 and 6 cycles of chemotherapy.
You need to have blood tests to make sure it’s safe to start your treatment. You have these either a few days before or on the day your treatment begins. You have blood tests before each round or cycle of treatment.
Side effectsCommon chemotherapy side effects include:
- feeling sick
- loss of appetite
- losing weight
- feeling very tired
- a lower resistance to infection
- bleeding and bruising easily
- which drug you have
- how much of each drug you have
- how you react
Most side effects only last for the few days that you’re having the drugs. The team caring for you can help reduce your side effects.
Between 2 and 8 out of 100 people (2 to 8%) have low levels of an enzyme called DPD in their bodies. A lack of DPD can mean you’re more likely to have severe side effects from capecitabine or fluorouracil. It might take you a bit longer to recover from the chemotherapy. These side effects can rarely be life threatening.
Low DPD levels don’t cause symptoms so you won’t know if you have a deficiency. Talk to your doctor if you are worried and about whether you need to have a test to check for it.
Some people have severe side effects from capecitabine or fluorouracil even if they don't have low DPD levels. Contact your doctor or nurse if your side effects are severe.
When you go home
Chemotherapy for advanced stomach cancer can be difficult to cope with. Tell your doctor or nurse about any problems or side effects you have. The nurse will give you telephone numbers to call if you have any problems at home.