Last year in the UK over 60,000 cancer patients enrolled on clinical trials aimed at improving cancer treatments and making them available to all.
A trial looking at 17-AAG for advanced melanoma skin cancer (PH2/049)
This trial was looking at a new treatment called 17-AAG for melanoma that had come back after treatment. This trial was supported by Cancer Research UK.
Melanoma is a type of skin cancer. Doctors usually treat it with surgery and sometimes with biological therapy, radiotherapy or chemotherapy. But sometimes the cancer continues to grow despite treatment. 17-AAG is a new drug that doctors think may be useful for melanoma that has continued to grow following treatment.
Many proteins are needed for a cell to grow and divide. 17-AAG blocks several of these proteins. Researchers hoped that blocking these proteins would stop the cancer from growing, or even shrink it a bit. But this was very early research and they were not sure yet how well it would work.
The aims of this trial were to find out
- How well 17-AAG worked for advanced melanoma
- What happened to 17-AAG in the body
- More about the side effects
Summary of results
The researchers were only able to recruit a small number of people into the trial. So they were not able to make any conclusions about how well 17-AAG worked for advanced melanoma or what happened to 17-AAG in the body.
Of the 14 people recruited to this trial, 11 had 17-AAG. And so, the researchers were able to learn more about the side effects of 17-AAG. The main side effects reported were
- Feeling, or being, sick
We have based this summary on information from the team who ran the trial. As far as we are aware, the information they sent us has not been reviewed independently (
How to join a clinical trial
Dr Tim Eisen
Cancer Research UK (Centre for Drug Development)
Experimental Cancer Medicine Centre (ECMC)
Kosan Biosciences Ltd
National Cancer Institute (NCI)
This is Cancer Research UK trial number CRUKD/05/036.