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Photodynamic therapy

Photodynamic therapy (PDT) is also called light activating treatment. It kills cancer cells by using a combination of a light sensitising drug and a very bright light.

PDT can completely cure some early food pipe (oesophageal) cancers. But sometimes you need other treatments too, such as surgery or chemotherapy.

PDT can shrink advanced cancers that are blocking the food pipe. Then you can swallow more easily.

You have the treatment in hospital in the endoscopy department or x-ray department. It usually takes about 30 minutes.

What is photodynamic therapy (PDT)?

Photodynamic therapy (PDT) is also called:

  • photoradiation therapy
  • phototherapy
  • photochemotherapy

PDT combines a drug that makes cells sensitive to light with exposure to a particular type of light. The drug is called a photosensitiser or photosensitising agent.

There are different types of sensitising drugs and each is activated by light of a specific wavelength. The type of photosensitiser and light wavelength you have depends on where the cancer is in your body.

How PDT works

When the sensitising drugs are exposed to their particular light, they produce a type of oxygen that kills nearby cells.

PDT directly kills cancer cells, but doctors think it also acts in other ways to shrink or destroy tumours. The sensitising drug may damage blood vessels in the tumour, and stop it from receiving nutrients that it needs. PDT may also trigger the immune system to attack the cancer cells.

Before your treatment

Your doctor or specialist nurse explains what happens and how they do the treatment. They ask you to sign a consent form saying that you agree to have the procedure. You can ask them any questions that you have. Tell them about any medicines you are taking.

You have a medicine that makes cells sensitive to light and then you go home. You might have the medicine as a liquid that you swallow or you might have it as an injection through a small tube in a vein in the back of your hand.

The light sensitising drug circulates throughout your body. So your skin and eyes become sensitive to light. You need to avoid bright sunlight and bright indoor light.

When you go outside, you must cover all your skin and wear sunglasses.

Two to three days later, you go to the endoscopy department at the hospital.

Having treatment

You shouldn’t eat or drink anything except water for 4 to 6 hours before the treatment. You can drink water until 2 hours beforehand.

A nurse puts a small tube called a cannula into a vein in the back of your hand. They go with you to the endoscopy or x-ray department.

The doctor or nurse injects medicine to make you sleepy into the cannula. Or you might have a general anaesthetic.

When you’re very sleepy or asleep your doctor gently puts a long flexible tube called an endoscope into your food pipe. The tube has a small camera on the end so they can see the cancer. They position the end of the tube close to the tumour and shine a low power laser light at it.

Diagram showing photodynamic therapy for oesophageal cancer

The light activates the drug in the cancer cells.  

Your doctor takes the endoscopy tube out.

After treatment

You stay in the endoscopy department or x-ray department until the sedation or anaesthetic wears off. You might wear an oxygen mask for a short time. A nurse then takes you back to your ward. You can usually go home that evening.

Side effects

Sensitivity to light

The sensitivity to light can last for 6 weeks or more.

Avoid bright sunlight and bright indoor light. And cover all your skin and wear sunglasses if you go outside.

Your skin can get red, blistered or swollen if you’re exposed to bright light. Tell your nurse or doctor straight away if this happens.

Eating and drinking

You can’t eat or drink for the first 4 to 6 hours after treatment. Your nurse tells you when you can start drinking. Then you build up to eating soft foods or normal foods again. A dietitian can advise you on what to eat.

Soreness and pain

You might have a sore throat. Taking painkillers for a few days helps.

Tell your nurse or doctor if you still have pain.

Feeling sick

Let your nurse or doctor know if you feel sick. They can give you medicines to reduce sickness.

Bleeding

You might have some slight bleeding in the food pipe. It might give you a metallic taste in your mouth. This usually gets better over a few days.

Your nurse will give you mouthwashes. Tell them if you cough up blood.

A hole in the food pipe

Damage to the food pipe can tear it or make a hole (perforation). This is very rare. 

In the first 3 days after having treatment, tell your doctor or nurse straight away if you

  • have difficulty breathing
  • get severe chest pain
  • vomit blood
  • can’t keep food or drinks down

Removing the dead cells

A few days after the treatment your doctor might need to remove the dead cells. They do this using an endoscopy tube.

If the cancer cells come back

If the cancer cells grow again, you can have photodynamic therapy again, or your doctor might suggest other treatments.

Last reviewed: 
31 Oct 2019
  • Guidelines for the management of oesophageal and gastric cancer. British Society of Gastroenterology (BSG), 2011.

  • Oesophageal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
    F. Lordick and others
    Ann Oncol. 2016 27 Suppl 6: v50-v57

  • Oesophageal cancer
    J Lagergren and others
    The Lancet Vol 390, November 25th 2017

  • Palliative photodynamic therapy for advanced oesophageal cancer
    National Institute of Health and Care Excellence (NICE), 2007

  • PHOTOFRIN® (porfimer sodium) INJECTION prescribing information. 
    Accessed October 2019

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