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Imatinib (Glivec)

Find out what imatinib is, how you have it and other important information about taking imatinib.

Imatinib is a targeted cancer drug (biological therapy) and is also known by its brand name Glivec (pronounced glee-vec).

It is a treatment for many different types of cancer. 

How it works

Imatinib is a type of biological therapy called a tyrosine kinase inhibitor (TKI). Tyrosine kinases are proteins that cells use to signal to each other to grow. They act as chemical messengers. There are a number of different tyrosine kinases and blocking them stops the cancer cells growing. 

Imatinib targets different tyrosine kinases, depending on the type of cancer.

How you have it

You have imatinib as a tablet that you swallow whole, with a glass of water after food. If you can’t swallow the tablets, you can dissolve them in a glass of mineral water or apple juice. Drop the whole tablets into the fluid, and stir with a spoon until the tablets have broken up completely. Then drink the whole glassful.

Taking your tablets

You must take tablets according to the instructions your doctor or pharmacist gives you.

Speak to your pharmacist if you have problems swallowing the tablets.

Whether you have a full or an empty stomach can affect how much of a drug gets into your bloodstream.

You should take the right dose; no more, no less.

Never stop taking a cancer drug without talking to your specialist first.

When you have it

You have imatinib either once or twice a day, depending on the condition you have. You usually continue taking imatinib for as long as it works, unless the side effects get too bad.

For acute lymphoblastic leukaemia that is Philadelphia chromosome positive, you may have imatinib on its own, or with chemotherapy.

Tests during treatment

You have blood tests before starting treatment and during your treatment. They check your levels of blood cells and other substances in the blood. They also check how well your liver and kidneys are working.

Side effects

Important information

Other medicines, foods and drink

Cancer drugs can interact with some other medicines and herbal products. Tell your doctor or pharmacist about any medicines you are taking. This includes vitamins, herbal supplements and over the counter remedies.

Pregnancy and contraception

This treatment might harm a baby developing in the womb. It is important not to become pregnant or father a child while you are having treatment and for a few months afterwards. Talk to your doctor or nurse about effective contraception before starting treatment.

Fertility

You may not be able to become pregnant or father a child after treatment with this drug. Talk to your doctor before starting treatment if you think you may want to have a baby in the future. Men may be able to store sperm before starting treatment. Women may be able to store eggs or ovarian tissue but this is rare.

Breastfeeding

Don’t breastfeed during this treatment because the drug may come through in your breast milk.

Treatment for other conditions

Always tell other doctors, nurses or dentists that you’re having this treatment if you need treatment for anything else, including teeth problems.

Immunisations

Don’t have immunisations with live vaccines while you’re having treatment and for at least 6 months afterwards.

In the UK, live vaccines include rubella, mumps, measles, BCG, yellow fever and Zostavax (shingles vaccine).

You can:

  • have other vaccines, but they might not give you as much protection as usual
  • have the flu vaccine
  • be in contact with other people who've had live vaccines as injections

Avoid contact with people who’ve had live vaccines taken by mouth (oral vaccines). This includes the rotavirus vaccine given to babies. The virus is in the baby’s urine for up to 2 weeks and can make you ill. So, you mustn't change their nappies for 2 weeks after their vaccination.

You also need to avoid anyone who has had oral polio or typhoid vaccination recently.

Children and adolescents

Some children and adolescents taking imatinib may have slower than normal growth. The treatment team will monitor this carefully.

More information about this treatment

For further information about this treatment go to the electronic Medicines Compendium (eMC) website.

You can report any side effect you have to the Medicines Health and Regulatory Authority (MHRA) as part of their Yellow Card Scheme.

Information and help

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