Determine
A healthcare professional talking to a patient.

DETERMINE for clinicians

About DETERMINE

DETERMINE is a tumour agnostic trial. Patients with any type of cancer can be recruited onto the trial regardless of where it started in the body. We welcome informal enquiries to discuss your patient’s eligibility and next steps.

The patient must fulfil the eligibility criteria for the trial, as well as any criteria within the specific treatment arm in which they enrol. Experts from across the UK will need to review the patient's clinical and genomic data. Additional tests will then be required to ensure that it's safe for them to take part.

Eligibility

  • Any adult patient (aged 18 and over) is eligible to join the trial. Children and teenagers may be suitable for some treatments on the trial. This is dependent on evidence from other clinical trials demonstrating it's safe.

  • The patient must have had a genetic alteration identified within their tumour or circulating tumour DNA. This must be identified prior to joining the trial through the NHS Genomics Medicine Service or an alternative next generation sequencing report.

We welcome informal enquiries to discuss your patient’s eligibility and next steps.

Submit an informal enquiry

What to expect - patient referral

Step 1: Submit an enquiry

Contact a local investigator at an actively recruiting DETERMINE site to discuss your patient and initiate a referral.

You can also submit an informal enquiry through our form.

Step 2: Formal submission

After seeking consent from the patient to share their data, the local investigator will make a formal submission to the DETERMINE Molecular Tumour Board.

You'll need to provide any relevant clinical and genomic data.

Step 3: Decision

The Molecular Tumour Board will aim to return their decision to the local investigator within 5 working days.

The patient will need to sign an informed consent document for the specific treatment arm in the trial.

Study details and treatment arms

The DETERMINE trial is governed by a master protocol with treatment specific appendices.

Master screening protocol

DETERMINE (Determining Extended Therapeutic Indications for Existing Drugs in Rare Molecularly Defined Indications Using a National Evaluation Platform Trial)

View NCT05722886 on ClinicalTrials.gov

Open treatment arms

Arm

Treatment

Actionable mutation

Age range

Clinicaltrials.gov study details

01

Alectinib (Alecensa)

ALK positive

Any age

View NCT05770037

02

Atezolizumab (Tecentriq)

High tumour mutational burden (TMB) or microsatellite instability-high (MSI-high) or proven constitutional mismatch repair deficiency (CMMRD) disposition

Any age

View NCT05770102

03

Entrectinib (Rozyltrek)

ROS1 gene fusion-positive

Any age

View NCT05770544

04

Traztuzumab (Herceptin) and Pertuzumab (Perjeta)

HER2 amplification or mutation

Adults and children (12+ years)

View NCT05786716

05

Vemurafinib (Zelboraf) and Cobimetinib (Cotellic)

BRAF positive

Adults (18+ years)

View NCT05768178

06

Capmatinib (Tabrecta)

METex14 skipping, MET amplification, MET fusion, or MET activating mutation

Adults (18+ years)

View NCT06988475

Closed treatment arms

All treatment arms are currently open.

Participating sites

England

Trial site

Locationn

Investigator contact

Adult/paediatric site

Status

Birmingham Women’s and Children’s NHS Foundation Trust

Birmingham

Dr Susanne Gatz

paediatric

in set-up

University Hospital Birmingham NHS Foundation Trust

Birmingham

Professor Gary Middleton

adult

recruiting

University Hospitals Bristol and Weston NHS Foundation Trust

Bristol

Dr Antony Ng

adult/paediatric

recruiting

Cambridge University Hospitals NHS Foundation Trust

Cambridge

Dr Bristi Basu

adult/paediatric

recruiting

University Hospitals of Leicester NHS Trust

Leicester

Dr Olubukola Ayodele

adult

recruiting

Alder Hey Children's NHS Foundation Trust

Liverpool

Dr Lisa Howell

paediatric

recruiting

Clatterbridge Cancer Centre NHS Foundation Trust

Liverpool

Professor Daniel Palmer

adult

recruiting

Great Ormond Street Hospital

London

Professor Darren Hargrave

paediatric

recruiting

The Guy's and St Thomas' NHS Foundation Trust

London

Professor James Spicer

adult

recruiting

University College London Hospitals NHS Foundation Trust

London

Professor Martin Forster

adult

recruiting

The Christie NHS Foundation Trust

Manchester

Dr Matthew Krebs

adult

recruiting

The Newcastle upon Tyne Hospitals NHS Foundation Trust

Newcastle upon Tyne

Professor Alastair Greystoke

adult/paediatric

recruiting

Oxford University Hospitals NHS Foundation Trust

Oxford

Dr Sarah Pratap

adult/paediatric

recruiting

Sheffield Children's NHS Foundation Trust

Sheffield

Dr Dan Yeomanson

paediatric

recruiting

Weston Park Hospital

Sheffield

Professor Sarah Danson

adult

recruiting

University Hospital Southampton NHS Foundation Trust

Southampton

Professor Juliet Gray

adult

recruiting

The Royal Marsden Hospital NHS Foundation Trust

Surrey

Dr Lynley Marshall

paediatric

recruiting

Wales

Trial site

Location

Investigator contact

Adult/paediatric site

Status

Velindre University NHS Trust

Cardiff

Professor Robert Jones

adult

recruiting

Scotland

Trial site

Location

Investigator contact

Adult/paediatric site

Status

Western General Hospital (NHS Lothian)

Edinburgh

Dr Stefan Symeonides

adult

recruiting

Beatson West of Scotland Cancer Centre (NHS Greater Glasgow & Clyde)

Glasgow

Dr Patricia Roxburgh

adult

recruiting

Royal Hospital For Children, Glasgow (NHS Greater Glasgow & Clyde)

Glasgow

Dr Milind Ronghe

paediatric

recruiting

Northern Ireland

Trial site

Location

Investigator contact

Adult/paediatric site

Status

Belfast Health and Social Care Trust

Belfast

Professor Vicky Coyle

adult

recruiting

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