Types and grades of stomach cancer

Adenocarcinoma

Adenocarcinomas are cancers that develop in gland cells. These cells make mucus and stomach juices.

This is the most common type of stomach cancer in the UK.

Linitis plastica

Linitis plastica is a rare type of adenocarcinoma. 

Linitis plastica spreads to the muscles of the stomach wall and makes it thicker and more rigid. This means that the stomach can’t hold as much and doesn’t stretch or move as it should when you’re digesting food. This stiff walled stomach is sometimes called a leather bottle stomach.

This type of cancer is very fast growing and is often at an advanced stage at diagnosis. This means that surgery isn't usually possible. It might be difficult to completely remove a large cancer or one that has spread beyond the stomach wall. 

The main treatments for linitis plastica are surgery, chemotherapy or targeted drugs depending on the stage of your cancer. You might also have radiotherapy to help relieve your symptoms. 

Find out more about the treatment for stomach cancer

Rare types of stomach cancer

The information in our stomach cancer section is about the staging and treatment of adenocarcinoma.

Treatment and staging for rare types of stomach cancer depends on what type of cell the cancer starts in. 

Squamous cell cancer

These cancers develop in squamous cells. These are the flat cells covering the lining of the stomach. Squamous cell cancer is treated in the same way as adenocarcinoma.

Non-Hodgkin lymphoma

Non-Hodgkin lymphoma is a cancer of the lymphatic system. The treatment is different to other stomach cancers. 

Read about non-Hodgkin lymphoma

Gastrointestinal stromal tumour (GIST)

This is a rare type of sarcoma found in the digestive system, most often in the wall of the stomach.

Read about GISTs

Neuroendocrine cancers

Stomach neuroendocrine cancers develop in the neuroendocrine cells of the stomach. They are rare. You might also hear them called stomach neuroendocrine neoplasms (NENs).

Read more about stomach neuroendocrine cancer

Grades of stomach cancer

The grade means how abnormal the cells look under a microscope. Knowing the grade gives your doctor an idea of how the cancer might behave and what treatment you need.

The grades of cancer cells are from 1 to 3:

• grade 1 (low grade) look like normal stomach cells

• grade 2 look a bit like normal cells

• grade 3 (high grade) look very abnormal and not like normal cells

Differentiation

As normal cells grow and mature, they become specialised for their role and place in the body. This is called differentiation. 

This means that your grade of cancer may be described as:

• well differentiated

• moderately differentiated

• poorly differentiated

Cancer cells can look very like normal cells. When they are you might hear your doctor describe them as well differentiated or low grade. These cancers are more likely to grow slowly.

If the cancer cells look underdeveloped and nothing like a normal cell, they are known as poorly differentiated or high grade. These cancers tend to grow and spread more quickly than low grade cancers.

Find out about stages of stomach cancer