I took Anagrelide from 1998, as I agreed to be on a trial for it. Unfortunately, in 2000, I gradually became short of breath with swollen feet etc, as I had developed a heart condition and the anagrelide was immediately stopped. Apparently, as a result of the trial, another patient in America also suffered heart damage - my heart was enlarged and the valve did not close properly in the ventricle, allowing blood to bypass it. Three months later I started on hydroxycarbamide with no apparent subsequent side effects and within 2 years, tests showed that my heart had reverted to the 'low end of normal'. Investigating further, I discovered that those on Anagrelide were recomended to be given heart checks before they started and regular checks while taking it. Hopefully, my experience, which was reported, has helped others to take Anagrelide without adverse effects.