Hello SueHu, I had 3 rounds of FEC-T and it knocked me out for months with the fatigue and joint pain you mention. To help - talk to your Cancer Nurse Specialist and/or oncologist or GP to get some pain relief advice, keep exercising, even if only a little each day it is important to keep moving and ideally get some fresh air. When does it wear off? Piece of string - if you are having op or radiotherapy this will likely add to the fatigue. Little naps could help - they helped me. But going for a walk each day helped the most, I think, because it was sociable (I usually went with my mum or any time a friend came round I dragged them out) and I got some fresh air and I could see the seasons changing which gave me a sense of being in contact with nature. That was calming for me. You could also try turmeric tea - some people swear by it, though of course this is not a medical thing and could be a placebo. I am enjoying a lovely turmeric and ginger tea right now, don’t know if it is helping my joint pain but it could be and it is a tasty pick me up! Good luck