The world's brightest minds

With the generous support of our donors and partners seven remarkable Grand Challenge teams have been funded – each receiving up to £20m to take on some of the toughest challenges in cancer research.

Funded in 2019

Understanding why cancers grow in some tissues and not in others

Professor Elledge's team want to generate a comprehensive map of cancer drivers and their specificity to different tissues. This has the potential to improve our basic understanding of cancer, and provide information that will impact therapeutic choices for patients.

A new way to tackle inflammation-associated cancer

Professor Tlsty's team want to find novel ways of treating cancer that has been caused by inflammation, and develop new options to prevent cancer developing in high-risk patients with chronic inflammatory diseases.

Manipulating the microbiome to beat bowel cancer

Professors Meyerson and Garrett's team want to discover exactly how certain microbes inside the body lead to cancer development and influence a patient’s response to treatment.  

Funded in 2017

Identifying preventable causes of cancer

In a project of epic scale that spans 5 continents, Professor Stratton’s team aim to build a deeper understanding of what causes DNA damage and how it leads to cancer. Their work could help prevent more cancers and reduce the global burden of this disease. 

Creating virtual reality maps of tumours

Combining established techniques with new technology, Professor Hannon’s team will build 3D tumours containing every cell in them, which can be studied using virtual reality. This new way of studying breast cancer could change how the disease is diagnosed, treated and managed.

Preventing unnecessary breast cancer treatment

By studying tissue samples from women with DCIS (a condition which can sometimes develop into breast cancer), Dr Wesseling’s team aims to determine how to distinguish between those who need treatment and those who don’t, which could spare thousands of women unnecessary treatment. 

Studying tumour metabolism from every angle

Using various new mass spectrometry imaging techniques, the team led by Professor Bunch will develop a new way to map tumours in unprecedented detail – from the whole tumour to the individual molecules in cells. The work could lead to new ways to diagnose and treat cancer.

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