Oral cancer incidence statistics

Cases

New cases of oral cancer, 2013, UK

 

Proportion of all cases

Percentage oral cancer is of total cancer cases, 2013, UK

 

Age

Age that almost half of oral cancer cases are diagnosed, 2011-2013, UK

 

Trend since 1970s

Oral cancer incidence rates have increased since the late 1970s, GB

 

Oral cancer is the 14th most common cancer in the UK (2013), accounting for 2% of all new cases. In males, it is the 11th most common cancer (3% of all male cases), whilst it is the 16th most common cancer in females (1% of all new cases).[1-4]

In 2013, there were 7,591 new cases of oral cancer in the UK: 5,103 (67%) in males and 2,488 (33%) in females, giving a male:female ratio of around 21:10.[1-4] The crude incidence rate Open a glossary item shows that there are 16 new oral cancer cases for every 100,000 males in the UK, and 8 for every 100,000 females.

The European age-standardised incidence rates Open a glossary item (AS rates) for both sexes are significantly higher in Scotland compared with England and Northern Ireland).[1-4] For males, AS rates in England are also significantly lower than in Wales. The rates do not differ significantly between the other UK countries.[1-4]

Oral Cancer (C00-C06, C09-C10, C12-C14), Number of New Cases, Crude and European Age-Standardised (AS) Incidence Rates per 100,000 Population, UK, 2013

England Wales Scotland Northern Ireland UK
Male Cases 4,098 298 574 133 5,103
Crude Rate 15.4 19.7 22.2 14.8 16.2
AS Rate 17.4 20.4 23.8 18.6 18.2
AS Rate - 95% LCL 16.9 18.1 21.8 15.5 17.7
AS Rate - 95% UCL 18.0 22.7 25.7 21.8 18.7
Female Cases 2,014 135 285 54 2,488
Crude Rate 7.4 8.6 10.4 5.8 7.6
AS Rate 7.7 8.4 10.4 6.4 8.0
AS Rate - 95% LCL 7.4 7.0 9.2 4.7 7.7
AS Rate - 95% UCL 8.1 9.8 11.6 8.1 8.3
Persons Cases 6,112 433 859 187 7,591
Crude Rate 11.3 14.0 16.1 10.2 11.8
AS Rate 12.4 14.1 16.8 11.9 12.9
AS Rate - 95% LCL 12.1 12.8 15.6 10.2 12.6
AS Rate - 95% UCL 12.7 15.5 17.9 13.7 13.2

95% LCL and 95% UCL are the 95% lower and upper confidence limits Open a glossary item around the AS rate Open a glossary item

ASR calculated with ESP2013. Not comparable with ASRs calculated with ESP1976.

Oral cavity cancer (ICD-10 C02-C04, C06) incidence rates within England are highest in the north, largely reflecting variation in prevalence of oral cancer risk factors.[6]

References

  1. Data were provided by the Office for National Statistics on request, July 2015. Similar data can be found here: http://www.ons.gov.uk/ons/rel/vsob1/cancer-statistics-registrations--england--series-mb1-/index.html
  2. Data were provided by ISD Scotland on request, April 2015 Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications/index.asp
  3. Data were provided by the Welsh Cancer Intelligence and Surveillance Unit on request, February 2015. Similar data can be found here: http://www.wales.nhs.uk/sites3/page.cfm?orgid=242&pid=59080.
  4. Data were provided by the Northern Ireland Cancer Registry on request, March 2015. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/.
  5. National Cancer Intelligence Unit Head and Neck Cancer Profiles Accessed August 2013.
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Oral cancer incidence is strongly related to age, though the patterns by age are different for males and females. In the UK in 2011-2013, on average each year almost half (45%) of cases were diagnosed in people aged 65 and over.[1-4]

For males, age-specific incidence rates rise sharply from around age 40-44, peak in the 60-64 age group, and subsequently drop until rising again from ages 80-84 to 90+. For females, age-specific incidence rates rise gradually from around age 40-44, with the highest rates in the 90+ age group. Incidence rates are higher for males than for females aged 35-39 and over and this gap is widest at the ages of 45-49, when the male:female ratio of age-specific incidence rates (to account for the different proportions of males to females in each age group) is around 28:10.[1-4]

Oral Cancer (C00-C06, C09- C10, C12-C14), Average Number of New Cases per Year and Age-Specific Incidence Rates, UK, 2011-2013

References

  1. Data were provided by the Office for National Statistics on request, July 2015. Similar data can be found here: http://www.ons.gov.uk/ons/rel/vsob1/cancer-statistics-registrations--england--series-mb1-/index.html
  2. Data were provided by ISD Scotland on request, April 2015. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications/index.asp
  3. Data were provided by the Welsh Cancer Intelligence and Surveillance Unit on request, February 2015. Similar data can be found here: http://www.wales.nhs.uk/sites3/page.cfm?orgid=242&pid=59080.
  4. Data were provided by the Northern Ireland Cancer Registry on request, March 2015. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/.
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Oral cancer incidence rates have increased by 92% in Great Britain since the late 1970s.[1-3] This includes a larger overall increase for females than for males.

For males, European age-standardised Open a glossary item (AS) incidence rates increased by 73% between 1979-1981 and 2011-2013. The rise is larger for females, with rates having increased by 88% between 1979-1981 and 2011-2013.

Oral Cancer (C00-C06, C09-C10, C12-C14), European Age-Standardised Incidence Rates, Great Britain, 1979-2013

ASR calculated with ESP2013. Not comparable with ASRs calculated with ESP1976.

Over the last decade in the UK (between 2002-2004 and 2011-2013), oral cancer AS incidence rates have increased by 39% for males and females combined, with a similar increase in males and females (37% in both).[1-4]

Oral Cancer (C00-C06, C09-C10, C12-C14), European Age-Standardised Incidence Rates, UK, 1993-2013

ASR calculated with ESP2013. Not comparable with ASRs calculated with ESP1976.

Oral cancer incidence trends probably reflect changing prevalence of risk factors, with recent incidence trends influenced by risk factor prevalence in years past.

Oral cancer incidence rates have increased overall for most broad age groups (except males aged 80+) in Great Britain since the late 1970s.[1-3] In males, the largest increases have been in those aged 25-49 and 50-59, with European AS incidence rates almost tripling (180% and 187% increases, respectively) between 1979-1981 and 2011-2013. In males aged 80 and over, rates decreased by 39% between 1979-1981 and 2007-2009, and have since increased by 13%.[1-3]

Oral Cancer (C00-C06, C09-C10, C12-C14), European Age-Standardised Incidence Rates, Males, By Age, Great Britain, 1979-2013

ASR calculated with ESP2013. Not comparable with ASRs calculated with ESP1976.

In males, the largest increases have been in those aged 25-49 and 50-59, with European AS incidence rates almost tripling (180% and 187% increases, respectively) between 1979-1981 and 2011-2013. In males aged 80 and over, rates decreased by 39% between 1979-1981 and 2007-2009, and have since increased by 13%.[1-3]

Oral Cancer (C00-C06, C09-C10, C12-C14), European Age-Standardised Incidence Rates, Females, By Age, Great Britain, 1979-2013

ASR calculated with ESP2013. Not comparable with ASRs calculated with ESP1976.

References

  1. Data were provided by the Office for National Statistics on request, July 2015. Similar data can be found here: http://www.ons.gov.uk/ons/rel/vsob1/cancer-statistics-registrations--england--series-mb1-/index.html
  2. Data were provided by ISD Scotland on request, April 2015. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications/index.asp
  3. Data were provided by the Welsh Cancer Intelligence and Surveillance Unit on request, February 2015. Similar data can be found here: http://www.wales.nhs.uk/sites3/page.cfm?orgid=242&pid=59080.
  4. Data were provided by the Northern Ireland Cancer Registry on request, March 2015. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/
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The lifetime risk of developing oral cancer is 1 in 75 for men and around 1 in 150 for women, in 2012 in the UK.[1]

The lifetime risk for oral cancer has been calculated to account for the possibility that someone can have more than one diagnosis of oral cancer over the course of their lifetime (‘Adjusted for Multiple Primaries’ (AMP) method).[2]

References

  1. Lifetime risk estimates calculated by the Statistical Information Team at Cancer Research UK. Based on data provided by the Office of National Statistics, ISD Scotland, the Welsh Cancer Intelligence and Surveillance Unit and the Northern Ireland Cancer Registry, on request, December 2013 to July 2014.
  2. Sasieni PD, Shelton J, Ormiston-Smith N, et al. What is the lifetime risk of developing cancer?: The effect of adjusting for multiple primaries. Br J Cancer, 2011. 105(3): p. 460-5.
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In males, the largest proportion of oral cancer cases occur in the tonsils, with smaller proportions in the base of the tongue, floor of the mouth and palate (2010-2012).[1-4]

In females, the largest proportion of oral cancer cases occurs in the tonsils, with slightly smaller proportions in the palate, gum, floor of the mouth and base of the tongue (2010-2012).[1-4]

The proportions of cases in the tonsils, base of the tongue and piriform sinus are higher in males (20.0%, 12.5% and 6.1%, respectively) than females (14.0%, 7.4% and 2.7%, respectively). In the gum, the proportion is higher in females (7.7%) than males (4.2%), and there are no marked sex differences in the other sites of oral cancer.[1-4]

A large proportion of cases did not have the specific site recorded in cancer registry data, or overlapped more than one part.[1-4]

Oral Cancer (C00-C06, C09-C10, C12-C14), Percentage Distribution of Cases Diagnosed By Anatomical Site, by Sex, UK, 2010-2012

Cases and percentages may not sum due to rounding

References

  1. Data were provided by the Office for National Statistics on request, July 2014. Similar data can be found here: http://www.ons.gov.uk/ons/rel/vsob1/cancer-statistics-registrations--england--series-mb1-/index.html.
  2. Data were provided by ISD Scotland on request, April 2014. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications/index.asp.
  3. Data were provided by the Welsh Cancer Intelligence and Surveillance Unit on request, April 2014. Similar data can be found here: http://www.wales.nhs.uk/sites3/page.cfm?orgid=242&pid=59080.
  4. Data were provided by the Northern Ireland Cancer Registry on request, June 2014. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/CancerInformation/.
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Lip and oral cavity cancer (C00-C08) is the 15th most common cancer in Europe, with around 61,400 new cases diagnosed in 2012 (2% of the total). Around 34,100 cases of other pharyngeal cancer (C09-C10 and C12-C14) were diagnosed in Europe in 2012, accounting for 1% of total cancer cases. In Europe (2012), the highest World age-standardised Open a glossary item incidence rates for lip and oral cavity cancer are in Hungary for both men and women; the lowest rates are in Greece for men and Cyprus for women. UK lip and oral cavity cancer incidence rates are estimated to be the 16th lowest in males in Europe, and 11th highest in females. Incidence rates for other pharyngeal cancer are highest in Hungary for both men and women; the lowest rates are in Cyprus for both men and women. UK other pharyngeal cancer incidence rates are estimated to be the 15th lowest in males in Europe, and 13th highest in females.[1] These data are broadly in line with Europe-specific data available elsewhere.[2]

Lip and oral cavity cancer (C00-C08) is the 15th most common cancer worldwide, with more than 300,000 new cases diagnosed in 2012 (2% of the total). More than 142,000 cases of other pharyngeal cancer (C09-C10 and C12-C14) were diagnosed worldwide in 2012, accounting for 1% of total cancer cases. Lip and oral cavity cancer incidence rates are highest in Melanesia and lowest in Western Africa, but this partly reflects varying data quality worldwide. Incidence rates of other pharyngeal cancer are highest in Western Europe and lowest in Western Africa.[1]

Variation between countries may reflect different prevalence of risk factors, use of screening, and diagnostic methods.

References

  1. Ferlay J, Soerjomataram I, Ervik M, et al. GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11 [Internet]. Lyon, France: International Agency for Research on Cancer; 2013. Available from: http://globocan.iarc.fr, accessed December 2013.
  2. Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J, et al.Cancer incidence and mortality patterns in Europe: Estimates for 40 countries in 2012. European Journal of Cancer (2013) 49, 1374-1403.
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Incidence by deprivation is provided for oral cavity cancer (C02-C04 and C06) and oropharyngeal cancer (C01 and C09-C10) separately.

There is evidence for an association between oral cavity cancer incidence and deprivation in England.[1] The association is strong for males, and significantly weaker for females. European age-standardised Open a glossary item incidence rates are 135% higher for males living in the most deprived areas in England compared with the least deprived, and 45% higher for females, as shown for people diagnosed with oral cavity cancer during 2006-2010.[1]

Oral Cavity Cancer (C02-C04 and C06), European Age-Standardised Incidence Rates by Deprivation Quintile, England, 2006-2010

The estimated deprivation gradient in oral cavity cancer incidence for males and females living in the most and least deprived areas in England has not changed in the period 1996-2010.[1] It is estimated that there would have been around 420 fewer cancer cases each year in England during 2006-2010 if all people experienced the same incidence rates as the least deprived.[1]

There is also an association between oropharyngeal cancer incidence and deprivation in England.[1] European age-standardised  incidence rates are 81% higher for males living in the most deprived areas in England compared with the least deprived, and 94% higher for females, as shown for people diagnosed with oropharyngeal cancer during 2006-2010.[1]

Oropharyngeal Cancer (C01 and C09-C10), European Age-Standardised Incidence Rates by Deprivation Quintile, England, 2006-2010

The estimated deprivation gradient in oropharyngeal cancer incidence between people living in the most and least deprived areas in England has widened for females in the period 1996-2010, but has not changed for males.[1] There would have been around 330 fewer oropharyngeal cancer cases each year in England during 2006-2010 if all people experienced the same incidence rates as the least deprived.[1]

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Age-standardised Open a glossary item rates for White males with oral cancer (ICD-10 C00-C08 only) range from 6.6 to 7.0 per 100,000. Rates for Asian males are similar, ranging from 4.1 to 7.1 per 100,000, whereas the rates for Black males are significantly lower, ranging from 2.8 to 5.7 per 100,000. For females there is a different pattern - the age-standardised rates for White females range from 3.4 to 3.6 per 100,000. Rates for Asian females are significantly higher, ranging from 4.0 to 7.1 per 100,000, whereas the rates for Black females are significantly lower, ranging from 1.2 to 2.9 per 100,000.[1]

Ranges are given because of the analysis methodology used to account for missing and unknown data. For mouth cancer, 14,963 cases were identified; 19% had no known ethnicity.

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In the UK more than 38,600 people were still alive at the end of 2006, up to ten years after being diagnosed with head and neck cancer (includes the lip, oral cavity, pharynx, nasal cavity, middle ear, sinuses and larynx, ICD-10 codes C00-C14, C30-C32).[1

Head and Neck Cancer (C00-C14, C30-32), One, Five and Ten Year Cancer Prevalence, UK, 31st December 2006

1 Year Prevalence 5 Year Prevalence 10 Year Prevalence
Male 4,833 17,008 26,619
Female 2,088 7,521 12,039
Persons 6,921 24,529 38,658

Worldwide, it is estimated that almost 900,000 cancer patients of the lip, oral cavity and pharynx excluding the nasopharynx (C00-C08, C09-C10,C12-14) were still alive in 2008, up to five years after their diagnosis.[2]

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Cancer Statistics Explained

See information and explanations on terminology used for statistics and reporting of cancer, and the methods used to calculate some of our statistics.

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