My grandpa (69yo) underwent his surgery for his GIII anaplastic oligodendroglioma back in April, then RT which ended in early July and is now 4 days after his second course of chemo (Temozolomide). While the days when he was taking the chemo were alright, right afterwards he started having heavy nausea and then the next day along with vomiting (despite Ondansetronum anti-vomits) which prevented us from being able to properly hydrate and eat.

So this would be pretty normal but yesterday grandpa became very weak (ie. he was normally walking with a walker through the house just two days before but suddenly you need two people to heavily hold him _and_ a walker for him to be able to walk, and very poorly) and started trembling when trying to do any physical activity like maintaining balance or trying to walk. So i called the ER right away but they told me this was normal after chemo and that those two days of poorer drinking and eating would be enough to trigger it and I should just contact the GP doctor on duty for the weekends in the hospital (a thing in my country) to get another med to stop the vomiting. So I did, we got Metoclopramidum to give alongside the previous meds and the vomiting and nausea became better controlled.

This morning however, grandpa became even weaker, there was no way to sit for him unassisted, no way to stand up, and in order to have him stand you needed three people to hold him cause he wasn't able to help, just straight up like a bag of potatoes. The contact with him was also way poorer - he answered most questions with a "Yes/Mhm/I don't know", and even that was hard to squeeze out of him. So I called ER again, the ambulance came, they tested his blood pressure (stable 120/80), his blood sugar (112, he's diabetic and taking his meds), his reflexes and all the other things they test for and they said that everything was perfectly fine. No sign of dehydration, nothing alarming, no reason to take him to the hospital cause he'd just be there alone and given the same meds we give him at home.

Is that really normal after chemo? Like, as you can see above I spoke to a doctor, I spoke to ER twice on two consecutive days, I spoke to the paramedics in person and everyone told me there was no emergency at hand. At the same time, I'm worried because grandpa flew through the first course of chemo like he was taking mints instead of temozolomide, with no side effects at all, and the second course went smoothly too, but right from the next day after finishing it, it started getting worse - and so far, every day after finishing the second course of chemo was worse than the one that came before it. I just don't know if it's a mix of all his meds with pretty unpleasant side effects (chemo, valproate, dexamethasone, metoclopramidum) that just manifested that way since he wasn't eating and drinking right because of the nausea or something I should be worried about.

Any advice, experiences? Is that really normal? The nausea it pretty much gone now so we're starting to stop the anti-vomit meds, grandpa started to eat a bit more and drink more so we're trying to have him nutritioned and well-hydrated but it just feels so weird to me to see him go from a pretty comfortable way of acting when assisted to straight up not being able to sit on the bed over two days. Is that really normal and I shouldn't be worried? Did you experience things like this, too?