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Vandetanib (Caprelsa)

Find out what vandetanib is, how you have it and other important information about taking vandetanib.

Vandetanib (also called by the brand name Caprelsa) is a treatment for advanced medullary thyroid cancer.

You might have it as part of a clinical trial for other types of thyroid cancer. It is also being looked at in trials for other types of cancer.

How it works

Vandetanib is a type of biological therapy called a cancer growth blocker. It stops signals (chemical messengers) that cancer cells use to divide and grow. 

How you have it

You take vandetanib as tablets, you swallow them whole with water. 

You have vandetanib once a day. You can choose the best time to take it. But you should take it at about the same time every day. It can be with or without food.  

Dissolving vandetanib

You can dissolve the tablets in still water if you find it difficult to swallow. Drop the tablet into half a glass of water without crushing it (don't use any other type of liquid).

Stir until it has dissolved, this may take 10 to 15 minutes. Then drink the liquid straight away. Refill the glass halfway with water and drink it to make sure you have had all the medicine. 

When you forget to take vandetanib 

Take it straight away if less than 12 hours have passed. Do not take the tablets if it has been more than 12 hours. Take your next tablets at the usual time the next day. 

Taking your tablets or capsules

You must take tablets and capsules according to the instructions your doctor or pharmacist gives you.

You should take the right dose, not more or less.

Never stop taking a cancer drug without talking to your specialist first.

When you have it

You usually carry on taking vandetanib for as long as it works. 

Tests during treatment

You have blood tests before starting treatment and during your treatment. They check your levels of blood cells and other substances in the blood. They also check how well your liver and kidneys are working.

Side effects

Important information

Other medicines, foods and drink

Cancer drugs can interact with some other medicines and herbal products. Tell your doctor or pharmacist about any medicines you are taking. This includes vitamins, herbal supplements and over the counter remedies.

Pregnancy and contraception

This drug may harm a baby developing in the womb. It is important not to become pregnant or father a child while you are having treatment with this drug and for at least 4 months afterwards. Talk to your doctor or nurse about effective contraception before starting treatment.

Breastfeeding

Don’t breastfeed during this treatment because the drug may come through in your breast milk.

Treatment for other conditions

Always tell other doctors, nurses or dentists that you’re having this treatment if you need treatment for anything else, including teeth problems.

Immunisations

Don’t have immunisations with live vaccines while you’re having treatment and for at least 6 months afterwards.

In the UK, live vaccines include rubella, mumps, measles, BCG, yellow fever and Zostavax (shingles vaccine).

You can:

  • have other vaccines, but they might not give you as much protection as usual
  • have the flu vaccine
  • be in contact with other people who've had live vaccines as injections

Avoid contact with people who’ve had live vaccines taken by mouth (oral vaccines). This includes the rotavirus vaccine given to babies. The virus is in the baby’s urine for up to 2 weeks and can make you ill. So, you mustn't change their nappies for 2 weeks after their vaccination.

You also need to avoid anyone who has had oral polio or typhoid vaccination recently.

More information about this treatment

For further information about this treatment go to the electronic Medicines Compendium (eMC) website.

You can report any side effect you have to the Medicines Health and Regulatory Authority (MHRA) as part of their Yellow Card Scheme.

Information and help

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