I was diagnosed with early stage invasive ductal carcinoma following a routine mammogram earlier this year. I had a lumpectomy with clear margins and clear lymph nodes. I was supposed to have radiotherapy earlier in the Autumn but that all had to be postponed as the major abdominal/urological surgery I had been waiting on was brought forward due to the earlier availability of the surgeons involved. It had originally been planned in to give me some recovery time but that didn't go as hoped. This was due to the benign condition which I've had for almost 20 years resulting in major surgeries, medical retirement, awful pain and a huge disruption to my families lives etc so to be honest the benign condition bit is a joke. Because of that I haven't really given much thought to the cancer and to be honest the diagnosis went straight over my head. It's the treatment and appointments that have been the issue rather than the diagnosis itself. Unfortunately I've been unwell since the major surgery having spent ages in hospital and have had excessive weight loss as I've been nil by mouth for extended periods of time due to bowel obstructions and it's reluctance to function. Had I had my own way I would have opted out of radiotherapy because I feel it's a waste of time with the other stuff I have going on which is too complex for my NHS Trust to deal with and benign or not I feel as if it's killing me. I felt forced into radiotherapy by my family and had I not gone ahead with it had planned to move out my family home into a rented flat because I've struggled to cope with the pressure. I spoke to the radiotherapy nurse about my wish to opt out. She asked an oncologist to speak to me again thinking that I'd be persuaded into the treatment but was basically told I was a bit far out from surgery so it was less likely to be useful, any further delay was a waste of time. I was started on Letrozole which initially was fine. Hot flushes and night sweats but no other side effects. Unfortunately I'm still unwell following surgery and am struggling to see how I can improve this. Some days are better than others but I'm exhausted, can't maintain my weight despite a good dietary intake/supplements etc, I was slim in the first place so too thin now. I saw the specialist gastroenterologist who see's me earlier this week but was so upset afterwards. I have to travel to the other side of the country for the appointment. Basically brain fog, feeling exhausted, problems with speech, recurrent oral thrush and sores in my mouth making eating painful and unpleasant. Everything tastes bitter and metallic, freezing cold all the time often with navy discolouration of my lips and limbs, vaginal bleeding, twitching etc I can't even remember what was said and had to keep apologising because I struggle to finish a sentence and lose my train of thought. She thinks my symptoms are due to iron deficiency which until then hadn't been mentioned although I had been taking over the counter iron off my own back because I knew this would be the case. I'm concerned that Letrozole may be part of the problem as many of the side effects are shared. After speaking with my family we're now in agreement that if I opt out that's fine. I've agreed to persist until December when I have a telephone consultation with an Oncologist. I'm then planning to stop and cancel all further follow ups, mammograms etc because if anything was to be flagged up I won't be willing to have further treatment. In fairness I can't fault the care I've had in relation to the cancer but the other emergency admissions were absolutely dire and downright dangerous. I should say I worked as a Staff Nurse for 30 years prior to ill health retirement. Another reason for opting out is that I still have no access to care, even emergency, in my NHS area for the other issues which has resulted in awful depression. This is despite opting for a less complex type of urostomy in place of what I had previously to allow me to be seen nearer to home. I've made the decision to opt out of all my NHS care and medications apart from gastroenterology at present. I need a GP to prescribe the medication but that's all as I won't be looking for further care from them. Has anyone else experienced side effects from Letrozole after taking it for several months rather than further down the line or made the decision to opt out for similar reasons? Has anyone found low mood a worsened problem when taking it? Thank you.