EOF | Cancer Research UK
Cancer Research UK on Google+ Cancer Research UK on Facebook Cancer Research UK on Twitter

What EOF is

EOF is the name of a combination of chemotherapy drugs. It is made up of

  • E – Epirubicin
  • O – Oxaliplatin
  • F – Fluorouracil (5FU)

The links above take you to more information about the individual side effects of each drug.

EOF is a treatment for 

  • Stomach cancer
  • Cancer of the junction between the stomach and the food pipe (gastro oesphageal cancer) 

How you have EOF

You usually have EOF chemotherapy as cycles of treatment. Each cycle of treatment lasts 3 weeks. Depending on your needs, you may have up to 6 cycles, taking 4 to 5 months in total.

You have EOF drugs into your bloodstream (intravenously). You may have them through a central line, a portacath or a PICC line. These are long, plastic tubes that give the drugs directly into a large vein in your chest. You have the tube put in just before your course of treatment starts and it stays in place as long as you need it.

You have each cycle of treatment in the following way.

On the first day you have epirubicin as an injection into your central line or PICC line. Epirubicin is a red liquid. You then have oxaliplatin as a drip (an infusion) over a couple of hours. 

You have the fluorouracil (5FU) non stop into your central line all the way through your treatment. You have a small portable pump which gives a continuous low dose of fluorouracil. You can go home with the pump and need to go back to the hospital every week to have it replaced or refilled.

Your next cycle of treatment then starts 3 weeks later when you have the epirubicin and oxaliplatin again.

The side effects associated with EOF are listed below. You can use the underlined links to find out more about each one. For general information, see our side effects of cancer drugs section.


Common side effects

More than 10 in every 100 people have one or more of the side effects listed below.

  • An increased risk of getting an infection from a drop in white blood cells – it is harder to fight infections and you can become very ill. You may have headaches, aching muscles, a cough, a sore throat, pain passing urine, or you may feel cold and shivery. If you have a severe infection this can be life threatening. Contact your treatment centre straight away if you have any of these effects or if your temperature goes above 38°C. You will have regular blood tests to check your blood cell levels
  • Tiredness and breathlessness due to a drop in red blood cells (anaemia) – you may need a blood transfusion
  • Bruising more easily due to a drop in platelets – you may have nosebleeds or bleeding gums after brushing your teeth. Or you may have lots of tiny red spots or bruises on your arms or legs (known as petechia)
  • Epirubicin can turn your urine pink or red for about a day after treatment – this won't harm you
  • Numbness or tingling in fingers and toes can cause difficulty with fiddly things such as doing up buttons. This starts within a few days or weeks. It usually goes within a few months of finishing treatment
  • Tiredness and weakness (fatigue) during and after treatment – most people find their energy levels are back to normal within 6 months to a year
  • Diarrhoea occurs in about 2 out of 3 people (60%) – drink plenty of fluids such as water and fruit squashes and tell your doctor or nurse immediately if diarrhoea becomes severe or continues for more than 3 days
  • Feeling or being sick can be severe with epirubicin and oxaliplatin. It is usually well controlled with anti sickness medicines. If your sickness is not controlled tell your doctor or nurse. They can change your anti sickness medicines to others that work better for you
  • Some people develop soreness, redness and peeling on the palms of the hands and soles of the feet (palmar – plantar syndrome). This may cause tingling, numbness, pain and dryness
  • A sore mouth
  • Women may stop having periods (amenorrhoea) but this may be temporary
  • Loss of fertility – you may not be able to become pregnant or father a child after treatment with this drug. Talk to your doctor before starting treatment if you think you may want to have a baby in the future. Men may be able to store sperm before starting treatment
  • Hair loss – you may have complete hair loss but the hair will grow back once the treatment ends
  • Loss of taste or a metallic taste in your mouth
  • Skin changes including rashes (which may be itchy) and darker skin
  • Sensitivity of the skin to sunlight and redness or soreness in areas previously treated with radiotherapy

Occasional side effects

Between 1 and 10 in every 100 people have one or more of these.

  • Difficulty swallowing or breathing can be triggered by cold air in the first 5 days after you have oxaliplatin. This usually clears up on its own. Tell your doctor or nurse if you have this side effect. Avoid cold drinks or ice cubes for the first few days
  • Inflammation around the drip site – if you notice any signs of redness, swelling or leaking at your drip site, tell your chemotherapy nurse straight away
  • Sore eyes – your doctor or nurse can give you eye drops to help
  • Blurred vision
  • Watery eyes from increased production of tears
  • Loss of appetite
  • You may have ringing in the ears (tinnitus) which nearly always gets better on its own
  • Some people have an allergic reaction while having EOF treatment, usually during the first or second treatment. Let your treatment team know straight away if you have any skin rashes, itching, dizziness, headaches, or shivering. Also tell them if you have shortness of breath, anxiety, or if you feel hot, go red in the face, or have a sudden need to pass urine

Rare side effects

Fewer than 1 in 100 people have these.

  • Swelling of hands and feet due to fluid build up
  • Confusion or unsteadiness
  • Damage to heart muscle from epirubicin, which is usually temporary. For a small number of people may be permanent. Your doctor will check your heart before and after your treatment

Important points to remember

You won't get all these side effects. Any that you have may be mild. A side effect may get worse through your course of treatment. Or you may have more side effects as the course goes on. This depends on

  • How many times you've had a drug before
  • Your general health
  • How much of the drug you have (the dose)
  • Other drugs you are having

Coping with side effects

Talk to your doctor, pharmacist or nurse about all your side effects so they can help you manage them. They can give you advice or reassure you. Your nurse will give you a contact number to ring if you have any questions or problems. If in doubt, call them.

Other medicines

Tell your doctor about any other medicines you are taking, including vitamins, herbal supplements and over the counter remedies. Some drugs can react together.

Pregnancy and contraception

These drugs may harm a baby developing in the womb. It is important not to become pregnant or father a child while you are having treatment and for a few months afterwards. Talk to your doctor or nurse about effective contraception before starting treatment.


Do not breastfeed during this treatment because the drugs may come through in the breast milk.


Immunisations and chemotherapy

You should not have immunisations with live vaccines while you are having chemotherapy or for at least 6 months afterwards. In the UK, these include rubella, mumps, measles (usually given together as MMR), BCG, yellow fever and Zostavax (shingles vaccine).

You can have other vaccines, but they may not give you as much protection as usual until your immune system has fully recovered from your chemotherapy. It is safe to have the flu vaccine.

It is safe for you to be in contact with other people who've had live vaccines as injections. There can be problems with vaccines you take by mouth (oral vaccines), but not many people in the UK have these now. So there is usually no problem in being with any baby or child who has recently had any vaccination in the UK. You might need to make sure that you aren't in contact with anyone who has had oral polio, cholera or typhoid vaccination recently, particularly if you live abroad.


Related information


More information about EOF

This page does not list all the very rare side effects of this treatment that are very unlikely to affect you. For further information look at the Electronic Medicines Compendium website at www.medicines.org.uk.

If you have a side effect not mentioned here that you think may be due to this treatment you can report it to the Medicines Health and Regulatory Authority (MHRA) at yellowcard.mhra.gov.uk.

Rate this page:
Submit rating
Rate this page
Rate this page for no comments box
Please enter feedback to continue submitting
Send feedback
Question about cancer? Contact our information nurse team

No Error

Updated: 27 November 2014