Professor Anne Kiltie

Improving bladder cancer treatment

Professor Anne Kiltie leads the DNA Repair in Cancer Treatment Group at the University of Oxford. She and her team found that bladder cancer cells aren’t very good at repairing their DNA when it becomes damaged, so they’re investigating ways to exploit this weakness.

They’re finding out if drugs that target the DNA repair machinery make the tumour cells more vulnerable to radiotherapy. This could make radiotherapy more powerful and help reduce side effects from having the treatment. 

She is also looking at levels of certain molecules in tumours to see if they could help predict which treatment a person’s bladder cancer is most likely to respond to. Tailoring treatments could help people get the most effective treatment and save more lives. 

On top of this work, Professor Kiltie and her team are testing out an experimental new way to deliver chemotherapy more precisely to bladder tumours, encasing the drugs inside tiny bubbles which can be popped using ultrasound once they reach the tumour. This could reduce damage to healthy cells and hit the tumour directly where it hurts.

Bladder cancer
Cancer biology
Radiotherapy research

CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford