DETERMINE is a tumour agnostic trial. Patients with any type of cancer can be recruited onto the trial regardless of where it started in the body. We welcome informal enquiries to discuss your patient’s eligibility and next steps.
The patient must fulfil the eligibility criteria for the trial, as well as any criteria within the specific treatment arm in which they enrol. Experts from across the UK will need to review the patient's clinical and genomic data. Additional tests will then be required to ensure that it's safe for them to take part.
Any adult patient (aged 18 and over) is eligible to join the trial. Children and teenagers may be suitable for some treatments on the trial. This is dependent on evidence from other clinical trials demonstrating it's safe.
The patient must have had a genetic alteration identified within their tumour or circulating tumour DNA. This must be identified prior to joining the trial through the NHS Genomics Medicine Service or an alternative next generation sequencing report.
We welcome informal enquiries to discuss your patient’s eligibility and next steps.
Submit an informal enquiryContact a local investigator at an actively recruiting DETERMINE site to discuss your patient and initiate a referral.
You can also submit an informal enquiry through our form.
After seeking consent from the patient to share their data, the local investigator will make a formal submission to the DETERMINE Molecular Tumour Board.
You'll need to provide any relevant clinical and genomic data.
The Molecular Tumour Board will aim to return their decision to the local investigator within 5 working days.
The patient will need to sign an informed consent document for the specific treatment arm in the trial.
The DETERMINE trial is governed by a master protocol with treatment specific appendices.
DETERMINE (Determining Extended Therapeutic Indications for Existing Drugs in Rare Molecularly Defined Indications Using a National Evaluation Platform Trial)
View NCT05722886 on ClinicalTrials.gov
Arm | Treatment | Actionable mutation | Age range | Clinicaltrials.gov study details |
01 | Alectinib (Alecensa) | ALK positive | Any age | |
02 | Atezolizumab (Tecentriq) | High tumour mutational burden (TMB) or microsatellite instability-high (MSI-high) or proven constitutional mismatch repair deficiency (CMMRD) disposition | Any age | |
03 | Entrectinib (Rozyltrek) | ROS1 gene fusion-positive | Any age | |
04 | Traztuzumab (Herceptin) and Pertuzumab (Perjeta) | HER2 amplification or mutation | Adults and children (12+ years) | |
05 | Vemurafinib (Zelboraf) and Cobimetinib (Cotellic) | BRAF positive | Adults (18+ years) | |
06 | Capmatinib (Tabrecta) | METex14 skipping, MET amplification, MET fusion, or MET activating mutation | Adults (18+ years) |
All treatment arms are currently open.
Trial site | Locationn | Investigator contact | Adult/paediatric site | Status |
Birmingham Women’s and Children’s NHS Foundation Trust | Birmingham | Dr Susanne Gatz | paediatric | in set-up |
University Hospital Birmingham NHS Foundation Trust | Birmingham | Professor Gary Middleton | adult | recruiting |
University Hospitals Bristol and Weston NHS Foundation Trust | Bristol | Dr Antony Ng | adult/paediatric | recruiting |
Cambridge University Hospitals NHS Foundation Trust | Cambridge | Dr Bristi Basu | adult/paediatric | recruiting |
University Hospitals of Leicester NHS Trust | Leicester | Dr Olubukola Ayodele | adult | recruiting |
Alder Hey Children's NHS Foundation Trust | Liverpool | Dr Lisa Howell | paediatric | recruiting |
Clatterbridge Cancer Centre NHS Foundation Trust | Liverpool | Professor Daniel Palmer | adult | recruiting |
Great Ormond Street Hospital | London | Professor Darren Hargrave | paediatric | recruiting |
The Guy's and St Thomas' NHS Foundation Trust | London | Professor James Spicer | adult | recruiting |
University College London Hospitals NHS Foundation Trust | London | Professor Martin Forster | adult | recruiting |
The Christie NHS Foundation Trust | Manchester | Dr Matthew Krebs | adult | recruiting |
The Newcastle upon Tyne Hospitals NHS Foundation Trust | Newcastle upon Tyne | Professor Alastair Greystoke | adult/paediatric | recruiting |
Oxford University Hospitals NHS Foundation Trust | Oxford | Dr Sarah Pratap | adult/paediatric | recruiting |
Sheffield Children's NHS Foundation Trust | Sheffield | Dr Dan Yeomanson | paediatric | recruiting |
Weston Park Hospital | Sheffield | Professor Sarah Danson | adult | recruiting |
University Hospital Southampton NHS Foundation Trust | Southampton | Professor Juliet Gray | adult | recruiting |
The Royal Marsden Hospital NHS Foundation Trust | Surrey | Dr Lynley Marshall | paediatric | recruiting |
Trial site | Location | Investigator contact | Adult/paediatric site | Status |
Velindre University NHS Trust | Cardiff | Professor Robert Jones | adult | recruiting |
Trial site | Location | Investigator contact | Adult/paediatric site | Status |
Western General Hospital (NHS Lothian) | Edinburgh | Dr Stefan Symeonides | adult | recruiting |
Beatson West of Scotland Cancer Centre (NHS Greater Glasgow & Clyde) | Glasgow | Dr Patricia Roxburgh | adult | recruiting |
Royal Hospital For Children, Glasgow (NHS Greater Glasgow & Clyde) | Glasgow | Dr Milind Ronghe | paediatric | recruiting |
Trial site | Location | Investigator contact | Adult/paediatric site | Status |
Belfast Health and Social Care Trust | Belfast | Professor Vicky Coyle | adult | recruiting |
Discover more about DETERMINE through our latest press releases, articles, awards and network updates.
The Cancer Research UK Centre for Drug Development (CDD) partners with academics, biotech, and pharma to deliver early-phase clinical trials.
Explore our information for adult and paediatric patients about the DETERMINE trial.