Sign up to hear the latest news about Grand Challenge including when we open for year 2.
Challenge 7: Biological Macromolecules
We want to revolutionise cancer treatment so we can kill tumours more effectively than ever before. So-called ‘macromolecules’ are potentially the most powerful drugs we have – but we don’t yet have a good way of getting them into the body.
Therefore our Grand Challenge is to:
DELIVER BIOLOGICALLY ACTIVE MACROMOLECULES TO ANY AND ALL CELLS IN THE BODY TO EFFECTIVELY TREAT CANCER
Read all about this challenge on our science blog
In recent years, scientists have been experimenting with using large molecules called ‘macromolecules’ to target and destroy tumour cells. These macromolecules can disrupt the processes that cancer cells use to survive – for example by stopping them from growing or by flagging their presence to the body’s immune system.
This approach works very well on cancer cells in the laboratory, but unlike conventional ‘small molecule’ treatments like aspirin, it’s really difficult to deliver these molecules to, and then into, the cells where they need to act.
If we could work out ways of delivering these macromolecules to any and every cell in the body, it would not only create a totally new way to treat cancer but would have a huge impact on other diseases too.
Biological macromolecules such as proteins, DNA, RNA, siRNA, and antibodies have already been shown to have huge therapeutic potential in cancer and other diseases. They can be engineered to be far more specific and active than current small-molecule therapies.
The challenge is to deliver these macromolecules to, and into, cells in the body, because their size and properties make it difficult to deliver them into the right cells in an active form.
Existing research mostly focuses on targeting the macromolecule to the tissue of interest. We want to look at an alternative approach: delivering a macromolecular drug to all cells, but ensuring that it is only toxic to cancer cells.
Our Grand Challenge is to make what is true today of small molecule drugs into something that also applies to macromolecules: in other words, to develop a macromolecular drug that can be taken as a pill or similar, such that every cell in the body experiences the drug, but only certain cells are killed.
The focus of this challenge is on delivery mechanisms; designing macromolecules so that they can be taken up by a cell’s normal import mechanisms. This strategy of universal delivery is how the cancer drug Gleevec works – it’s a small molecule drug, in tablet form, and although it does affect normal tissue, its major effect is to kill cells carrying the BCR–ABL fusion protein which is exclusively expressed in tumours.
This is an extraordinarily large challenge, as there are many unresolved components of the delivery problem. These include: establishing the optimal delivery method; crossing endothelial barriers (including the blood–brain barrier); pharmacokinetic issues, and a deepened understanding of cell membrane transport mechanisms.
Progress in any or all of these areas will take us closer to overcoming the most important barrier to efficient drug delivery.
This challenge is almost certain to require interdisciplinary collaborations involving engineering and physical scientists, alongside other disciplines more naturally aligned to drug design and development.
We strongly encourage teams from or including scientists who may have never before thought that their research has relevance to the problem of cancer, drug delivery, or indeed biomedical science, to bring new perspectives and approaches. Teams drawn from a mixture of academic and industry backgrounds would be welcomed.
Given the size of the challenge, teams addressing an important component of the whole problem, for example proposing innovative ways of getting a functionally active macromolecule across one of the biological barriers: endothelial, blood–brain barrier or plasma membrane, would be welcome.
The Grand Challenge Advisory Panel will be looking for truly original approaches, rather than extensions of existing cell targeted methodologies that would not address the challenge of delivering macromolecules to all tissues. Similarly, whilst the nature of the cargo is clearly important and must be taken into account, the real goal of the challenge is the development of new delivery methods, or new macromolecular drugs. Solely in vitro approaches will not be considered unless they hold exceptional promise.
EXPLORE OTHER CHALLENGES
STAY UP TO DATE
Is there a big problem in cancer you think we should address as part of next year's Grand Challenge? Do you have feedback on what we could do better?
We receive no Government funding for our research, so Grand Challenge is only possible thanks to people like you.
If you've been inspired to support our most ambitious funding scheme to date, you can donate today.
Text GRANDC to 70200 to donate £3