Find out what bevacizumab is, how you have it and other important information about having bevacizumab.
Bevacizumab is a cancer treatment drug and is also known by its brand name, Avastin.
It is a treatment for many different types of cancers.
How it works
Bevacizumab targets a cancer cell protein called vascular endothelial growth factor (VEGF). This protein helps cancers to grow blood vessels, so they can get food and oxygen from the blood. All cancers need a blood supply to be able to survive and grow.
Bevacizumab blocks this protein and stops the cancer from growing blood vessels, so it is starved and can't grow. Treatments that interfere with the development of a blood supply are called anti angiogenesis treatments.
How you have it
You have bevacizumab (Avastin) as a drip into your bloodstream.
Drugs into your bloodstream
You have the treatment through a drip into your arm. A nurse puts a small tube (a cannula) into one of your veins and connects the drip to it.
You might need a central line. This is a long plastic tube that gives the drugs into a large vein, either in your chest or through a vein in your arm. It stays in while you’re having treatment, which may be for a few months.
When you have it
You have the first dose of bevacizumab over 90 minutes. If you don't have any problems, you have the second dose over 60 minutes. The third dose takes 30 minutes. Every dose after that will take 30 minutes.
You usually have bevacizumab (Avastin) every 2 to 3 weeks. Treatment usually continues for as long as it controls your cancer.
Tests during treatment
You have blood tests before starting treatment and during your treatment. They check your levels of blood cells and other substances in the blood. They also check how well your liver and kidneys are working.
Other medicines, foods and drink
Cancer drugs can interact with some other medicines and herbal products. Tell your doctor or pharmacist about any medicines you are taking. This includes vitamins, herbal supplements and over the counter remedies.
Pregnancy and contraception
This drug may harm a baby developing in the womb. It is important not to become pregnant while you are having treatment and for a few months afterwards. Talk to your doctor or nurse about effective contraception before starting treatment.
Loss of fertility
You may not be able to become pregnant or father a child after treatment with this drug. Talk to your doctor before starting treatment if you think you may want to have a baby in the future. Men may be able to store sperm before starting treatment. Women may be able to store eggs or ovarian tissue but this is rare.
Breastfeeding is not advisable during treatment and for 6 months afterwards. The drug may come through in the breast milk.
Treatment for other conditions
Always tell other doctors, nurses or dentists that you’re having this treatment if you need treatment for anything else, including teeth problems.
Don’t have immunisations with live vaccines while you’re having treatment and for at least 6 months afterwards.
In the UK, live vaccines include rubella, mumps, measles, BCG, yellow fever and shingles vaccine (Zostavax).
- have other vaccines, but they might not give you as much protection as usual
- have the flu vaccine
- be in contact with other people who've had live vaccines as injections
Avoid contact with people who’ve had live vaccines taken by mouth (oral vaccines). This includes the rotavirus vaccine given to babies. The virus is in the baby’s urine for up to 2 weeks and can make you ill. So, avoid changing their nappies for 2 weeks after their vaccination if possible. Or wear disposable gloves and wash your hands well afterwards.
You also need to avoid anyone who has had oral polio or typhoid vaccination recently.
Slow wound healing
Bevacizumab (Avastin) can make wounds heal more slowly. You won't have bevacizumab until at least 28 days after surgery or until any wounds have completely healed.
More information about this treatment
For further information about this treatment go to the electronic Medicines Compendium (eMC) website.
You can report any side effect you have to the Medicines Health and Regulatory Authority (MHRA) as part of their Yellow Card Scheme.