This page tells you about the chemotherapy drug combination called FEC-T and its possible side effects. There is information about
FEC-T is the name of a combination of chemotherapy drugs used to treat breast cancer. It is made up of the drugs
- F – Fluorouracil (5FU)
- E – Epirubicin
- C – Cyclophosphamide
- T – Docetaxel (Taxotere)
The chemotherapy drugs in the FEC-T combination destroy quickly dividing cells such as cancer cells.
You have FEC-T drugs into your bloodstream (intravenously). You can have them through a thin, short tube (a cannula) put into a vein in your arm each time you have treatment. Or you may have them through a central line, a portacath, or a PICC line. These are long, plastic tubes that give the drugs directly into a large vein in your chest. You have the tube put in before or during your course of treatment and it stays in place as long as you need it.
You can read our information about having chemotherapy into a vein.
You have FEC-T chemotherapy as cycles of treatment. You may have up to 8 cycles. Each cycle of treatment lasts 3 weeks.
For the first 3 or 4 cycles you have 3 drugs (fluorouracil, epirubicin and cyclophosphamide), which is the FEC part of the treatment. The drugs are given as slow injections into your cannula or central line on the first day of each treatment cycle. It takes about half an hour to give all 3 drugs. Then you have no more treatment for almost 3 weeks (20 days).
For the next 3 or 4 cycles you have docetaxel (taxotere) as a 1 hour drip (infusion) on the first day of each cycle. Then you have no treatment for almost 3 weeks (20 days).
You have blood tests before starting treatment and regularly during your treatment. The tests check your levels of blood cells and other substances in the blood. They also check how well your liver and kidneys are working.
We've listed the side effects associated with FEC-T. You can use the links to find out more about each side effect. Where there is no link, please go to our information about cancer drug side effects or use the search box at the top of the page.
You may have a few side effects. They may be mild or more severe. A side effect may get better or worse through your course of treatment. Or more side effects may develop as the course goes on. This depends on
- How many times you've had the drug before
- Your general health
- The amount of the drug you have (the dose)
The side effects may be different if you are having FEC-T with other medicines.
Tell your doctor or nurse straight away if any of the side effects get severe.
More than 10 in every 100 people have one or more of the side effects listed below.
- An increased risk of getting an infection from a drop in white blood cells – it is harder to fight infections and you can become very ill. You may have headaches, aching muscles, a cough, a sore throat, pain passing urine, or you may feel cold and shivery. If you have a severe infection this can be life threatening. Contact your treatment centre straight away if you have any of these effects or if your temperature goes above 38°C
- Tiredness and breathlessness due to a drop in red blood cells (anaemia) – you may need a blood transfusion
- Bruising more easily due to a drop in platelets – you may have nosebleeds, or bleeding gums after brushing your teeth. Or you may have lots of tiny red spots or bruises on your arms or legs (known as petechiae)
- Tiredness and weakness (fatigue) during and after treatment – most people find their energy levels are back to normal within 6 months to a year
- Complete head and body hair loss occurs in almost everyone treated with FEC. It usually begins 2 to 5 weeks after the treatment starts but your hair will grow back once the treatment ends
- Feeling or being sick can be quite severe but anti sickness injections or tablets usually control it. It usually starts a few hours after each treatment and lasts for about a day. Tell your doctor or nurse if it is not controlled as you can try other anti sickness medicines that may work better for you.
- Loss of appetite
- Diarrhoea – make sure you drink plenty of fluids and if diarrhoea becomes severe or lasts more than 3 days, tell your doctor or nurse. They can give medicines to help
- A metallic taste or loss of taste may happen on the days you have treatment. It should get better when the treatment ends
- A sore mouth or mouth ulcers
- Fluid build up occurs in about 5 out of 10 people (50%). You may have swelling of the hands and feet, breathlessness and weight gain. Steroids can help to prevent this
- A skin rash which may itch affects about 5 out of 10 people (50%)
- Some people develop soreness, redness and peeling on the palms of the hands and soles of the feet (hand-foot syndrome). This may cause tingling, numbness, pain and dryness
- Your fingernails may change colour
- Up to 1 in 4 people (25%) have an allergic reaction while having docetaxel treatment, usually the first or second time. Some people have a reaction to epirubicin. Let your treatment team know straight away if you have any skin rashes, headaches, itching, or feel hot or shivery. Also tell them if you go red in the face, feel dizzy, breathless or anxious, or have a sudden need to pass urine
- Red, sore eyes – they may feel as if they have grit in them and you may have blurred vision or watery eyes. Your doctor or nurse can prescribe eye drops to help
- Your periods may stop during the treatment but this may only be temporary
- Loss of fertility – you may not be able to become pregnant after this treatment. Talk to your doctor before starting treatment if you think you may want to have a baby in the future
- Your urine may become a pink or red colour the day after having epirubicin – this won't harm you
Between 1 and 10 in every 100 people have one or more of these.
- Skin changes – your skin may darken or be very sensitive to sunlight. Use a high factor sun cream and cover up when you go out
- Brown markings on the skin following the line of the vein where fluorouracil has been injected
- Nail changes – your nails may become ridged, darken or get brittle and chip or break easily
- Liver or kidney changes – these won't cause symptoms and will go back to normal once the treatment ends
- Inflammation around the drip site – if you notice any signs of redness, swelling or leaking at your drip site, tell your nurse straight away
- Burning, stinging or pain on passing urine (cystitis) – if you see blood in your urine contact your doctor or nurse straight away
- Damage to heart muscle, which may make your heartbeat irregular – this usually temporary but for a small number of people may be permanent. Your doctor will check your heart before and after your treatment
- Aching muscles and joints
- A high temperature (fever)
Fewer than 1 in 100 people have these.
- Confusion or unsteadiness
- Long term changes in lung tissue can cause a cough or breathlessness
- There is a small risk of developing another cancer in the future after FEC-T treatment. If this is going to happen, it most often occurs 5 to 8 years after treatment
Talk to your doctor, pharmacist or nurse about all your side effects so they can help you manage them. They can give you advice or reassure you. Your nurse will give you a contact number to ring if you have any questions or problems. If in doubt, call them.
Tell your doctor about any other medicines you are taking, including vitamins, herbal supplements and over the counter remedies. Some drugs can react together.
Pregnancy and contraception
This drug may harm a baby developing in the womb. It is important not to become pregnant while you are having treatment and for a few months afterwards. Talk to your doctor or nurse about effective contraception before starting treatment.
Don't breastfeed during this treatment because the drug may come through in the breast milk.
You should not have immunisations with live vaccines while you are having chemotherapy or for at least 6 months afterwards. In the UK, these include rubella, mumps, measles (usually given together as MMR), BCG, yellow fever and Zostavax (shingles vaccine).
You can have other vaccines, but they may not give you as much protection as usual until your immune system has fully recovered from your chemotherapy. It is safe to have the flu vaccine.
It is safe for you to be in contact with other people who've had live vaccines as injections. There can be problems with vaccines you take by mouth (oral vaccines), but not many people in the UK have these now. So there is usually no problem in being with any baby or child who has recently had any vaccination in the UK. You might need to make sure that you aren't in contact with anyone who has had oral polio, cholera or typhoid vaccination recently, particularly if you live abroad.
This page does not list all the very rare side effects of this treatment that are very unlikely to affect you. For further information about these drugs look at the Electronic Medicines Compendium website at www.medicines.org.uk.
If you have a side effect not mentioned here that you think may be due to this treatment you can report it to the Medicines Health and Regulatory Authority (MHRA) at
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