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Leuprorelin (Prostap, Lutrate)

Find out what leuprorelin is, how you have it and other important information about taking leuprorelin for prostate cancer. It is also called Prostap or Lutrate.

How it works

Leuprorelin is a type of hormone therapy known as a LHRH (luteinising hormone-releasing hormone) agonist. It lowers the level of testosterone made by the testicles. Prostate cancer depends on testosterone to grow. So leuprorelin can shrink cancer or slow its growth. 

How you have it

You have leuprorelin as an injection either:

  • into a muscle in your leg or buttocks
  • under the skin (subcutaneously) into fatty tissue in your tummy (abdomen), thigh or upper arm

The injection is called a depot injection. It means that you slowly absorb the drug into your body over a period of time. 

When you have it

You have leuprorelin as an injection once a month or every 3 months.

You must have your injection on time.

Make sure you have your injection on time. If you are more than a few days late, your body might start making testosterone again. 

Tests during treatment

You have blood tests before starting treatment and during your treatment. They check your levels of blood cells and other substances in the blood. They also check how well your liver and kidneys are working.

Side effects

Important information

Other medicines, foods and drink

Cancer drugs can interact with some other medicines and herbal products. Tell your doctor or pharmacist about any medicines you are taking. This includes vitamins, herbal supplements and over the counter remedies.

Treatment for other conditions

Always tell other doctors, nurses, pharmacists or dentists that you’re having this treatment if you need treatment for anything else, including teeth problems.


It is important not to father a child while you are having treatment with this drug and for a few months afterwards. This drug may harm a baby developing in the womb. Talk to your doctor or nurse about effective contraception before starting treatment. 

More information about this treatment

For further information about this treatment go to the electronic Medicines Compendium (eMC) website.

You can report any side effect you have to the Medicines Health and Regulatory Authority (MHRA) as part of their Yellow Card Scheme.

Information and help

Dangoor sponsorship

About Cancer generously supported by Dangoor Education since 2010.