
"I am glad that taking part in a trial might help others on their own cancer journey.”
Please note - this trial is no longer recruiting patients. We hope to add results when they are available.
The trial is looking at the drugs vorinostat, bortezomib and dexamethasone for myeloma that has come back.
Doctors can treat myeloma with a drug called bortezomib. You often have bortezomib with a steroid drug called dexamethasone. Adding another drug called vorinostat may improve the treatment. And it may make myeloma less likely to become to bortezomib.
Vorinostat is a type of biological therapy. It is a cancer growth blocker. It stops signals that cancer cells use to divide and grow.
The people taking part in this trial have myeloma that is not responding to treatment or has come back. The aims of the trial are to
You may be able to enter this trial if you
You cannot enter this trial if you
This phase 2 trial will recruit up to 68 people in the UK. Everybody taking part has vorinostat, bortezomib and dexamethasone.
You have 3 week cycles of treatment. You have
You can have bortezomib through a drip into a vein if this is better for you.
You have up to 8 treatment cycles as described above. You then carry on having vorinostat alone. In this part of the trial, you take vorinostat for 4 days every other week. You can carry on having it for as long as it helps you.
You see the trial team and have some tests before you start treatment. The tests include
During the first 8 cycles of treatment, you go to hospital at least 4 times in each 3 week period to have bortezomib injections.
You have regular blood tests, urine tests and bone marrow tests during the trial treatment.
When you finish the treatment, you see the trial team every 2 months until your myeloma starts to get worse.
The most common side effects of vorinostat include
The most common side effects of bortezomib include
The side effects of include
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Dr Faith Davies
Myeloma UK
NIHR Clinical Research Network: Cancer
University of Leeds
Freephone 0808 800 4040
"I am glad that taking part in a trial might help others on their own cancer journey.”