Research into diagnosing breast cancer
This page tells you about research into finding better ways of diagnosing breast cancer. You can find information about
- A quick guide to what's on this page
- Diagnosing breast cancer
- Breast screening in younger women
- Extra tests during breast cancer screening
- The immune system and breast cancer screening
- Screening breast ducts
Research into diagnosing breast cancer
All tests for cancer must be fully researched before they can be adopted as standard. This is so that we can be sure they work better than approaches we already use. It also helps to make sure that they are safe and don’t have harmful effects.
A lot of research is looking into finding better ways of diagnosing breast cancer. Trials and studies are checking new blood tests, different types of mammograms, and scans.
Cancer Research UK supports a lot of UK laboratory research into cancer and also supports many UK and international clinical trials.
You can view and print the quick guides for all the pages in the Treating breast cancer section.
There is a lot of research into diagnosing breast cancer. Cancer Research UK supports a lot of UK and international clinical trials. You can find detailed information about breast cancer trials on our clinical trials database.
The UK breast cancer screening programme plays a big part in picking up cancers early. The screening service includes women between the ages of 50 and 70 in the UK. This is being expanded from 47 to 73 years. If you are between these ages, you automatically receive an invitation to go for breast screening every 3 years. Research is looking at newer and more accurate tests for picking up breast cancer in women with no symptoms (screening) and in women who have suspicious symptoms.
Usually women don’t enter the UK breast screening programme until the age of 47. But women with a strong family history of breast cancer may start having mammograms earlier and more often.
The FH-01 trial looked into yearly screening for women between 40 and 49 who were thought to be at high risk of breast cancer. It found that the yearly mammograms found cancers at an earlier stage and helped to save lives.
The FH-02 trial is looking at whether yearly mammograms can help save the lives of women aged 35 to 39 who are at an increased risk of breast cancer. The trial has closed and we are waiting for the results.
Studies are looking at measuring each woman's risk of breast cancer and whether extra tests are helpful in breast screening.
Finding each woman's risk of breast cancer
The PROCAS study is collecting information from women taking part in the NHS breast screening programme in Greater Manchester. The chance of getting breast cancer is not the same for all women. Some have a higher risk and some have a much lower risk.
As well as having mammograms, women taking part also answer questions about their family history and give a sample of spit (saliva). Researchers in this study hope to be able to accurately work out each woman’s risk of breast cancer. Then in the future each woman could be given appropriate advice on how to reduce their risk. Women at higher risk could perhaps be offered screening more often.
Some women who are screened for breast cancer using breast X-rays (mammograms) are called back for further tests. This can be very worrying, but most of them will turn out not to have cancer.
Doctors are trying to develop a new blood test to use in breast screening so that fewer women are called back unnecessarily. Some studies are checking for particular proteins or other substances in the blood of women called back after abnormalities are found on their mammogram.
You can find details of trials looking at breast cancer detection on our clinical trials database.
Doctors want to find out whether there are changes in the immune system in women with early breast cancer. If there are immune system reactions that could be picked up somehow, they may help doctors find breast cancer at an earlier stage.
There is a research study looking for antibodies and white blood cells called T cells in women with or without breast cancer. Antibodies and white blood cells are part of the immune system. The main aim of this study is to find new signs (markers) in the blood of women with breast cancer. The markers could one day be tested to help doctors screen for and diagnose breast cancer. The trial has closed and we are waiting for the results.
You can find out more about the immune system.
This is called intraductal screening. It is a new way of picking up breast cancer. Tests being researched include
This is called nipple aspiration. The nipple aspiration test gets samples of breast fluid from the milk ducts. The fluid in the tubes of the breast (the ducts) is in direct contact with the cells lining the breast ducts and lobules. This lining is a common area for breast cancer to develop. The doctor or nurse takes fluid from the nipple using a similar pump to the one used to express milk when breast feeding.
Doctors call this intraductal lavage. The doctor puts some anaesthetic on your nipple and then puts a very thin tube into one of the milk ducts of the breast. They put some saline (salt water) fluid into the tube and then take it out again with a syringe. The fluid washes around the duct and contains some of the cells that line the ducts.
Doctors call this duct endoscopy. The doctor puts some anaesthetic cream on your nipple and then puts a very fine flexible tube with a light and magnifying lens into a breast duct. The doctor can look at the cells and also take samples of fluid.
Trials are looking into how reliable these types of intraductal screening might be in picking up DCIS or breast cancer or whether it could help to decide a woman's risk of developing breast cancer in the future.
These trials are listed on our clinical trials database.
Most mammograms in the NHS breast screening programme are checked by two specialists. It is more accurate if there are two professional opinions instead of one. But there is a great deal of strain on the system and this will increase as the age range of women taking part increases from 47 to 73.
Researchers have looked at using a computerised reader system called computer aided detection (CAD). The CADET 2 trial used CAD and one specialist to read mammograms for more than 28,000 women. It found that it is as accurate as using two specialists.
Now the NHS breast screening programme is looking at how CAD can be used as part of the screening programme in the UK.
Doctors call this digital breast tomosynthesis or 3D mammography. It is a new way of taking X-rays. A scanner produces a series of X-rays at different angles over a 30 degree arc. From these, a computer creates a 3D image of the breast. This gives more information about the breast tissue and a clearer picture.
Some UK hospitals are trying 3D mammograms. The aim of the TOMMY trial is to compare the accuracy of 3D and standard mammograms when diagnosing breast changes found during screening. The trial has closed and we are waiting for the results.
A study in Dundee is also comparing digital breast tomosynthesis with standard mammograms in women under 60.
One study is for screening young women with a high risk of breast cancer. Researchers want to see if 3D mammograms can reduce the need for other tests to confirm (or rule out) a diagnosis of cancer. We have information about the tomosynthesis for screening young women trial.
Thermography is also called digital infrared imaging. Some people call it a thermal scan. The 3 parts to the theory behind it are that
- The area around a cancer is warmer than the surrounding breast tissue
- Cancer cells are more active than normal cells and produce more heat
- Hotter areas can be seen on a scanner showing differences in temperature
In 2012, researchers pulled together all the research that has been done on heat scans. This is called a systematic review. They found that there is not enough evidence to show that thermography is reliable enough as a screening test for breast cancer. There is not enough evidence that it can help to diagnose breast cancer when used with mammograms in screening. And there is not enough evidence that it can help to diagnose breast cancer when there are signs that a breast cancer might be there.
Until we have research evidence to show it is reliable, thermography is not recommended as a screening test or to try and diagnose breast cancer.
Researchers are using various types of scans to try to improve the detection and monitoring of breast cancer. They include
Magnetic resonance imaging (MRI) is a way of diagnosing cancer using magnetic waves to produce a picture.
The COMICE trial added MRI to the standard breast cancer diagnosis tests – mammogram, biopsy and breast ultrasound. The researchers wanted to see whether adding MRI could show the size of the tumour more accurately. They hoped that it would reduce the number of women who need further operations after their surgery.
The researchers found that adding MRI did not reduce the number of women needing further operations. So, they recommended that MRI is not added to routine diagnostic testing for women with invasive ductal breast cancer. But MRI can often accurately show the size of the cancer for women with invasive lobular cancer. So it is usually used for these women when planning surgery. It is also helpful if women have had breast implants.
Fusion scans combine MRI and ultrasound. Researchers are looking at whether they may be able to show areas of breast cancer more clearly than MRI on its own. These scans are only used as part of research trials.
With a PEM scan you first have an injection of a very small amount of a radioactive drug (tracer). The amount of radiation is very small – no more than you have during a normal X-ray. It only stays in the body for a few hours. The drug is taken up by cancer cells but also areas of inflammation. Doctors think that it may be very helpful in finding areas of ductal carcinoma in situ (DCIS).
Scientists are investigating a new test which uses light to find cancer cells in breast tissue. This is done either during a biopsy, or on breast tissue removed when you have surgery. The test is called elastic scattering spectroscopy (ESS). Doctors hope that they will be able to use this test directly on the breast to diagnose cancer much quicker.
This is a new type of breast lump biopsy being researched. Doctors call it image guided radiofrequency biopsy. It aims to take a biopsy of an abnormal area of the breast through a small cut. Doctors carry it out under local anaesthetic. Using X-ray or ultrasound guidance they put a small probe close to the abnormal area. The probe cuts using radio waves and removes the tissue. A small cage attached to the probe holds the tissue. This way of doing a biopsy aims to cause less bleeding and swelling than a normal biopsy.
In August 2009 the National Institute for Health and Care Excellence (NICE) recommended that there is not currently enough evidence about the safety of this procedure and they are concerned that it may not always show a cancer when one is present.
NICE recommends that this procedure should only be used to remove cancer that has been diagnosed using other tests and there are no other surgical options. They also ask for more research to be carried out into image guided radiofrequency biopsy of breast lumps.
Rated 5 out of 5 based on 3 votes
Question about cancer? Contact our information nurse team