A trial looking at RH-1 for advanced solid tumours

Cancer type:

All cancer types




Phase 1

This trial was looking at a new treatment called RH-1 for advanced solid tumours (not lymphoma or leukaemia). This trial was supported by Cancer Research UK.

Most cancers are treated with standard treatments such as surgery, chemotherapy, radiotherapy, hormone therapy or biological therapy. But sometimes cancer comes back (recur) after treatment. When this happens they can be more difficult to treat because they often don’t respond well to standard treatments.

This trial was looking at a new drug called RH-1. The doctors hoped that RH-1 would be useful in treating cancers that were no longer responding to standard treatments.

RH-1 is called a ‘pro-drug’. This means that it cannot work until it combines with something else in the body. When RH-1 combines with a substance called DTD, it can start to work. DTD is produced in large amounts in some cancer cells.

When the RH-1 reaches cancer cells with a high level of DTD, it starts to work. The doctors hoped that RH-1 would kill these cancer cells.

The aim of this trial was to find the best dose of RH-1 to use. But this was a new and experimental treatment, and we didn’t know yet how well it would work.

Summary of results

The researchers learnt more about RH-1 and the side effects of different doses. But the cancer did not get smaller in any of the people in this trial.

The trial recruited 18 people. Starting with a low dose of RH-1, the researchers gave each person who entered the trial a higher dose. As they didn’t have too many bad side effects, 3 people were given the highest dose. This is called a ‘dose escalation’ study.

At the highest dose, some of the side effects were severe. And so, the researchers found that the dose below was the best dose to give.

The most common side effects that people did have were

After 2 cycles of treatment, the researchers looked at the effect RH-1 had on the cancer. They found that

  • In 7 people, the cancer stayed the same size – researchers call this stable disease Open a glossary item
  • In the other 11 people, the cancer continued to grow

The researchers found the best dose of RH-1 to give that didn’t cause too many bad side effects. And they are now looking at doing more research into RH-1.

We have based this summary on information from the team who ran the trial. As far as we are aware, the information they sent us has not been reviewed independently (peer reviewed Open a glossary item) or published in a medical journal yet. The figures we quote above were provided by the trial team. We have not analysed the data ourselves.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Dr Malcolm Ranson

Supported by

Cancer Research UK (Centre for Drug Development)
Experimental Cancer Medicine Centre (ECMC)
The Christie NHS Foundation Trust

Other information

This is Cancer Research UK trial number CRUKD/03/041.

If you have questions about the trial please contact our cancer information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:

Oracle 223

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Around 1 in 5 people take part in clinical trials

3 phases of trials

Around 1 in 5 people diagnosed with cancer in the UK take part in a clinical trial.

Last reviewed:

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