DETERMINE for clinicians

About DETERMINE

DETERMINE is a tumour agnostic trial. Patients with any type of cancer can be recruited onto the trial regardless of where it started in the body. We welcome informal enquiries to discuss your patient’s eligibility and next steps.

The patient must fulfil the eligibility criteria for the trial, as well as any criteria within the specific treatment arm in which they enrol. Experts from across the UK will need to review the patient's clinical and genomic data. Additional tests will then be required to ensure that it's safe for them to take part.

Eligibility

Any adult patient (aged 18 and over) is eligible to join the trial. Children and teenagers may be suitable for some treatments on the trial. This is dependent on evidence from other clinical trials demonstrating it's safe.
The patient must have had a genetic alteration identified within their tumour or circulating tumour DNA. This must be identified prior to joining the trial through the NHS Genomics Medicine Service or an alternative next generation sequencing report.

We welcome informal enquiries to discuss your patient’s eligibility and next steps.

Submit an informal enquiry

What to expect - patient referral

Step 1: Submit an enquiry

Contact a local investigator at an actively recruiting DETERMINE site to discuss your patient and initiate a referral.

You can also submit an informal enquiry through our form.

Step 2: Formal submission

After seeking consent from the patient to share their data, the local investigator will make a formal submission to the DETERMINE Molecular Tumour Board.

You'll need to provide any relevant clinical and genomic data.

Step 3: Decision

The Molecular Tumour Board will aim to return their decision to the local investigator within 5 working days.

The patient will need to sign an informed consent document for the specific treatment arm in the trial.

Study details and treatment arms

The DETERMINE trial is governed by a master protocol with treatment specific appendices.

Master screening protocol

DETERMINE (Determining Extended Therapeutic Indications for Existing Drugs in Rare Molecularly Defined Indications Using a National Evaluation Platform Trial)

View NCT05722886 on ClinicalTrials.gov

Open treatment arms

Arm	Treatment	Actionable mutation	Age range	Clinicaltrials.gov study details
01	Alectinib (Alecensa)	ALK positive	Any age	View NCT05770037
02	Atezolizumab (Tecentriq)	High tumour mutational burden (TMB) or microsatellite instability-high (MSI-high) or proven constitutional mismatch repair deficiency (CMMRD) disposition	Any age	View NCT05770102
03	Entrectinib (Rozyltrek)	ROS1 gene fusion-positive	Any age	View NCT05770544
04	Traztuzumab (Herceptin) and Pertuzumab (Perjeta)	HER2 amplification or mutation	Adults and children (12+ years)	View NCT05786716
05	Vemurafinib (Zelboraf) and Cobimetinib (Cotellic)	BRAF positive	Adults (18+ years)	View NCT05768178
06	Capmatinib (Tabrecta)	METex14 skipping, MET amplification, MET fusion, or MET activating mutation	Adults (18+ years)	View NCT06988475

Closed treatment arms

All treatment arms are currently open.

Participating sites

England

Trial site	Location	Investigator contact	Adult / paediatric site	Status
Birmingham Women’s and Children’s NHS Foundation Trust	Birmingham	Dr Susanne Gatz	paediatric	in set-up
University Hospital Birmingham NHS Foundation Trust	Birmingham	Professor Gary Middleton	adult	recruiting
University Hospitals Bristol and Weston NHS Foundation Trust	Bristol	Dr Antony Ng	adult / paediatric	recruiting
Cambridge University Hospitals NHS Foundation Trust	Cambridge	Dr Bristi Basu	adult / paediatric	recruiting
University Hospitals of Leicester NHS Trust	Leicester	Dr Olubukola Ayodele	adult	recruiting
Alder Hey Children's NHS Foundation Trust	Liverpool	Dr Lisa Howell	paediatric	recruiting
Clatterbridge Cancer Centre NHS Foundation Trust	Liverpool	Professor Daniel Palmer	adult	recruiting
Great Ormond Street Hospital	London	Professor Darren Hargrave	paediatric	recruiting
The Guy's and St Thomas' NHS Foundation Trust	London	Professor James Spicer	adult	recruiting
University College London Hospitals NHS Foundation Trust	London	Professor Martin Forster	adult	recruiting
The Christie NHS Foundation Trust	Manchester	Dr Matthew Krebs	adult	recruiting
The Newcastle upon Tyne Hospitals NHS Foundation Trust	Newcastle upon Tyne	Professor Alastair Greystoke	adult / paediatric	recruiting
Oxford University Hospitals NHS Foundation Trust	Oxford	Dr Sarah Pratap	adult / paediatric	recruiting
Sheffield Children's NHS Foundation Trust	Sheffield	Dr Dan Yeomanson	paediatric	recruiting
Weston Park Hospital	Sheffield	Professor Sarah Danson	adult	recruiting
University Hospital Southampton NHS Foundation Trust	Southampton	Professor Juliet Gray	adult	recruiting
The Royal Marsden Hospital NHS Foundation Trust	Surrey	Dr Lynley Marshall	paediatric	recruiting

Wales

Trial site	Location	Investigator contact	Adult / paediatric site	Status
Velindre University NHS Trust	Cardiff	Professor Robert Jones	adult	recruiting

Scotland

Trial site	Location	Investigator contact	Adult / paediatric site	Status
Western General Hospital (NHS Lothian)	Edinburgh	Dr Stefan Symeonides	adult	recruiting
Beatson West of Scotland Cancer Centre (NHS Greater Glasgow & Clyde)	Glasgow	Dr Patricia Roxburgh	adult	recruiting
Royal Hospital For Children, Glasgow (NHS Greater Glasgow & Clyde)	Glasgow	Dr Milind Ronghe	paediatric	recruiting

Northern Ireland

Trial site	Location	Investigator contact	Adult / paediatric site	Status
Belfast Health and Social Care Trust	Belfast	Professor Vicky Coyle	adult	recruiting

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DETERMINE for patients

Explore our information for adult and paediatric patients about the DETERMINE trial.