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Prednisolone and cyclosporine

28 Jan 2023 17:23

Hi I was wondering if anyone has any experience taking prednisolone with high dose cyclosporine? My partner had a stem cell transplant last year after a relapse of leukemia. She then relapsed post transplant but had more chemo and is in remission.  She is however suffering gvhd since September and was on 55mg prednisolone per day. This has been reduced to 10mg per day. She also takes high dose cyclosporine.  She was suffering badly with anxiety and her gp prescribed buspirone and diazepam. Her mood has gradually been slipping and I have been her full time carer for 3 years solely on my own. We always had a wonderful relationship right up until this week. She suddenly accused me of being abusive and was acting highly agitated and was petrified of me for no reason. She finally ended the relationship on Wednesday after 6 years, and is refusing to speak with me she wants absolutely nothing to do with me. I'm absolutely devasted.  I've read some effects of each of these drugs which can all cause mood swings etc. But it's so severe I wanted to find out if anyone else has been on these drugs or cared for someone who may have had a similar experience? She hasn't behaved like that with anyone else. I don't want to lose her now after everything. If she passes away from this disease I'll have to lose her all over again and I can't bear it 

Prednisolone and cyclosporine

30 Jan 2023 15:12 in response to Samson08

Hi Samson08,

Welcome to Cancer Chat. I'm sorry to hear of what you are currently going through - this sounds like a really difficult situation.

If others here have similar experience to share, or can offer further support, then hopefully you'll get some more replies soon.

I'm not sure if you have others around you to talk to about this, or perhaps any specialists, but if you'd like to speak to someone then you are welcome to give our nurses a call. You can reach them on 0808 800 4040 (Monday-Friday, 9-5).

I hope that things improve soon and that you are able to reach out to her again.

Wishing you all the best,

Cancer Chat Moderator